TNF‐α TGF‐β2 and IL‐1β levels in gingival and peri‐implant crevicular fluid before and after de novo plaque accumulation

Schierano, Gianmario; Pejrone, G; Brusco, P; Trombetta, Antonella; Martinasso, Germana; Preti, G; Canuto, Rosa Angela

doi:10.1111/j.1600-051x.2008.01224.x

Cited by 72 publications

(121 citation statements)

References 53 publications

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“…Human experimentally induced peri-implant mucositis studies have elegantly showed that both PICF volume and protein content increases by the end of the 3-week period of plaque accumulation protocol (Salvi et al 2012). Despite the strong clinical similarities among human experimental gingivitis and peri-implant mucositis, the latter is presented with a more pronounced inflammatory response to biofilm accumulation (Salvi et al 2012;Pontoriero et al 1994;Schierano et al 2008). Since the composition of PICF is modified along with the histopathological changes during the course of progressive inflammation, its molecular analysis may support the early detection of clinically undetectable changes.…”

Section: Peri-implant Crevicular Fluid As a Reservoir Of Inflammatorymentioning

confidence: 99%

Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

100

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Biofilms are complex microbial communities that grow on various surfaces in nature. The oral micobiota tend to form polymicrobial biofilms, particularly on the hard mineralized surfaces of teeth, which may impact on oral health and disease. They can cause inflammation of the adjacent tooth-supporting (periodontal) tissues, leading to destructive periodontal disease and tooth loss. The emergence of osseointegrated dental implants as a restorative treatment option for replacing missing teeth has also brought along new artificial surfaces within the oral cavity, on which oral bacteria can form biofilms. As in the case of natural teeth, biofilms on implant surfaces may also trigger infection and cause inflammatory destruction of the peri-implant tissue (i.e. peri-implantitis). While there are strong similarities in the composition of the mixed microbial flora between periodontal and peri-implant infections, there are also a few distinctive differences. The immunological events underlying the pathogenesis of peri-implant infections are qualitatively similar, yet more extensive, compared to periodontal infections, resulting in a faster progression of tissue destruction. This chapter summarizes the current knowledge on the microbiology and immunology of peri-implant infections, including findings from the peri-implant crevicular fluid, the inflammatory exudate of the peri-implant tissue. Moreover, it discusses the diagnosis and current approaches for the treatment of oral infections.

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Section: Peri-implant Crevicular Fluid As a Reservoir Of Inflammatorymentioning

confidence: 99%

Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

100

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“…The majority of the papers regarding oral problems evaluated the content of cytokines in the crevicular fluid [16,18,20], whereas, here the ability of the mucosa cells to synthetize the cytokines involved in the inflammatory process and the factors involved in the osteogenesis has been evaluated.…”

Section: Discussionmentioning

confidence: 99%

“…Among inflammatory factors, inteurleukin-1β (IL-1β), IL-6 and prostaglandin-E2 (PGE2) are factors present in the gingival crevicular fluid involved in the establishment of inflammatory processes in the oral cavity [18,19], whereas IL-10 and transforming growth factor (TGF)-β2 can be involved in the healing processes.…”

Section: Introductionmentioning

confidence: 99%

Superpulsed laser therapy on healing process after tooth extraction in patients waiting for liver transplantation

et al. 2011

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Alveolar healing following tooth extraction is a complex repair process involving different tissues, including epithelium and bone.This research aimed to study the effect of laser therapy on alveolar healing process in patients waiting for liver transplantation, evaluating some inflammation, osteogenesis and clinical parameters.Twelve patients with hepatic failure waiting for liver transplantation, with indications to bilateral extraction, entered the split-mouth study. One post-extractive defect was treated with laser while the other was left without treatment. Specimens of soft tissues were removed from around the tooth before extraction and after 7 days.Superpulsed laser irradiation prevented IL-1β increase and induced IL-6, IL-10 and collagen III increase at 7 days in comparison with their level before extraction, whereas the other parameters were unmodified. Moreover, the epithelial regeneration evidenced a positive result of laser therapy, and the patients reported a lower pain in the site treated with laser.In conclusions, laser therapy appears to be a treatment of choice for patients, providing clinical efficacy, being safe, well tolerated and able to prevent inflammation.

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“…17 The increase in TNF-α levels in peri-implant crevicular fluid (PICF) is reported to cause peri-implantitis. 10 To our knowledge, there are no published studies in which TNF-α levels around miniscrew implants were measured. Therefore, the goal of this study was to measure TNF-α levels around miniscrews during a 3-month period of canine distalization and to compare the results with the cytokine levels around healthy teeth.…”

Section: Introductionmentioning

confidence: 99%

“…Cytokines such as TNF-α have an important role in regulating and amplifying the inflammatory response in periodontal and peri-implant tissues. [8][9][10] Implant anchorage was recently established as an effective treatment for a wide variety of adult malocclusions. 11 Dental implants, miniplates, and titanium ); T2, T3, T4, T5, T6, and T7 mean 1 hour, 1 day, 2 days, 1 week, 3 weeks, and 3 months after activation, respectively; SD, standard diviation.…”

Section: Introductionmentioning

confidence: 99%

Identification of tumor necrosis factor-α levels around miniscrews during canine distalization

et al. 2011

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Objective: The aim of this study was to measure tumor necrosis factor-α (TNF-α) levels around miniscrews used for anchorage during a 3-month period of canine distalization. Methods: Sixteen patients (8 boys, 8 girls; mean age, 16.6 ± 2.4 years) whose upper first premolars were extracted for orthodontic treatment were included in this study. Miniscrews were used as an anchorage unit in canine distalization. Thirty-two (32) miniscrew implants were placed bilaterally in the alveolar bone between the maxillary second premolars and first molars. The treatment, miniscrew, and control groups comprised upper canines, miniscrew implants, and upper first premolars, respectively. Peri-miniscrew implant crevicular fluid and gingival crevicular fluid were obtained before applying force and at 1, 24, and 48 hours, and at 7 and 21 days, and 3 months after applying force. Results: During the 3-month period, the TNF-α levels increased significantly at 24 hours only in the treatment group (p ＜ 0.01). In the miniscrew and control groups, there were no statistically significant changes. No significant differences were observed between groups. Conclusions: Miniscrews can be conveniently used for anchorage in orthodontics.

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TNF‐α TGF‐β2 and IL‐1β levels in gingival and peri‐implant crevicular fluid before and after de novo plaque accumulation

Abstract: These data suggest that increased volumes of GCF and PICF could be useful markers of early inflammation in gingival and peri-implant tissues. In the presence of de novo plaque, implants showed lower, and nearly significant, levels of IL-1beta compared with teeth.

Cited by 72 publications

References 53 publications

Peri-Implant Infections of Oral Biofilm Etiology

Peri-Implant Infections of Oral Biofilm Etiology

Superpulsed laser therapy on healing process after tooth extraction in patients waiting for liver transplantation

Identification of tumor necrosis factor-α levels around miniscrews during canine distalization

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