TLR4 D299G Polymorphism Modulates Cytokine Expression in Ulcerative Colitis

Meena, Naresh Kumar; Verma, Ravi; Verma, Nirmal; Ahuja, Vineet; Paul, Jaishree

doi:10.1097/mcg.0b013e31828a6e93

Cited by 31 publications

(22 citation statements)

References 33 publications

(30 reference statements)

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“…The results were predominantly consistent with previous studies [27, 32], which reported that the TLR4 T399I polymorphism may be significantly linked to the incidence and development of CD, demonstrating that the TLR4 T399I polymorphism may be used as a biomarker for the early diagnosis of CD. This result was very well supported: sensitivity analysis excluding any studies did not significantly change the magnitude of the genetic model and/or gene effect.…”

Section: Discussionsupporting

confidence: 82%

Association between Toll-Like Receptor 4 T399I Gene Polymorphism and the Susceptibility to Crohn’s Disease: A Meta-Analysis of Case-Control Studies

Shen

Lei

et al. 2018

Digestion

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Background/Aims: This article was undertaken to investigate the association of toll-like receptor 4 (TLR4) polymorphism (Thr399Ile) and risk of Crohn’s disease (CD) by performing a meta-analysis. Methods: Articles were chosen based on PubMed, Embase, China National Knowledge Internet, and Chinese Wanfang databases (up to 12th October 2016). Specific inclusion criteria were used to evaluate articles. Meta-analysis was performed by using a random or fixed effect model. Fifteen eligible case-control studies were finally included into this meta-analysis. We estimated the summary OR with its corresponding 95% CI to assess the association. Results: Summary results of this meta-analysis showed a moderate association between the TLR4 T399I polymorphism and the risk of CD (allele model: OR 1.26, 95% CI 1.06–1.50, p = 0.009; heterozygote model: OR 1.36, 95% CI 1.11–1.66, p = 0.003; dominant model: OR 1.35, 95% CI 1.10–1.64, p = 0.004; homozygote model: OR 1.08, 95% CI 0.44–2.64, p = 0.866; recessive model: OR 0.97, 95% CI 0.40–2.35, p = 0.946). Stratified analysis on geographical area, ethnicity, and genotypic methods suggested that the polymorphism was associated with increased risk of CD in Asia and Asians, and “T” allele only moderately increased CD risk within polymerase chain reaction-restricted fragment length polymorphism. Conclusions: Our meta-analysis suggests that TLR4 T399I polymorphism is moderately associated with susceptibility to CD, and more studies are needed to confirm our conclusion.

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Section: Discussionsupporting

confidence: 82%

Association between Toll-Like Receptor 4 T399I Gene Polymorphism and the Susceptibility to Crohn’s Disease: A Meta-Analysis of Case-Control Studies

Shen

Lei

et al. 2018

Digestion

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“…described an association between rs5743704 gene polymorphisms of TLR2 and lower prevalence of antibodies against the outer membrane porin, which is the component of the outer membrane of gram‐negative bacteria, in patients with IBD . Polymorphisms in the TLR2 and TLR4 gene were significantly associated with IBD in several cohorts and may contribute to modulating transcription of inflammatory cytokines leading to aberrant immune responses . Recently, increased colonic expression of TLR2 and TLR4, accompanied by enhanced production of mucosal pro‐inflammatory cytokines, was observed in patients with mixed or alternating bowel habits (A‐IBS) …”

Section: Discussionmentioning

confidence: 99%

Increased serum levels of lipopolysaccharide and antiflagellin antibodies in patients with diarrhea‐predominant irritable bowel syndrome

Dlugosz

Nowak

D’Amato

et al. 2015

Neurogastroenterology Motil

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“…In another study from our centre, we reported the association of the TLR4 D299G polymorphism with both UC and CD, and of the T399I polymorphisms only in UC [45] . These polymorphisms contribute to modulating the transcription of inflammatory cytokines in UC, leading to an aberrant immune response.…”

Section: +mentioning

confidence: 99%

Epidemiology of Inflammatory Bowel Disease in India: The Great Shift East

2017

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TLR4 D299G Polymorphism Modulates Cytokine Expression in Ulcerative Colitis

Abstract: Polymorphisms in TLR4 gene were significantly associated with inflammatory bowel disease in North Indian population and they contribute in modulating transcription of inflammatory cytokines during UC leading to aberrant immune response.

Cited by 31 publications

References 33 publications

Association between Toll-Like Receptor 4 T399I Gene Polymorphism and the Susceptibility to Crohn’s Disease: A Meta-Analysis of Case-Control Studies

Association between Toll-Like Receptor 4 T399I Gene Polymorphism and the Susceptibility to Crohn’s Disease: A Meta-Analysis of Case-Control Studies

Increased serum levels of lipopolysaccharide and antiflagellin antibodies in patients with diarrhea‐predominant irritable bowel syndrome

Epidemiology of Inflammatory Bowel Disease in India: The Great Shift East

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