Tissue-resident macrophage inflammaging aggravates homeostasis dysregulation in age-related diseases

Yue, Ziqi; Nie, Luningxiao; Zhang, Peng; Chen, Qin; Lv, Qingguo; Wang, Qi

doi:10.1016/j.cellimm.2020.104278

Cited by 11 publications

(9 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Macrophages are central to the development of inflammaging [ 34 ]. We observed that the number of BM nucleated cells was significantly increased in the aged (78–104 weeks old) compared to the young (8–12 weeks old) mice (aBM and yBM, respectively) ( p < 0.001) ( Figure 1 a).…”

Section: Resultsmentioning

confidence: 99%

Preconditioned Mesenchymal Stromal Cell-Derived Extracellular Vesicles (EVs) Counteract Inflammaging

Görgün

Africano

Ciferri

et al. 2022

Cells

View full text Add to dashboard Cite

Inflammaging is one of the evolutionarily conserved mechanisms underlying aging and is defined as the long-term consequence of the chronic stimulation of the innate immune system. As macrophages are intimately involved in initiating and regulating the inflammatory process, their dysregulation plays major roles in inflammaging. The paracrine factors, and in particular extracellular vesicles (EVs), released by mesenchymal stromal cells (MSCs) retain immunoregulatory effects on innate and adaptive immune responses. In this paper, we demonstrate that EVs derived from MSCs preconditioned with hypoxia inflammatory cytokines exerted an anti-inflammatory role in the context of inflammaging. In this study, macrophages isolated from aged mice presented elevated pro-inflammatory factor levels already in basal conditions compared to the young counterpart, and this pre-activation status increased when cells were challenged with IFN-γ. EVs were able to attenuate the age-associated inflammation, inducing a decrease in the expression of TNF-α, iNOS, and the NADase CD38. Moreover, we demonstrate that EVs counteracted the mitochondrial dysfunction that affected the macrophages, reducing lipid peroxidation and hindering the age-associated impairment of mitochondrial complex I activity, oxygen consumption, and ATP synthesis. These results indicate that preconditioned MSC-derived EVs might be exploited as new anti-aging therapies in a variety of age-related diseases.

show abstract

Section: Resultsmentioning

confidence: 99%

Preconditioned Mesenchymal Stromal Cell-Derived Extracellular Vesicles (EVs) Counteract Inflammaging

Görgün

Africano

Ciferri

et al. 2022

Cells

View full text Add to dashboard Cite

show abstract

“…94 Dysfunction of cutaneous macrophages can also contribute to inflammaging and age-associated disorders. 95,96 Although whether epidermal dysfunction is linked to altered macrophage function in the skin is unknown, these lines of evidence suggest the skin's contribution to both inflammaging and type 2 diabetes.…”

Section: Perspectivementioning

confidence: 99%

“…Likewise, improvements in epidermal function with a topical emollient (Atopalm® MLE cream) lower the levels of cytokines in the circulation of aged humans 94 . Dysfunction of cutaneous macrophages can also contribute to inflammaging and age‐associated disorders 95,96 . Although whether epidermal dysfunction is linked to altered macrophage function in the skin is unknown, these lines of evidence suggest the skin's contribution to both inflammaging and type 2 diabetes.…”

Section: Perspectivementioning

confidence: 99%

Alterations in epidermal function in type 2 diabetes: Implications for the management of this disease

Man

Wakefield

Mauro

et al. 2022

Journal of Diabetes

View full text Add to dashboard Cite

Epidermal function is regulated by numerous exogenous and endogenous factors, including age, psychological stress, certain skin disorders, ultraviolet irradiation and pollution, and epidermal function itself can regulate cutaneous and extracutaneous functions. The biophysical properties of the stratum corneum reflect the status of both epidermal function and systemic conditions. Type 2 diabetes in both murine models and humans displays alterations in epidermal functions, including reduced levels of stratum corneum hydration and increased epidermal permeability as well as delayed permeability barrier recovery, which can all provoke and exacerbate cutaneous inflammation.Because inflammation plays a pathogenic role in type 2 diabetes, a therapy that improves epidermal functions could be an alternative approach to mitigating type 2 diabetes and its associated cutaneous disorders.

show abstract

“…Since Mϕ are the most abundant immune cell type in the skin, and this tissue is directly exposed to several environmental factors, such as UV radiation, genomic instability could be a central hallmark of aging in aged Mϕ; after all, numerous DNA injuries can lead to accumulated damage and altered Mϕ function in this tissue [37]. This in turn can lead to altered gene expression of molecules such as cytokines, MHC class II, transcription factors, an exacerbated production of reactive oxygen species (ROS) [15], and NF-κB signaling in response to DNA damage [38], rendering Mϕ more susceptible to apoptosis, impairing their phagocytosis function [39], and contributing to inflammaging [40].…”

Section: Genomic Instabilitymentioning

confidence: 99%

Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging

Guimarães

Almeida

Santos

et al. 2021

Cells

View full text Add to dashboard Cite

The skin is our largest organ and the outermost protective barrier. Its aging reflects both intrinsic and extrinsic processes resulting from the constant insults it is exposed to. Aging in the skin is accompanied by specific epigenetic modifications, accumulation of senescent cells, reduced cellular proliferation/tissue renewal, altered extracellular matrix, and a proinflammatory environment favoring undesirable conditions, including disease onset. Macrophages (Mφ) are the most abundant immune cell type in the skin and comprise a group of heterogeneous and plastic cells that are key for skin homeostasis and host defense. However, they have also been implicated in orchestrating chronic inflammation during aging. Since Mφ are related to innate and adaptive immunity, it is possible that age-modified skin Mφ promote adaptive immunity exacerbation and exhaustion, favoring the emergence of proinflammatory pathologies, such as skin cancer. In this review, we will highlight recent findings pertaining to the effects of aging hallmarks over Mφ, supporting the recognition of such cell types as a driving force in skin inflammaging and age-related diseases. We will also present recent research targeting Mφ as potential therapeutic interventions in inflammatory skin disorders and cancer.

show abstract

Tissue-resident macrophage inflammaging aggravates homeostasis dysregulation in age-related diseases

Cited by 11 publications

References 132 publications

Preconditioned Mesenchymal Stromal Cell-Derived Extracellular Vesicles (EVs) Counteract Inflammaging

Preconditioned Mesenchymal Stromal Cell-Derived Extracellular Vesicles (EVs) Counteract Inflammaging

Alterations in epidermal function in type 2 diabetes: Implications for the management of this disease

Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging

Contact Info

Product

Resources

About