Relationship Between Antiinflammatory Cytokine Interleukin-10 and Lactate Concentrations in Neonates Undergoing the Arterial Switch Operation

Chasovskyi, Kyrylo; Жовнір, В. А.; Vorobiova, Ganna; Yemets, Illya

doi:10.1016/j.athoracsur.2015.09.087

Cited by 2 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The concomitant elevation of IL‐10 and other proinflammatory interleukins in controls together with the increased incidence of pulmonary inflammation and prolonged hospitalization indicates the immunosuppressive role of IL‐10, which impairs the immune system to counter‐regulate the inflammatory process [20, 21]. Previous evidence revealed that excessive production of IL‐10 immediately after the surgery contributes to sepsis‐induced immunosuppression and is associated with prolonged ICU stay and higher mortality [22]. On the other hand, vagus nerve stimulation resulted in downregulation of IL‐6 with simultaneous elevation of IL‐10.…”

Section: Discussionmentioning

confidence: 99%

Transcutaneous Stimulation of Auricular Branch of the Vagus Nerve Attenuates the Acute Inflammatory Response After Lung Lobectomy

Salama

Akan²,

Mueller

2020

World j. surg.

View full text Add to dashboard Cite

Objectives Systemic inflammation is a potentially debilitating complication of thoracic surgeries with significant physical and economic morbidity. There is compelling evidence for the role of the central nervous system in regulating inflammatory processes through humoral mechanisms. Activation of the afferent vagus nerve by cytokines triggers anti-inflammatory responses. Peripheral electrical stimulation of the vagus nerve in vivo during lethal endotoxemia in rats inhibited tumor necrosis factor synthesis and prevented shock development. However, the vagal regulatory role of systemic inflammation after lung lobectomy is unknown. Methods One hundred patients who underwent lobectomy via thoracotomy were recruited and equally randomized to treated group or controls. Intermittent stimulation of the auricular branch of vagus nerve in the triangular fossa was applied in the treated group using neurostimulator V (Ducest Ò , Germany), starting 24 h preoperatively and continued till the 4th postoperative day (POD). Inflammatory interleukins (IL) were analyzed using ELISA preoperatively, on the 1st and 4th POD. Results On the 1st POD, patients who underwent neurostimulation had reduced serum concentrations of CRP (p = 0.01), IL6 (p = 0.02) but elevated IL10 (p = 0.03) versus controls. On the 4th POD, serum concentrations of CRP, IL6 and IL10 were similar in both groups. Moreover, the treated group was associated with lower incidence of pneumonia (p = 0.04) and shorter hospitalization time (p = 0.04) versus controls. Conclusions Modulations in the brain stem caused by noninvasive transcutaneous stimulation of the vagus nerve after lung lobectomy attenuate the acute postsurgical inflammatory response by the regulation of IL6 and IL10, resulting in reduced incidence of postoperative pneumonia and short hospitalization time. Clinical Trial Registry Number NCT03204968.

show abstract

Section: Discussionmentioning

confidence: 99%

Transcutaneous Stimulation of Auricular Branch of the Vagus Nerve Attenuates the Acute Inflammatory Response After Lung Lobectomy

Salama

Akan²,

Mueller

2020

World j. surg.

View full text Add to dashboard Cite

show abstract

Novel Biomarkers in Cardiovascular Surgery

et al. 2021

View full text Add to dashboard Cite

Cardiovascular disease includes health problems related to the heart, arteries and veins and is a significant healthcare problem worldwide. Cardiovascular disease may be acute or chronic and relapses are frequent. Biomarkers involved in this field may help clinicians and surgeons in diagnosis and adequate decision making. Relevant articles searched in the following databases Medline, Scopus, ScienceDirect, were retrieved and analysed. Several biomarkers have been identified and we analyzed those of most importance from a clinical and surgical point of view. Biomarkers can better identify high-risk individuals, facilitate follow-up process, provide information regarding prognosis and better tailor the most appropriate surgical treatment.

show abstract

Relationship Between Antiinflammatory Cytokine Interleukin-10 and Lactate Concentrations in Neonates Undergoing the Arterial Switch Operation

Cited by 2 publications

References 16 publications

Transcutaneous Stimulation of Auricular Branch of the Vagus Nerve Attenuates the Acute Inflammatory Response After Lung Lobectomy

Transcutaneous Stimulation of Auricular Branch of the Vagus Nerve Attenuates the Acute Inflammatory Response After Lung Lobectomy

Novel Biomarkers in Cardiovascular Surgery

Contact Info

Product

Resources

About