Injectable and Self-Healing Chitosan Hydrogel Based on Imine Bonds: Design and Therapeutic Applications

Xu, Yanshuang; Li, Yongsan; Chen, Qiaomei; Fu, Lihua; Tao, Lei; Wei, Yen

doi:10.3390/ijms19082198

Cited by 121 publications

(73 citation statements)

References 51 publications

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“…The swelling ratios of gels ranged from (− 42.89 ± 6.25) %, (− 47.25 ± 1.47) %, (− 39.21 ± 1.53) % in the C1, C2, and C3, respectively. Some studies [11,26] demonstrated that the crosslinking degree, the formation of ionic bonds, and hydrophilicity of network of hydrogels influence the swelling. In the swelling kinetics assays, the hydrogel behavior is powerfully influenced by the presence of cations in the immersion solution [11].…”

Section: Physicochemical Propertiesmentioning

confidence: 99%

“…Some studies [11,26] demonstrated that the crosslinking degree, the formation of ionic bonds, and hydrophilicity of network of hydrogels influence the swelling. In the swelling kinetics assays, the hydrogel behavior is powerfully influenced by the presence of cations in the immersion solution [11]. These cations form ionic bonds that increase the crosslinking degree and lower the water uptake ratio.…”

Section: Physicochemical Propertiesmentioning

confidence: 99%

“…An injectable hydrogel is a class of hydrogel, which can convert from solution to gel in situ upon physical or chemical stimuli. Therefore, these hydrogels can be introduced into a defined position of the body through a minimally invasive method [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Enzymatically crosslinked tyramine-gellan gum hydrogels as drug delivery system for rheumatoid arthritis treatment

Oliveira

Gonçalves

Shin

et al. 2020

Drug Deliv. and Transl. Res.

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Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint synovial inflammation, as well as cartilage and bone tissue destruction. Current strategies for the treatment of RA can reduce joint inflammation, but the treatment options still represent stability concerns since they are not sufficient and present a fast clearing. Thus, several drug delivery systems (DDS) have been advanced to tackle this limitation. Injectable gellan gum (GG) hydrogels, reduced by physical crosslinking methods, also being proposed as DDS, but this kind of crosslinking can produce hydrogels that become weaker in physiological conditions. Nevertheless, enzymatic crosslinking emerged as an alternative to increase mechanical strength, which can be adjusted by the degree of enzymatic crosslinking. In this study, tyramine-modified gellan gum (Ty-GG) hydrogels were developed via horseradish peroxidase (HRP) crosslinking; and betamethasone was encapsulated within, to increase the specificity and safety in the treatment of patients with RA. Physicochemical results showed that it was possible to modify GG with tyramine, with a degree of substitution of approximately 30%. They showed high mechanical strength and resistance, presenting a controlled betamethasone release profile over time. Ty-GG hydrogels also exhibited no cytotoxic effects and do not negatively affected the metabolic activity and proliferation of chondrogenic primary cells. Furthermore, the main goal was achieved since betamethasone-loaded Ty-GG hydrogels demonstrated to have a more effective therapeutic effect when compared with the administration of betamethasone alone. Therefore, the developed Ty-GG hydrogels represent a promising DDS and a reliable alternative to traditional treatments in patients with RA.

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Section: Physicochemical Propertiesmentioning

confidence: 99%

Section: Physicochemical Propertiesmentioning

confidence: 99%

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Enzymatically crosslinked tyramine-gellan gum hydrogels as drug delivery system for rheumatoid arthritis treatment

Oliveira

Gonçalves

Shin

et al. 2020

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

show abstract

“…These bonds are less flexible, so the capability of the polymer to retain the solvent is decreased by the physical crosslinking. The combination of both crosslinking mechanisms leads to obtaining hydrogels that significantly decrease their mass swelling ratio in PBS [ 36 , 37 ]. The results are in agreement with the studies previously mentioned, which showed that if an external solution is ionically more concentrated than structure, it will promote the entry of ions into the hydrogels, and water molecule expulsion.…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Properties of Injectable Betamethasone-Loaded Tyramine-Modified Gellan Gum/Silk Fibroin Hydrogels

et al. 2020

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Rheumatoid arthritis is a rheumatic disease for which a healing treatment does not presently exist. Silk fibroin has been extensively studied for use in drug delivery systems due to its uniqueness, versatility and strong clinical track record in medicine. However, in general, natural polymeric materials are not mechanically stable enough, and have high rates of biodegradation. Thus, synthetic materials such as gellan gum can be used to produce composite structures with biological signals to promote tissue-specific interactions while providing the desired mechanical properties. In this work, we aimed to produce hydrogels of tyramine-modified gellan gum with silk fibroin (Ty–GG/SF) via horseradish peroxidase (HRP), with encapsulated betamethasone, to improve the biocompatibility and mechanical properties, and further increase therapeutic efficacy to treat rheumatoid arthritis (RA). The Ty–GG/SF hydrogels presented a β-sheet secondary structure, with gelation time around 2–5 min, good resistance to enzymatic degradation, a suitable injectability profile, viscoelastic capacity with a significant solid component and a betamethasone-controlled release profile over time. In vitro studies showed that Ty–GG/SF hydrogels did not produce a deleterious effect on cellular metabolic activity, morphology or proliferation. Furthermore, Ty–GG/SF hydrogels with encapsulated betamethasone revealed greater therapeutic efficacy than the drug applied alone. Therefore, this strategy can provide an improvement in therapeutic efficacy when compared to the traditional use of drugs for the treatment of rheumatoid arthritis.

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“…In addition to simplicity, it affords hydrogels with pH-and thermo-sensitive behaviors which can be useful candidates for biomedical applications. While detailed reviews have been published about self-healing hydrogels, [27][28][29][30] the borax-based self-healing hydrogels, to the best of our knowledge, have been seldom reviewed.…”

Section: Introductionmentioning

confidence: 99%

Self‐healing Polyol/Borax Hydrogels: Fabrications, Properties and Applications

Seidi

Jin

Han

et al. 2020

The Chemical Record

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Self-healing polyol/borax hydrogels have found great applications in various areas; especially in sensors, flexible electronics and biomedical fields. In this review, fabrication and characteristics of various types of borax-based hydrogels are discussed. Mechanical properties and self-healing behaviors of these hydrogels are strongly affected by the types of polyol, ratio of polyol:borax, and concentration of each component. Incorporation of highly polar nanofillers (such as cellulose nanofibers) into hydrogels and fabrication of double-network structures have been employed as the promising strategies for improving the mechanical properties. Other additives have also been examined to generate nanocomposite hydrogels for a wide variety of uses; e. g. polyphenols for developing adhesives, conducting polymers, and hybrid structures based on carbon nanotubes and graphenes for electroconductivity, Ag and ZnO nanoparticles for antibacterial property, and quantum dots for fluorescence.

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Injectable and Self-Healing Chitosan Hydrogel Based on Imine Bonds: Design and Therapeutic Applications

Cited by 121 publications

References 51 publications

Enzymatically crosslinked tyramine-gellan gum hydrogels as drug delivery system for rheumatoid arthritis treatment

Enzymatically crosslinked tyramine-gellan gum hydrogels as drug delivery system for rheumatoid arthritis treatment

Anti-Inflammatory Properties of Injectable Betamethasone-Loaded Tyramine-Modified Gellan Gum/Silk Fibroin Hydrogels

Self‐healing Polyol/Borax Hydrogels: Fabrications, Properties and Applications

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