2012
DOI: 10.1016/j.jss.2010.12.005
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TLR4 Mediates Lung Injury and Inflammation in Intestinal Ischemia-Reperfusion

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Cited by 88 publications
(67 citation statements)
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“…31 The lung is frequently damaged by proinflammatory mediators released from the injured liver after liver IR, as the lungs are the first capillary bed that is reached by the blood after leaving the hepatic circulation. [3][4][5][6][7] was recently found to act as a potent proinflammatory cytokine and participated in the development of systemic inflammatory response, when it was released into the extracellular environment.…”
Section: Discussionmentioning
confidence: 99%
“…31 The lung is frequently damaged by proinflammatory mediators released from the injured liver after liver IR, as the lungs are the first capillary bed that is reached by the blood after leaving the hepatic circulation. [3][4][5][6][7] was recently found to act as a potent proinflammatory cytokine and participated in the development of systemic inflammatory response, when it was released into the extracellular environment.…”
Section: Discussionmentioning
confidence: 99%
“…For example, Toll-like receptor (TLR)4 was shown to contribute to the regulation of vascular permeability [23][24][25][26][27]. Therefore, the development of the synthetic TLR4 antagonist eritoran to suppress TLR4/MD2-mediated signalling was highly promising.…”
Section: Corticosteroidsmentioning
confidence: 99%
“…TLR4 recognises pathogen-associated proteins, such as LPS, and activates the nuclear factor Îș-light-chain-enhancer of activated B cells (NF-ÎșB) signalling pathway, leading to the secretion of inflammatory cytokines and chemokines (9). In chronic diseases, NF-ÎșB is known to be activated; this efficiently initiates and accelerates the inflammatory response and induces the immune response (10)(11)(12). Although it is well established that TLR4 affects downstream NF-ÎșB activation, the effect of triptolide on TLR4-NF-ÎșB signalling has yet to be elucidated.…”
Section: Introductionmentioning
confidence: 99%