Tissue‐Resident Memory T Cells: Sequestered Immune Sensors and Effectors of Inflammation in Spondyloarthritis

Ritchlin, Christopher T.

doi:10.1002/art.41172

Cited by 6 publications

(14 citation statements)

References 25 publications

(25 reference statements)

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“…Recently, data has shown that TRM cells are responsible for the development of synovitis in PsA. However, they were not observed in rheumatoid arthritis [23].…”

Section: Tissue Resident Memory Cells In Psoriatic Arthritis (Psa)mentioning

confidence: 98%

“…Their expression occurs in inflamed tissues. In such situations, TRMs have an anti-inflammatory effect, which indicates the ambiguous nature of these cells [22,23].…”

Section: Tissue Resident Memory Cells (Trm)mentioning

confidence: 99%

“…Recirculation of memory T cells between the skin and circulation is a newly recognized immunological mechanism that plays an important role in the initiation of psoriasiform response [3,29,30] (Figure 3). Their particular pathogenicity is determined by the fact that they have the ability to produce IL-17 and IL-22, pro-inflammatory, key cytokines involved in this process [23,29]. The first study that highlighted the role of resident skin T cells in psoriasis was the experiment of Boyman et al [31].…”

Section: Tissue Resident Memory Cells In Psoriasismentioning

confidence: 99%

“…The heterodimeric marker molecule CD8+ (αEβ7) consists of CD103 and β7 subunits and plays a key role in the stability of CD8+ TRM cells by increasing the level of the Bcl-2 molecule with anti-apoptotic activity [8,13]. In contrast, TRM can produce granzyme B (serine protease), which can induce cellular apoptosis [23]. Moreover, IL-15 probably plays an important role in TRM cell survival [24].…”

Section: Tissue Resident Memory Cells In Psoriasismentioning

confidence: 99%

“…The synovial marker Tc17 was CXCR6, and elevated levels of CXCR6 CXCL16 ligand in PsA were found in synovial fluid, which could contribute to their retention in the joints [43]. However, there are many doubts if TRMs are responsible for the initiation of inflammation and whether it is the same phenotype that persists after the treatment [23].…”

Section: Tissue Resident Memory Cells In Psoriatic Arthritis (Psa)mentioning

confidence: 99%

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Immunological Memory of Psoriatic Lesions

Owczarczyk‐Saczonek

Krajewska–Włodarczyk

Kasprowicz-Furmańczyk

et al. 2020

IJMS

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The natural course of psoriasis is the appearance of new lesions in the place of previous ones, which disappeared after a successful therapy. Recent studies of psoriasis etiopathogenesis showed that after psoriatic plaques have disappeared, in healthy skin we can still find a trace of inflammation in the form of tissue resident memory cells (TRM). They are originally responsible for protection against viral and bacterial infections in non-lymphatic tissues. In psoriatic inflammation, they are characterized by heterogeneity depending on their origin. CD8+ T cells TRM are abundantly present in psoriatic epidermis, while CD4+ TRM preferentially populate the dermis. In psoriasis, epidermal CD8+ TRM cells express CLA, CCR6, CD103 and IL-23R antigen and produce IL-17A during ex vivo stimulation. However, CD4+ CD103+ TRM can also colonize the epidermis and produce IL-22 during stimulation. Besides T cells, Th22 and epidermal DCs proved that epidermal cells in healed skin were still present and functioning after several years of disease remission. It explains the clinical phenomenon of the tendency of psoriatic lesions to relapse in the same location and it allows to develop new therapeutic strategies in the future.

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“…Recently, data has shown that TRM cells are responsible for the development of synovitis in PsA. However, they were not observed in rheumatoid arthritis [23].…”

Section: Tissue Resident Memory Cells In Psoriatic Arthritis (Psa)mentioning

confidence: 98%

“…Their expression occurs in inflamed tissues. In such situations, TRMs have an anti-inflammatory effect, which indicates the ambiguous nature of these cells [22,23].…”

Section: Tissue Resident Memory Cells (Trm)mentioning

confidence: 99%

Section: Tissue Resident Memory Cells In Psoriasismentioning

confidence: 99%

Section: Tissue Resident Memory Cells In Psoriasismentioning

confidence: 99%

Section: Tissue Resident Memory Cells In Psoriatic Arthritis (Psa)mentioning

confidence: 99%

See 3 more Smart Citations

Immunological Memory of Psoriatic Lesions

Owczarczyk‐Saczonek

Krajewska–Włodarczyk

Kasprowicz-Furmańczyk

et al. 2020

IJMS

View full text Add to dashboard Cite

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Tissue-resident memory T cells: The key frontier in local synovitis memory of rheumatoid arthritis

Gao

Zhao

et al. 2022

Journal of Autoimmunity

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Update on the etiopathogenesis of psoriasis (Review)

et al. 2022

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Psoriasis is one of the most common immunemediated chronic inflammatory skin disorders, involving hyperproliferative keratinocytes and infiltration of T cells, dendritic cells, macrophages, and neutrophils. Multiple factors appear to play important roles in the pathogenesis of psoriasis. These environmental (e.g., infectious agents and trauma), genetic, and immunologic factors are reviewed in this article. Although the pathogenesis of psoriasis remains to be established, data suggesting immune cell dysregulation in the skin are available. The involvement of the immune system, particularly T cells, in the etiopathogenesis of psoriasis is discussed in this review, indicating a potential justification for innovative treatment intervention. Besides describing pathogenic T cells, the aim of the review was to assess the function of newly identified antimicrobial peptides (AMPs), interleukin (IL)-23, IL-17, and tissue resident memory cells (TRMs), and their role in psoriasis. Furthermore, new insights were presented regarding TRMs, a recently identified subset of memory T cells, and the role they play in the local memory of disease, making them a potential new therapeutic target in psoriasis. Finally, current developments in T-cell research and cytokine-targeted therapy for psoriasis treatment are reviewed. Contents 1. Introduction 2. Research methods 3. Epidemiology 4. Etiology 5. Pathogenesis 6. Conclusions

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Tissue‐Resident Memory T Cells: Sequestered Immune Sensors and Effectors of Inflammation in Spondyloarthritis

Cited by 6 publications

References 25 publications

Immunological Memory of Psoriatic Lesions

Immunological Memory of Psoriatic Lesions

Tissue-resident memory T cells: The key frontier in local synovitis memory of rheumatoid arthritis

Update on the etiopathogenesis of psoriasis (Review)

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