Tissue Reactions to Injected Silicone Liquids

Adverse reactions to injectable soft tissue fillers

“…190 Local reactions at the sites of injections include pain, erythema, ecchymosis, hyperpigmentation and hypopigmentation of the overlying skin, induration and inflammatory nodules, also named ''siliconomas,'' which are sometimes resolved with dystrophic scars. 121,178,[191][192][193][194][195][196][197][198] The diagnosis is not always clinically suspected, because these reactions may develop many years after the tissue augmentation. Granulomas have also been described in the skin at the point of entry of acupuncture and venepuncture needles coated with silicone and particles of silicone have been detected in macrophages with radiographic microanalysis.…”

Silicone Granulomas in the Setting of Acupuncture with Silicone-Coated Needles

“…Silicone-coated needles have become increasingly popular in alternative medicine techniques such as acupuncture to ease the insertion of needles. It has been well established that silicone can lead to a foreign body granulomatous reaction in the skin with the first histopathologic cases reported in 1964 [2]. Herein, we present what is believed to be the third reported case of silicone granulomas secondary to silicone-coated acupuncture needles [3,4].…”

Solid noninfectious growing masses over cerebrospinal fluid shunts: report of 3 cases

“…Winer et al noted granuloma foreign-body reaction in the macrophages, histiocytes, epithelioid cells, lymphocytes, plasma cells, and giant multinucleated cells in the subcutaneous tissues following the injection of liquid silicone in humans. 9 They coined the term "siliconoma" to describe this process and subsequently reproduced these changes following intraperitoneal silicone injections in mice. 8 However, none of the reports indicate the presence of progressively enlarging masses that created such significant anatomical distortion as that which occurred in our 3 patients.…”