Tissue Reaction and Hemostatic Characteristics — Fibrin Sealant Versus Polidocanol: Experimental and Clinical Results

Biological in vitro effects of fibrin glue: fibroblast proliferation, expression and binding of growth factors

“…Fibrin glue may even accelerate scar formation and lacks toxic side effects. Previous studies suggest that fibrin glue promotes the formation of granulation tissue (3) and changes its composition by increasing the density of fibroblasts occurring together with angioblasts (4).…”

Effects of Hemostatic Agents on Fibroblast Cells

“…1 Each of these plants has various effects on blood cells, endothelium, angiogenesis, cell proliferation, and cellular mediators. 8,9 Tranexamic acid (tAMCHA) is an antifibrinolytic agent, which inhibits the transformation of plasminogen into plasmin and is used widely even as a topical mouthwash in patients who have postoperative prolonged bleeding after oral surgery. 1 Fibrin glue is a material used as a hemostatic agent and is known to increase granulation tissue formation and vascularization.…”