Tissue polypeptide specific antigen in human breast cyst fluids

Mannello, Ferdinando; Bocchiotti, GD; Troccoli, R

doi:10.1016/0277-5379(91)91534-p

Cited by 1 publication

(1 citation statement)

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“…Estrogens do not modulate EGF expression [193] whereas progesterone depresses the androgen-stimulated synthesis [199]. Epithelial membrane antigen (EMA) [123] a-Fetoprotein [173] b-Human chorionic gonadotropin (b-hCG) [173,176,[181][182][183][184][185] Mucinous carcinoma associated antigen (MCA) [186] Prostate-specific antigen (PSA) [162][163][164][165][166][167][168][169][170][171] Tissue-polypeptide antigen (TPA) [176] Tissue-polypeptide specific antigen (TPS) [187,188] Tumor-associated glycoprotein 72 (CA72 or TAG-72)…”

Section: Growth Factors and Their Binding Proteinsmentioning

confidence: 99%

Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies

Mannello

Tonti

Papa

2005

Breast Cancer Res Treat

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For more than one and a half century the cystic disease of the breast has been recognized as the most frequent female benign breast lesion. Although some conundrums and controversies exist about the relation between gross cysts and breast cancer, recent evidence suggests that the multidisciplinary study of gross cystic breast disease (GCBD) may be a powerful tool for predicting the natural history of the multifaceted gross cyst pathology. A lot of papers have been published on breast cyst fluids (BCF) concerning biochemical, hormonal and morphological aspects, demonstrating that the intracystic fluid contains a wide variety of components (such as ions, lipids, proteins, enzymes, growth factors and antigens) and suggesting that their profile provides additional knowledge on both physiopathology and etiologic pathways of human gross cystic breast disease. The aim of this overview is the critical evaluation of all data accumulated in the last thirty years, in order to highlight the utility of biochemical and epidemiological studies to identify gross cysts, if any, at higher breast cancer risk.

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