Titanium dioxide nanotubes enhance bone bonding <i>in vivo</i>

Bjursten, Lars Magnus; Rasmusson, Lars; Oh, Seunghan; Smith, Gudmund J. W.; Brammer, Karla S.; Jin, Sung‐Ho

doi:10.1002/jbm.a.32463

Cited by 336 publications

(266 citation statements)

References 20 publications

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“…Investigators are refining dental implants by the addition of nano tubes to the outward of the implant. It increases the capability to load the nanotubes with antiinflammatory drugs that can be applied directly to the area around the implant [39]. Silver nanoparticles have gained an ever increasing attention in orthopaedics due to their promising antimicrobial features.…”

Section: Orthodontology and Orthopedicsmentioning

confidence: 99%

“…Number of studies have been reported in past few years related to the efficacy and safety of various nanoparticles like cholesteroltethered platinum II-based supramolecular nanoparticle [37][38][39][40][41], polymeric-ceramic nanocarriers (NCs) in order to achieve oral delivery of the anticancer neutraceutical iron-saturated bovine lactoferrin (Fe-bLf) protein) [42,43], novel alginate-enclosed chitosan-calcium phosphate-loaded iron-saturated bovine lactoferrin nanocarriers for oral delivery in colon cancer therapy etc. [44][45][46][47][48][49][50].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Scope of Nanotechnology in Drug Delivery

Maroof¹,

Zafar²,

Ali³

et al. 2015

J Bioequiv Availab

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Section: Orthodontology and Orthopedicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Scope of Nanotechnology in Drug Delivery

Maroof¹,

Zafar²,

Ali³

et al. 2015

J Bioequiv Availab

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“…Researches demonstrate that the nanotubes accelerate osteoblast adhesion and growth [5] , enhance apatite deposition [6], exhibit excellent bioactivity [7], improve bone bonding in vivo [8], demonstrate better corrosion resistance [9] and can be a drug delivery vehicle [10]. TiO 2 nanotube layer can be produced by many methods, including template-assisted methods , sol-gel techniques, and hydro/solvothermal methods (with or without templates) [11].…”

Section: Introductionmentioning

confidence: 99%

Elastic modulus evaluation of Titania nanotubes obtained by anodic oxidation

et al. 2014

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The use of titania (TiO 2 ) nanotubes is becoming one of the most attractive techniques as surface treatment for implants due its combination of morphology (that accelerates osteoblast adhesion and proliferation), bioactivity and possibility of being use as a drug vehicle. Anodic oxidation is one of the cheapest and simplest approaches to obtain highly ordered nanotubes. Parameters such as applied potential, reaction time and fluoride containing in the electrolyte define the nanotubes morphology. However, the mechanical properties of the nanotubes layer do not have been completely elucidated and they play a crucial role in the implant long term stability. The objective of this research was to obtain TiO 2 nanotubes using anodic oxidation and to determine their elastic modulus and hardness. The TiO 2 nanotubes layer was obtained in a fluoride containing electrolyte for 1 hour, one group at 15 V and another one at 25 V. The TiO 2 nanotubes morphology was characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The elastic modulus and hardness were evaluated by nanoindentation experiments using a spherical tip. SEM images showed highly ordered nanotubes on all titanium surfaces and it was observed that the nanotubes diameters are directly related with the applied potential. Nanotubes diameters are 66 ± 9 nm and 131 ± 22 nm for nanotubes obtained at 15 V and 25 V, respectively. Nanoindentation test results showed a decrease in the elastic modulus comparing with titanium reference and these values approach to cortical bone elastic modulus. These results demonstrate that it was possible to obtain a homogeneous TiO 2 nanotubes layer that has mechanical properties adequate to improve implant long-term stability.

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“…5 Recently, it has been reported that surfaces with nano features, either disordered 6,7 or ordered (e.g. gold nanoparticle arrays, 8 titanium nanotube arrays, [9][10][11][12] chemically etched titanium surfaces, 13,14 and nanostructured tantalum surfaces) [15][16][17] can greatly improve cell adhesion, proliferation and differentiation. 18 Our group has developed a general nano-patterning method for metal surfaces that is inexpensive as well as time-efficient.…”

Section: Introductionmentioning

confidence: 99%

Ordered nano-scale dimple pattern formation on a titanium alloy (Ti-6Al-4V)

2012

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Due to the many applications of nanostructured surfaces – including in biomaterials – there is a strong interest in cost- and time-efficient methods for their fabrication. Previously, our group established a simple electrochemical method generating nanoscale patterns on large areas of a number of different metal surfaces. They consist of dimples that are around 6-10 nm deep and hexagonally closed packed with a tunable periodicity of around 50 nm. Ordering requires careful tuning of the surface chemistry, which makes the translation of these findings to multi-component alloys non-obvious. Here, we demonstrate for the first time that such a pattern can also be achieved on the surface of an alloy, namely Ti-6Al-4V. This alloy is of particular interest for biomedical implants. While dimple formation on the main component metals titanium and aluminum has previously been reported (albeit under conditions that differ from each other), we now also report dimple formation on pure vanadium surfaces to occur under very different conditions. Dimple formation occurs preferentially on the (dominant) α-phase grains of the alloy. The size of dimples of the alloy material is subject to the electropolishing potential, electrolyte concentration and surface chemical composition, which gives us the opportunity to control the surface features. Since a main application of this alloy are biomedical implants, this level of control will be an important tool for accommodating cell growth

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Titanium dioxide nanotubes enhance bone bonding in vivo

Cited by 336 publications

References 20 publications

Scope of Nanotechnology in Drug Delivery

Scope of Nanotechnology in Drug Delivery

Elastic modulus evaluation of Titania nanotubes obtained by anodic oxidation

Ordered nano-scale dimple pattern formation on a titanium alloy (Ti-6Al-4V)

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