Tissue Specificity of Premature Aging in Diabetes Mellitus The Role of Cellular Replicative Capacity

Mooradian, Arshag D.

doi:10.1111/j.1532-5415.1988.tb04269.x

Cited by 28 publications

(12 citation statements)

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“…The increased oxidative stress may contribute to the pathogenesis of the diabetic complications, notably the emergence of premature atherosclerosis [4][5][6]. In addition, increased oxidative injury has been implicated in the premature age-related changes in diabetes [7]. Thus, older diabetic subjects are probably at higher risk of oxidative injury [8].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant vitamins and their influence in diabetes mellitus

Hasanain

Mooradian

2002

Curr Diab Rep

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Diabetes mellitus is a chronic disease associated with serious complications. A number of studies have suggested that enhanced oxidation is the underlying abnormality responsible for some of the complications of diabetes. It is not known whether the ingestion of antioxidant vitamins could retard or perhaps reverse the oxidative damage. The information regarding the benefit of antioxidant vitamin supplementation is conflicting some trials have demonstrated adverse effects of excessive consumption of vitamin supplements. In this article, we review the available literature on the association of cardiovascular events and ingestion of vitamins with antioxidant properties. Given the lack of data to substantiate the benefit and safety of ingestion of antioxidant vitamins in excess of the recommended dietary allowance, physicians should avoid the recommendation of vitamin supplementation to their patients.

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Section: Introductionmentioning

confidence: 99%

Antioxidant vitamins and their influence in diabetes mellitus

Hasanain

Mooradian

2002

Curr Diab Rep

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“…Type 2 diabetes mellitus (T2DM) is a state of accelerated aging (1, 2). It is well recognized that T2DM prematurely hastens cardiovascular, renal and ocular decline (3).…”

Section: Introductionmentioning

confidence: 99%

Diabetic serum from older women increases adipogenic differentiation in mesenchymal stem cells

2018

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Background: Paradoxically, elderly persons with type 2 diabetes mellitus (T2DM) fracture despite having higher bone density than nondiabetics. Systemic factors associated with aging and T2DM may have detrimental, local effects on the skeleton. One such factor could be by altering the microenvironment of the mesenchymal stem-cells (MSCs), multipotent progenitors capable of differentiating into adipocytes or osteoblasts. Methods Sera were obtained from four participant groups (n=40 total, 10 per group): 1) young women with normal glucose tolerance (NGTY), 2) post-menopausal women with NGT) 3) post-menopausal women with impaired glucose tolerance (IGT) and 4) post-menopausal women with T2DM. Sera were incubated with human MSCs for 14 days. Cell proliferation and apoptosis were measured using EdU and TUNEL labeling assays, respectively. MSC differentiation for each group were determined using osteogenic and adipogenic gene expression markers quantified by qRT-PCR, as well as Alizarin Red and Oil Red O staining. Results: Expression of adipogenic genes was greater than 2 fold higher (P<0.05) in MSCs cultured with T2DM sera compared to those incubated with NGTY, NGT or IGT sera. The increase in adipogenic gene expression corresponded with increased Oil Red O staining. Despite the increased adipogenic differentiation of MSCs exposed to T2DM sera, cell proliferation and apoptosis rates as well as osteoblastic activity were not significantly different amongst the four conditions. Conclusions: Systemic, circulating factors in the serum of older women with T2DM may promote MSC differentiation into adipocytes versus osteoblasts. Increased differentiation of MSCs into adipocytes is one possible mechanism by which T2DM increases fracture risk.

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“…These include impairment of cognitive performance, decreased blood-brain barrier transport of glucose and choline, increases in collagen cross-links in skin, dura and tendon and increased capillary basement membrane thickening [37]. Abnormalities of oxidative stress have been increasingly recognized in this metabolic disorder and include both increased plasma lipid peroxidation and reduced antioxidant protection, particularly ascorbate [38], providing additional but indirect support for free radicals playing a role in the morphological changes accompanying ageing.…”

Section: Biochemical and Cellular Characteristicsmentioning

confidence: 99%