Tissue perfusion in neonates undergoing open-heart surgery using autologous umbilical cord blood or donor blood components

Abstract

Despite the fact that the oxyhemoglobin dissociation curve is shifted leftward in patients who receive autologous umbilical cord blood, tissue oxygen delivery appears to be preserved in neonates who undergo open-heart surgery using autologous umbilical cord blood.

Umbilical cord blood as a source for red‐blood‐cell transfusion in neonatology: a systematic review

“…Several authors suggested the possibility of using cord blood as an alternative to adult blood transfusion . We reported four case reports and thirteen case series .…”

“…Several authors suggested the possibility of using cord blood as an alternative to adult blood transfusion . We reported four case reports and thirteen case series . Transfusions were performed because of neonatal anaemia in seven cases , surgical indications such as congenital malformations and cardiac surgeries in eight cases.…”

“…We reported four case reports and thirteen case series . Transfusions were performed because of neonatal anaemia in seven cases , surgical indications such as congenital malformations and cardiac surgeries in eight cases. Two papers reported an experience in both anaemic and surgical patients .…”

“…The low collected volume appears as the main limit of the UCB autologous transfusion strategy: starting a program to use UCB units for transfusion should take account for criteria to identify neonates with a high probability of collecting units with an adequate volume. Since autologous UCB mainly covers one single transfusion dose, it appears suitable for full‐term infants with prenatal diagnosis of diseases requiring surgical interventions soon after the birth . For example, in cardiac surgery, Chasovskyi et al .…”

“…For example, in cardiac surgery, Chasovskyi et al . reported that UCB collected at delivery could be used for autologous transfusion in all patients with a prenatal diagnosis of arterial transposition undergoing surgery or for the priming of the cardio‐vascular bypass .…”