Tissue transglutaminase is essential for neurite outgrowth in human neuroblastoma SH-SY5Y cells

An Autocrine Loop Involving Ret and Glial Cell–Derived Neurotrophic Factor Mediates Retinoic Acid–Induced Neuroblastoma Cell Differentiation

“…Thus, we asked whether RA induces tissue transglutaminase expression via a Ret-independent mechanism or whether RA requires Ret activity to regulate tissue transglutaminase levels. Consistent with previous reports (27), RA induces rapid accumulation of tissue transglutaminase (Fig. 3L, top).…”

“…Indeed, both the expression and the activity of tissue transglutaminase are strongly enhanced by RA and have been shown to be necessary for RA-induced cell differentiation and ERK activation in neuroblastoma cell lines (26)(27)(28). Thus, we asked whether RA induces tissue transglutaminase expression via a Ret-independent mechanism or whether RA requires Ret activity to regulate tissue transglutaminase levels.…”

Role of transglutaminase 2 in PAC1 receptor mediated protection against hypoxia-induced cell death and neurite outgrowth in differentiating N2a neuroblastoma cells

“…Previous studies have shown that TG2 is essential for differentiation/neurite outgrowth in human neuroblastoma SHSY5Y cells (Tucholski et al, 2001;Singh et al, 2003).…”

“…Previous studies have shown that TG2 protects human SH-SY5Y neuroblastoma cells against heat shock-induced cell death (Tucholski et al, 2001). Similarly, TG2 mediates protection of neuronal cells against hypoxia and oxygen/glucose deprivation-induced cell death by attenuating the HIF hypoxic response pathway (Filiano et al 2008).…”

“…In neuronal cells, TG2 is involved in neural differentiation, neurite outgrowth and neuroprotection following cerebral ischaemia (Tucholski et al, 2001;Filiano et al, 2010;Vanella et al, 2015).…”