Tissue‐Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction

Yang, Yunlong; Zhang, Jieyuan; Liu, Zhenzhen; Lin, Qiuning; Liu, Xiaolin; Bao, Chunyan; Wang, Yang; Zhu, Linyong

doi:10.1002/adma.201505336

Cited by 199 publications

(182 citation statements)

References 49 publications

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“…To enhance mechanical performance and tissue integration, additional crosslinking chemistries beyond methacrylation may be explored. For example, Yang et al . demonstrated the viability of an imide‐crosslinking reaction to form hydrogels by functionalizing a polymer with a nitrobenzene to react with primary amine groups upon activation with UV irradiation.…”

Section: Discussionmentioning

confidence: 99%

“…To enhance mechanical performance and tissue integration, additional crosslinking chemistries beyond methacrylation may be explored. For example, Yang et al 59 demonstrated the viability of an imide-crosslinking reaction to form hydrogels by functionalizing a polymer with a nitrobenzene to react with primary amine groups upon activation with UV irradiation. Given that the hydrogel could dually crosslink to amino-functionalized polymers and primary amines present in tissues, they demonstrated a biocompatible hydrogel chemistry that promoted better tissue integration and faster wound repair.…”

Section: Discussionmentioning

confidence: 99%

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Cartilage extracellular matrix as a biomaterial for cartilage regeneration

Kiyotake

Beck

Detamore

2016

Annals of the New York Academy of Sciences

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The extracellular matrix (ECM) of various tissues possesses the model characteristics that biomaterials for tissue engineering strive to mimic; however, owing to the intricate hierarchical nature of the ECM, it has yet to be fully characterized and synthetically fabricated. Cartilage repair remains a challenge because the intrinsic properties that enable its durability and long-lasting function also impede regeneration. In the last decade, cartilage ECM has emerged as a promising biomaterial for regenerating cartilage, partly because of its potentially chondroinductive nature. As this research area of cartilage matrix-based biomaterials emerged, investigators facing similar challenges consequently developed convergent solutions in constructing robust and bioactive scaffolds. This review discusses the challenges, emerging trends, and future directions of cartilage ECM scaffolds, including a comparison between two different forms of cartilage matrix: decellularized cartilage (DCC) and devitalized cartilage (DVC). To overcome the low permeability of cartilage matrix, physical fragmentation greatly enhances decellularization, although the process itself may reduce the chondroinductivity of fabricated scaffolds. The less complex processing of a scaffold composed of DVC, which has not been decellularized, appears to have translational advantages and potential chondroinductive and mechanical advantages over DCC, without detrimental immunogenicity, to ultimately enhance cartilage repair in a clinically relevant way.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cartilage extracellular matrix as a biomaterial for cartilage regeneration

Kiyotake

Beck

Detamore

2016

Annals of the New York Academy of Sciences

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“…The sealant composed of chitosan functionalized with lactobionic acid and azide moieties showed high sealing effect compared with fibrin sealant, and nontoxicity for human cells . The sealant using hyaluronic acid functionalized with o‐nitrobenzene also provided both sealing effect and biocompatible gelation system . However, these materials have not yet been designed to enhance the interfacial bonding strength between sealant materials and tissues.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Sealing by Hydrophobic Modification of Alaska Pollock‐Derived Gelatin‐Based Surgical Sealants for the Treatment of Pulmonary Air Leaks

Mizuta

Taguchi

2016

Macromolecular Bioscience

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Pulmonary air leaks are medical complications of thoracic surgery for which fibrin sealant is the main treatment. In this study, innovative sealants based on hydrophobically modified Alaska pollock-derived gelatin (hm-ApGltn) and a poly(ethylene)glycol-based 4-armed cross-linker (4S-PEG) have been developed and their burst strengths have been evaluated using fresh rat lung. The developed sealants show higher lung burst strength compared with the nonmodified original ApGltn (Org-ApGltn)-based sealant and a commercial fibrin sealant. The maximum burst strength of the hm-ApGltn-based sealant is 1.6-fold higher than the Org-ApGltn-based sealant (n = 5, p < 0.05), and 2.1-fold higher than the commercial fibrin sealant (n = 5, p < 0.05). Cell culture experiments show that modification of ApGltn with cholesteryl or stearoyl groups effectively enhances anchoring to the cell surface. In addition, binding constants between hm-ApGltn and extracellular matrix proteins such as fibronectin and fibrillin are increased. Therefore, the new hm-ApGltn/4S-PEG-based sealant has the potential for applications in thoracic surgery.

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“…Recently, increasing efforts are devoted to the design and fabrication of self-healing hydrogels through dynamic covalent bonds because dynamic covalent bonds combine the reversibility of noncovalent bonds and the stability of covalent bonds. As a result, self-healing hydrogels based on phenylboronate ester [20,21], disulfide [22,23], acyhydrazone [24,25], and imine [26,27] have been successfully developed. Among these dynamic covalent bonds, imine bonds can be simply prepared between amino and aldehyde groups under physiological conditions.…”

Section: Introductionmentioning

confidence: 99%

Injectable and Self-Healing Chitosan Hydrogel Based on Imine Bonds: Design and Therapeutic Applications

Chen

et al. 2018

IJMS

119

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Biological tissues can automatically repair themselves after damage. Examples include skin, muscle, soft tissue, etc. Inspired by these living tissues, numerous self-healing hydrogels have been developed recently. Chitosan-based self-healing hydrogels constructed via dynamic imine bonds have been widely studied due to their simple preparation, good biocompatibility, and automatic reparability under physiological conditions. In this mini-review, we highlighted chitosan-based self-healing hydrogels based on dynamic imine chemistry, and provided an overview of the preparation of these hydrogels and their bioapplications in cell therapy, tumor therapy, and wound healing.

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Tissue‐Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction

Cited by 199 publications

References 49 publications

Cartilage extracellular matrix as a biomaterial for cartilage regeneration

Cartilage extracellular matrix as a biomaterial for cartilage regeneration

Enhanced Sealing by Hydrophobic Modification of Alaska Pollock‐Derived Gelatin‐Based Surgical Sealants for the Treatment of Pulmonary Air Leaks

Injectable and Self-Healing Chitosan Hydrogel Based on Imine Bonds: Design and Therapeutic Applications

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