Tissue residue depletion kinetics and withdrawal time estimation of doxycycline in grass carp, Ctenopharyngodon idella, following multiple oral administrations

Xu, Ning; Li, Miao; Fu, Yujian; Zhang, Xiaomei; Ai, Xiaohui; Lin, Zhoumeng

doi:10.1016/j.fct.2019.110592

Cited by 23 publications

(27 citation statements)

References 59 publications

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“…We found that DC concentrations were the highest in relevant tissues and plasma at the initial time after multiple oral doses; DC concentrations in the liver were the highest compared to the same time stage in other tissues (except the first sampling time) and presented the slowest depletion, up to 35 d following oral administration; the second highest concentrations were displayed in gill and were still detectable until 35 d as well. These findings are similar to the DC depletion profiles in grass carp receiving the same treatment regimen under the same environmental temperature [25]. The concentration of DC in liver and gill all displayed the highest concentration in both species in comparison to plasma and other tissues.…”

Section: Discussionsupporting

confidence: 82%

“…Relative high concentration presenting in the gills is possible to be attributed to DC's reabsorption from excreta in water by gill. Subsequently, the concentrations in the liver of yellow catfish at the initial two sampling time points and in the gill of yellow catfish at the first time point were higher than that in liver and gill of grass carp at the same time stage [25]. Additionally, the concentration in liver of grass carp was higher than gill, and the same trend was present in yellow catfish except for the first sampling time point.…”

Section: Discussionmentioning

confidence: 74%

“…Many pharmacokinetic studies of DC have been reported in most of the veterinary animals, including pigs [14], chickens [15], calves [16], and horses [17], and a few aquatic animals, such as tilapia [18], grass carp [19], and channel catfish [20]. The tissue residue depletion of DC has also been investigated in pigs [21], hens [22], broilers [23], cattle [24], and grass carp [25]. However, limited information on the residue depletion kinetics of DC is available in yellow catfish.…”

Section: Introductionmentioning

confidence: 99%

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Withdrawal Interval Estimation of Doxycycline in Yellow Catfish (Pelteobagrus fulvidraco) Using an LC-MS/MS Method Based upon QuEChERS Sampling Preparation

Cheng

et al. 2021

Foods

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Limited information on residue depletion of doxycycline (DC) is available in yellow catfish (Pelteobagrus fulvidraco) using the determination of LC-MS/MS based upon a rapid and simple method of sample preparation. This study collected plasma and tissue samples of yellow catfish at pre-determined time points following 3-day consecutive oral administration of DC at 20 mg/kg. The samples were prepared using a QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) approach. The limit of detection and the limit of quantitation were 2.5 and 5 µg/kg or µg/L, respectively, for DC in plasma and tissues (e.g., muscle + skin, liver, kidney, and gill). The recoveries of DC ranged from 67.2% to 86.2%. The decision limit (CCα) and the detection capability (CCβ) were from 106.2 to 127.8 μg/kg or μg/L. The withdrawal times of DC in muscle + skin were estimated to be 22 d based on the guidelines in China and Europe and 27 d based on Japan’s standard. Overall, this study not only provides an efficient method to rapidly determine the DC concentrations in fish-derived tissues but also provides important information on the safety assessment of DC in aquatic animal-derived food products.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

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Withdrawal Interval Estimation of Doxycycline in Yellow Catfish (Pelteobagrus fulvidraco) Using an LC-MS/MS Method Based upon QuEChERS Sampling Preparation

Cheng

et al. 2021

Foods

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“…Numerous PK studies of DC have been conducted in chickens (6), ducks (7), pigs (8), sheep (9), and goats (10). Few studies have been implemented in fish, such as tilapia (11) and grass carp (12,13). However, there is limited available information on the BA of DC in channel catfish.…”

Section: Introductionmentioning

confidence: 99%

The Pharmacokinetics of Doxycycline in Channel Catfish (Ictalurus punctatus) Following Intravenous and Oral Administrations

Cheng

et al. 2020

Front. Vet. Sci.

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The objective of this study was to investigate the bioavailability (BA) and pharmacokinetics (PK) of doxycycline (DC) in channel catfish (Ictalurus punctatus) following a single intravenous injection at 5 mg/kg and a single oral administration at 50 mg/kg at 24 • C. The calculation of PK parameters was based on the software 3P97. The plasma samples were determined using ultra-performance liquid chromatography. Following oral administration, the multiple-peak phenomenon presented in concentration vs. time curve of DC at 2 h (107.01 mg/L), 8 h (55.07 mg/L), and 72 h (15.10 mg/L), respectively. The compartmental model cannot simulate the oral concentration vs. time profile beside a non-compartmental model. The calculated parameters of the elimination rate constant (λ z), the elimination half-life (t 1/2λz), and the area under the concentration vs. time curve (AUC 0-144) were 0.037 1/h, 18.91 h, and 2255.45 µg.h/mL, respectively. After intravenous administration, the concentration vs. time profile of DC was best described by a two-compartmental open model without absorption. The parameters of the distribution rate constant (α), the distribution half-life (t 1/2α), the elimination rate constant (β), the elimination half-life (t 1/2β), the apparent distribution volume at steady state (V ss), the total clearance (Cl) and the area under the concentration vs. time curve (AUC 0-∞) were 2.79 1/h, 0.25 h, 0.042 1/h, 16.51 h, 300.00 mL/kg, 14.00 mL/h/kg, and 364.99 µg.h/mL, respectively. For the calculation of BA values at the same condition, the data obtained from intravenous injection were also iterated based on a non-compartmental model, and the corresponding parameters of λ z , t 1/2λz , V z , Cl, and AUC 0-144 were 0.019 1/h, 36.26 h, 480.00 mL/kg, 9.10 mL/h/kg, and 514.45 µg.h/mL, respectively. However, there was a considerable difference in the same parameter when calculated by compartmental and non-compartmental approaches. Finally, the medium BA value of DC was evaluated to be 43.84%. This study provides future studies with a framework for determining the BA of DC in the development of a new formulation and provides information on the appropriate use of DC in aquaculture.

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“…Fishes are used as effective indicators of aquatic pollution due to their high sensitivity to environmental contaminants (Çilingir Yeltekin and Sağlamer 2019). In addition, pesticide residues in fish reach people in a short time because fish are consumed too much by humans (Xu et al 2019). Blood parameters are used as sensitive toxicity indicators.…”

Section: Introductionmentioning

confidence: 99%

Hematological and biochemical response in the blood of Alburnus tarichi (Actinopterygii: Cypriniformes: Cyprinidae) exposed to tebuconazole

Yeltekin¹,

Oğuz²,

Kankaya³

et al. 2020

Acta Ichthyol. Piscat.

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Tissue residue depletion kinetics and withdrawal time estimation of doxycycline in grass carp, Ctenopharyngodon idella, following multiple oral administrations

Cited by 23 publications

References 59 publications

Withdrawal Interval Estimation of Doxycycline in Yellow Catfish (Pelteobagrus fulvidraco) Using an LC-MS/MS Method Based upon QuEChERS Sampling Preparation

Withdrawal Interval Estimation of Doxycycline in Yellow Catfish (Pelteobagrus fulvidraco) Using an LC-MS/MS Method Based upon QuEChERS Sampling Preparation

The Pharmacokinetics of Doxycycline in Channel Catfish (Ictalurus punctatus) Following Intravenous and Oral Administrations

Hematological and biochemical response in the blood of Alburnus tarichi (Actinopterygii: Cypriniformes: Cyprinidae) exposed to tebuconazole

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