TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus

Rood, M. J.; Krugten, M V van; Zanelli, Eric; Linden, M.W. van der; Keijsers, V.; Schreuder, G. M. T.; Verduyn, W.; Westendorp, R. G. J.; Vries, R. R. P. De; Breedveld, F C; Verweij, C. L.; Huizinga, Tom W J

doi:10.1002/1529-0131(200001)43:1<129::aid-anr16>3.0.co;2-s

Cited by 167 publications

(114 citation statements)

References 26 publications

(20 reference statements)

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“…The AA genotype in the TNF-α -308 G>A polymorphism has been significantly associated with increased production of TNF-α and, in some cases, with increased morbidity and mortality in sepsis, malaria, chronic obstructive pulmonary disease, leishmaniasis, systemic lupus erythematosus, autoimmune type 1 hepatitis, and other diseases mediated by the immune system (32). This allele also seems to be involved in the development of inflammatory and degenerative diseases, like rheumatoid arthritis (33), systemic lupus erythematosus (34), and rheumatic fever (35).…”

Section: Discussionmentioning

confidence: 99%

Association Between Apical Periodontitis and TNF-α -308 G>A Gene Polymorphism: A Systematic Review and Meta-Analysis

et al. 2017

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Currently, investigations have focused on the identification of Single Nucleotide Polymorphisms (SNP) involved in host response and its ability to generate an immunity deficiency. The aim of this study was to perform a systematic review (SR) and metaanalysis to evaluate the association between TNF-α -308 G>A polymorphism and apical periodontitis (AP) phenotypes. A broad search for studies was conducted. The following databases were used: PubMed, Scopus, Web of Science, and VHL (Medline, SciELO, Ibecs, and Lilacs). The MeSH terms "Periapical Periodontitis," "Periapical Abscess," "Polymorphism, Genetic," and "Polymorphism, Single Nucleotide" were used. MeSH synonyms, related terms, and free terms were included. Clinical investigations of individuals with different AP phenotypes in permanent teeth were selected. After application of the eligibility criteria, selected studies were qualified by assessing their methodological quality. A fixed effect model was used for the meta-analysis. The initial search identified 71 references. After excluding duplicate abstracts, 33 were selected. From these, two were eligible for quality assessment and were classified as being of moderate evidence. The included studies did not demonstrate association between AP and TNF-α -308 G>A SNP. However, the meta-analysis demonstrated an association between the genotype distribution and AP phenotype (OR= 0.49; confidence interval= 0.25, 0.96; p=0.04). The role of TNF-α -308 G>A SNP in AP phenotypes is debatable. Further studies are needed to confirm and understand the underlying mechanisms of the identified association.

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Section: Discussionmentioning

confidence: 99%

Association Between Apical Periodontitis and TNF-α -308 G>A Gene Polymorphism: A Systematic Review and Meta-Analysis

et al. 2017

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“…Fifteen patients and 7 controls who were positive for DRB1*03 were negative for the TNF2 allele, and 13 patients and 4 controls who were positive for the TNF2 allele were negative for DRB1*03. The conflicting results concerning the independence of TNF2 and HLA-DR in the genetic predisposition to systemic lupus erythematosus (32,33) shows how difficult it is to evaluate the importance of linkage disequilibrium in the interaction of these 2 factors in susceptibility to human diseases.…”

Section: Discussionmentioning

confidence: 99%

Association of transforming growth factor β1 and tumor necrosis factor α polymorphisms with anti‐SSB/La antibody secretion in patients with primary Sjögren's syndrome

Gottenberg¹,

Busson²,

Loiseau³

et al. 2004

Arthritis & Rheumatism

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Objective. To determine whether cytokine gene polymorphisms of interferon-␥ (IFN␥), interleukin-6 (IL-6), IL-10, tumor necrosis factor ␣ (TNF␣), and transforming growth factor ␤1 (TGF␤1) predispose subjects to the development of primary Sjögren's syndrome (SS).Methods. Single-base-exchange cytokine gene polymorphisms were analyzed in 129 French patients with primary SS who fulfilled the American-European Consensus Group criteria, as well as in 96 unrelated healthy subjects.Results. The frequency of the TNF-308A (TNF2) allele was significantly higher in the SS patients (26% versus 11%). This TNF2 association was restricted to patients with anti-SSB (37% versus 11% in controls). Stratification did not reveal an independent effect of TNF2 and HLA-DRB1*03 on disease or on anti-SSB antibody secretion. The frequency of allele C at codon 10 of TGF␤1 was strongly increased in the subgroup of patients with anti-SSB; this allele acted synergistically with DRB1*03 to predispose patients to the secretion of anti-SSB. The IL-10 GCC haplotype carrier rate was significantly higher in SS patients than in controls (67% versus 48%), but the IL-10 allele and genotype frequencies were not significantly different. No association was found between IL-6 or IFN␥ polymorphisms and primary SS.Conclusion. TNF2 was associated with anti-SSB antibody secretion, although this association was not independent of the association with DRB1*03. Allele C at codon 10 of TGF␤1 was found to act synergistically with DRB1*03 in predisposing patients to the secretion of anti-SSB. These results therefore suggest that most of the known genetic predisposition to primary SS might concern the pattern of autoantibody diversification.

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“…El alelo TNF2 se ha asociado con susceptibilidad al LES en poblaciones caucásicas, tanto en desequilibrio de ligamiento con HLA-DR3 (45,46) como independientemente de este locus (47,48). Por el contrario, en población mexicana con alto porcentaje amerindio (49) o en africanos (46) no se ha observado tal asociación.…”

Section: Discussionunclassified

Polimorfismo del TNF-alpha en autoinmunidad y tuberculosis.

Correa¹,

Gómez²,

Anaya³

2004

biomedica

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TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus

Cited by 167 publications

References 26 publications

Association Between Apical Periodontitis and TNF-α -308 G>A Gene Polymorphism: A Systematic Review and Meta-Analysis

Association Between Apical Periodontitis and TNF-α -308 G>A Gene Polymorphism: A Systematic Review and Meta-Analysis

Association of transforming growth factor β1 and tumor necrosis factor α polymorphisms with anti‐SSB/La antibody secretion in patients with primary Sjögren's syndrome

Polimorfismo del TNF-alpha en autoinmunidad y tuberculosis.

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