TNF-alpha polymorphisms and breast cancer

Abstract

Tumor necrosis factor-α (TNF-α) is an important pro-inflammatory cytokine in the development and progress in human cancer. TNF-α polymorphisms have been confirmed to influence the risk for several types of cancer, however, the associations between TNF-α polymorphisms and breast cancer (BC) remain controversial and ambiguous. The aim of this meta-analysis is to explore more precise estimations regarding this point. Electronic searches of several databases were conducted for all online publications on the associations between TNF-α-238, -308, -857, -863, -1031, -1210 polymorphisms and BC through March 2011. Odds ratios (OR) with 95% confidence intervals (95% CI) were calculated to assess the strength of these associations in fixed- and random-effect models with Review manager 5.0. A total of 17 studies with 44,442 BC patients and 49,926 controls involved were identified. This meta-analysis showed no significant association between TNF-α-308 polymorphism and BC (AA + GA vs. GG: OR = 0.95, 95% CI = 0.82-1.09) in overall and (OR = 1.44, 95% CI = 0.61-3.40) Asian populations, however, a negative association was shown in Caucasian subgroup (OR = 0.91, 95% CI = 0.85-0.97). As regards the TNF-α-238 polymorphism, the OR values (95% CI) were 0.99 (0.94-1.05), 0.94 (0.78-1.14), and 1.00 (0.95-1.05) for the overall, Asian, and Caucasian studies, respectively. No significant associations were found for other polymorphisms. Furthermore, there was a coincidence in the sensitivity analysis of these associations. No publication bias was detected in this study. To sum up, no significant associations were found between the TNF-α-308, -238, -857, -863, -1031, -1210 polymorphisms and the risk for BC in overall populations, whereas a negative association was found between TNF-α-308 polymorphism and BC in Caucasian populations.

Association of tumor necrosis factor-α gene polymorphism with osteoarticular tuberculosis prognosis in a Hebei population

“…There have been many reports on the association of TNF-α-308, -238, and -863 with different diseases, such as hepatitis B virus infection (Du et al, 2006;Basturk et al, 2008) and breast cancer (Yang et al, 2011). In our study, we combined the three SNPs and the haplotype association analysis of TNF-α SNPs (-308/-238/-863) showed that the TNF-α AGA haplotype was present at a higher frequency in the OA-TB patients (12.1%) than in the healthy volunteers (3.5%), indicating that it was a risk factor for OA-TB (OR = 4.201, 95%CI = 1.80-9.91, P = 0.010).…”

Association of the tumor necrosis factor-alpha -308G>A polymorphism with breast cancer in Mexican women

“…In the Mexican population, studies have reported a frequency of 0-8% of the mutant allele (Parra et al, 2006;Sánchez et al, 2008). Although this polymor-phism has been associated with diseases such as rheumatism (Cereda et al, 2012), cardiovascular disease (Chu et al, 2012), diabetes , and cancer (Yang et al, 2011), the results have been inconsistent. The aim of this study was to determine the association between the -308G>A polymorphism in the TNF-α gene and BC in Mexican women.…”

The -308G/A Polymorphism of the Tumor Necrosis Factor-alpha Gene Is Associated with the Risk of Upper Aerodigestive Tract Cancer: A Meta-analysis

“…The TNF-α gene is located within the MHC region on chromosome 6p21.3 (Noguchi et al 2002). Several single-nucleotide polymorphisms have been identified in this region, and the -308G/A polymorphism of the TNF-α gene is the most frequently studied one (Guo et al 2005;Whiteman et al 2010;Yang et al 2011b). It has been illustrated that the G to A nucleotide change at -308 alters the transcription factor binding site, resulting in increased production of TNF-α (Abraham and Kroeger 1999;Elahi et al 2009).…”