Tissue Remodeling and Nonendometrium-Like Menstrual Cycling Are Hallmarks of Peritoneal Endometriosis Lesions

Sohler, Florian; Sommer, Anette; Wachter, David; Agaimy, Abbas; Fischer, Oliver M.; Renner, Stefan P.; Burghaus, Stefanie; Fasching, Peter A.; Beckmann, Matthias W.; Fuhrmann, Ulrike; Strick, Reiner; Strissel, Pamela L.

doi:10.1177/1933719112451147

Cited by 17 publications

(16 citation statements)

References 66 publications

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“…This has been supported by a morphometric study showing that tight junctions were missing or disrupted in endometrioma compared to eutopic endometrium [39]. In a more recent study, microarray analyses revealed an upregulation of transcripts of JAM-B and JAM-C and of claudin-1, -5 and -11 and a downregulation of ZO-3, occludin and claudin-3, -4 and -7 in peritoneal endometriotic lesions compared to the corresponding eutopic endometrium [104]. However, these observations were not validated by PCR or immunohistochemical staining.…”

Section: Direct Cell–cell Interactions In Endometrial Pathophysiologymentioning

confidence: 76%

Direct Cell–Cell Interactions in the Endometrium and in Endometrial Pathophysiology

Grund

Grümmer

2018

IJMS

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Cell contacts exhibit a considerable influence on tissue physiology and homeostasis by controlling paracellular and intercellular transport processes, as well as by affecting signaling pathways. Since they maintain cell polarity, they play an important role in cell plasticity. The knowledge about the junctional protein families and their interactions has increased considerably during recent years. In contrast to most other tissues, the endometrium undergoes extensive physiological changes and reveals an extraordinary plasticity due to its crucial role in the establishment and maintenance of pregnancy. These complex changes are accompanied by changes in direct cell–cell contacts to meet the various requirements in the respective developmental stage. Impairment of this sophisticated differentiation process may lead to failure of implantation and embryo development and may be involved in the pathogenesis of endometrial diseases. In this article, we focus on the knowledge about the distribution and regulation of the different junctional proteins in the endometrium during cycling and pregnancy, as well as in pathologic conditions such as endometriosis and cancer. Decoding these sophisticated interactions should improve our understanding of endometrial physiology as well as of the mechanisms involved in pathological conditions.

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Section: Direct Cell–cell Interactions In Endometrial Pathophysiologymentioning

confidence: 76%

Direct Cell–Cell Interactions in the Endometrium and in Endometrial Pathophysiology

Grund

Grümmer

2018

IJMS

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“…Estrogen and progesterone play an important role in the development and maintenance of endometriosis. Although endometriotic cells do not have high proliferative activity, supported by Ki67 studies and cell cycle gene expression, stimulation through steroid hormones along with growth factors promotes steady and slow growth [ 43 – 45 ]. Additionally in a mouse model stimulation with estrogen led to an increase of MMP2 and promoted ectopic implantation of endometrial tissue [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Adhesion, Proliferation, and Invasion of Primary Endometriosis and Endometrial Stromal and Ovarian Carcinoma Cells by a Nonhyaluronan Adhesion Barrier Gel

Renner¹,

Strissel²,

Beckmann³

et al. 2015

BioMed Research International

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Endometriosis is a chronic disease of women in the reproductive age, defined as endometrial cells growing outside of the uterine cavity and associated with relapses. Relapses are hypothesized to correlate with incomplete surgical excision or result from nonrandom implantation of new endometrial implants in adjacent peritoneum. Thus, surgical excision could lead to free endometriotic cells or tissue residues, which readhere, grow, and invade into recurrent lesions. Barrier agents are frequently used to prevent postoperative adhesions. We tested if the absorbable cell adhesion barrier gel Intercoat consisting of polyethylene oxide and sodium carboxymethyl cellulose could inhibit cellular adhesion, proliferation, and invasion of primary endometriosis and endometrial cells. Due to an association of endometriosis with ovarian carcinoma, we tested two ovarian carcinoma cell lines. Prior to cell seeding, a drop of the barrier gel was placed in cell culture wells in order to test inhibition of adherence and proliferation or coated over a polymerized collagen gel to assay for prevention of invasion. Results showed that the barrier gel significantly inhibited cell adherence, proliferation, and invasion of endometriosis and endometrial stromal cells as well as ovarian carcinoma cells in culture. Our findings could help to prevent local cell growth/invasion and possible consequent recurrences.

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“…To identify co-expressed mRNAs that were differentially expressed lncRNAs and lncRNA in endometriosis, the raw CEL files for GSE7305 (10 normal samples and 10 endometriosis samples) ( 18 ), GSE7846 (5 normal samples and 5 endometriosis samples) ( 19 ) and GSE29981 (20 endometriosis samples) were downloaded from GEO ( ), and E-MTAB-694 (17 normal samples and 18 endometriosis samples) ( 20 ) from ArrayExpress ( ). The limma and Affy packages were used to read and process the raw CEL files.…”

Section: Methodsmentioning

confidence: 99%

Identification of LINC01279 as a cell cycle‑associated long non‑coding RNA in endometriosis with GBA analysis

et al. 2018

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Endometriosis affects 6–10% of women of reproductive age. Though a significant amount of research has explored the pathogenesis of endometriosis, little is clear. Elucidating the mechanisms is urgently required for improving the therapeutic efficiency of endometriosis treatment. Long non-coding RNAs (lncRNAs) have recently acquired extensive attention as regulatory components in a variety of biological processes and diseases. However, the functions of many lncRNAs in endometriosis are poorly understood. Therefore, the exploration of the dysregulated genes in endometriosis, particularly lncRNAs, is of importance. In the present study, datasets for endometriosis, including GSE7305, GSE7846, GSE29981 and E-MTAB-694, were downloaded from Gene Expression Omnibus and ArrayExpress. Then, the limma and Affy packages were used to analyze the CEL file. The RankProd method was used to conduct meta-analysis. Long intergenic non-protein coding RNA 1279 (LINC01279) was significantly upregulated in the three datasets, and was the most upregulated lncRNA as determined by the RankProd method. Gene set enrichment and Gene Ontology analyses were conducted, which revealed that LINC01279 is likely to function as a cell cycle mediator in endometriosis. Finally, it was identified that LINC01279 is strongly associated with certain previously identified key factors in the development of endometriosis, including cyclin-dependent kinase 14 and C-X-C motif chemokine ligand 12. Thus, it was demonstrated that LINC01279 may be associated with the pathogenesis of endometriosis. This may potentially represent a target in the therapy of endometriosis.

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Tissue Remodeling and Nonendometrium-Like Menstrual Cycling Are Hallmarks of Peritoneal Endometriosis Lesions

Cited by 17 publications

References 66 publications

Direct Cell–Cell Interactions in the Endometrium and in Endometrial Pathophysiology

Direct Cell–Cell Interactions in the Endometrium and in Endometrial Pathophysiology

Inhibition of Adhesion, Proliferation, and Invasion of Primary Endometriosis and Endometrial Stromal and Ovarian Carcinoma Cells by a Nonhyaluronan Adhesion Barrier Gel

Identification of LINC01279 as a cell cycle‑associated long non‑coding RNA in endometriosis with GBA analysis

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