Tissue regeneration: A new property of mesoporous materials

Izquierdo‐Barba, Isabel; Ruiz‐González, Luisa; Doadrio, A.; González‐Calbet, José M.; Vallet‐Regí, María

doi:10.1016/j.solidstatesciences.2005.04.003

Cited by 200 publications

(119 citation statements)

References 22 publications

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“…More importantly, a precise control over the porosity, pore dimensions and internal pore architecture of bioceramics on different length scales is essential for understanding of the structure-bioactivity relationship and the rational design of better bone-forming biomaterials [483,490,491]. Namely, in antibiotic charging experiments, a calcium orthophosphate bioceramics with nanodimensional (< 100 nm) pores showed a much higher charging capacity (1621 μg/g) than that of commercially available calcium orthophosphate (100 μg/g), which did not contain nanodimensional porosity [478].…”

Section: Porositymentioning

confidence: 99%

Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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Section: Porositymentioning

confidence: 99%

Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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“…A series of mesoporous bioactive materials, such as mesoporous SiO 2 CaOP 2 O 5 bioactive glasses, 1820) mesoporous silica with different pore sizes, 21) mesoporous silica hydroxyapatite composite 22) and mesoporous amorphous calcium silicate 23,24) have been widely studied. Solgel process provides an available way to prepare these biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Mesoporous SiO2–CaO–P2O5 Bioactive Glass by Sol–Gel Process

Lü

et al. 2013

Mater. Trans.

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Ordered mesoporous SiO 2 CaOP 2 O 5 bioactive glass with a highly specific surface area has been synthesized through a solgel process in the presence of a nonionic triblock copolymer acting as a template. The amorphous silicate can be detected on the mesoporous SiO 2 CaOP 2 O 5 bioactive glass. The mesoporous SiO 2 CaOP 2 O 5 bioactive glass exhibits the type IV isotherm curve with average pore size of 5.3 nm and high specific surface area of 317.24 m 2

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“…The ability to bond with living bone through a HAP interface layer on their surface is a significant characteristic of MMBGs, which has been widely studied both in vitro and in vivo [43]. The deposition/growth of HAP of the scaffolds in vitro has been investigated here by soaking them in SBF at 37°C.…”

Section: Bioactivity Of the Hierarchically Porous Bioactive Glass Scamentioning

confidence: 99%

Synthesis of hierarchically porous bioactive glasses using natural plants as template for bone tissue regeneration

et al. 2012

J Sol-Gel Sci Technol

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A series of highly ordered hierarchically porous silica and bio-glasses materials with macropore size of 8-1,000 lm and mesopore size of 3.1-5.6 nm have been synthesized using six plant based materials as templates. However, the as-obtained porous structure was reported for the first time with interconnected 3D macropore up to 1,000 lm. The porous silica materials were used as the host for drug loading and release, which showed a good sustained delivery function. The as-synthesized bio-glasses materials indicated the highly bioactive capability in the bone regeneration. This method can be utilized to synthesize other multi-porous bioactive glasses using different plants as templates for bone tissue repairing.

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Tissue regeneration: A new property of mesoporous materials

Cited by 200 publications

References 22 publications

Medical Application of Calcium Orthophosphate Bioceramics

Medical Application of Calcium Orthophosphate Bioceramics

Synthesis and Characterization of Mesoporous SiO<sub>2</sub>–CaO–P<sub>2</sub>O<sub>5</sub> Bioactive Glass by Sol–Gel Process

Synthesis of hierarchically porous bioactive glasses using natural plants as template for bone tissue regeneration

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Tissue regeneration: A new property of mesoporous materials

Cited by 200 publications

References 22 publications

Medical Application of Calcium Orthophosphate Bioceramics

Medical Application of Calcium Orthophosphate Bioceramics

Synthesis and Characterization of Mesoporous SiO<sub>2</sub>&ndash;CaO&ndash;P<sub>2</sub>O<sub>5</sub> Bioactive Glass by Sol&ndash;Gel Process

Synthesis of hierarchically porous bioactive glasses using natural plants as template for bone tissue regeneration

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Synthesis and Characterization of Mesoporous SiO<sub>2</sub>–CaO–P<sub>2</sub>O<sub>5</sub> Bioactive Glass by Sol–Gel Process