Tissue injuries of wistar rats treated with hydroalcoholic extract of Sonchus oleraceus L.

Abstract

The use of plant species is emerging as an important alternative in the treatment of injuries. Therefore, the extract of Sonchus oleraceus 10% was employed in the repair of skin lesions. A total of 36 male Wistar rats were subjected to a punch injury and divided into three groups: a negative control, receiving no treatment, a positive control, treated with Dersani, and the experimental group treated with the extract. The injury was assessed macroscopically and microscopically. Morphometric data was collected at the 3rd, 5th and 7th postoperative day, and the experimental group showed greater changes in shrinkage of the lesion compared to control groups. On the 3rd postoperative day, the injury in the experimental group showed less necrotic tissue, lower slough and more granulation tissue in relation to the positive control group. On the 7th and 10th postoperative day, the injury in the experimental group showed lower slough compared to the positive control group. Microscopic analysis of lesions on the 5th postoperative day revealed increased fibroplasia in the experimental group compared to control groups, while on the 14th postoperative day less neovascularization was evident in the experimental group and increased formation of hair follicles in the negative control group. The extract of S. oleraceus provided tissue repair in accordance with normal physiological patterns thus confirming empirical evidence for its use.

Hydroethanolic Allium sativum extract accelerates excision wound healing: evidence for roles of mast-cell infiltration and intracytoplasmic carbohydrate ratio

“…The filtrate was then shaken at room temperature for 24 h. The resulting extract was oven-dried at 40 ºC for 24 h, yielding 12 g of dry extract. The extracts were stored at -20 °C until use in the experiment (Abad, Nouri, Tavakkoli, 2011;Prichoa, Roman, Manfredini, 2011).…”

“…Specimens were fixed in 10% buffered formalin, processed, paraffinembedded, cut with a rotary microtome (5-µm slices), and stained for different purposes, as described below (Mashreghi et al, 2013;Süntar et al, 2012;Prichoa, Roman, Manfredini, 2011;Farahpour et al, 2015).…”

Obesidade Na Gravidez E Complicações Associadas: Revisão Integrativa

“…oleraceus (Nonato et al, 2015;Nonato et al, 2018). Prichoa (2011) identificou a ação cicatrizante por meio de estudos feitos com extrato hidroalcóolico de Sonchus oleraceus a 10% na reparação de feridas em ratos. Semelhante a esse resultado, Nonato (2014) mostrou eficácia com extrato hidroalcóolico de S. oleraceus L. a 15% também na reparação de feridas experimentais em ratos.…”

Oral Use of an Infusion of Leaves of <i>Solanum paniculatum</i> L., </i>Jacaranda brasiliensis</i> and </i>Sonchus oleraceus</i> for Treatment of Vitiligo

“…Postoperative showed big difference and speed healing by comparing the groups using and groups who did not use the product. Because of the ability to fight free radicals, characteristic of some of the compounds present in the extract of this plant, diseases that have the action of free radicals as cause, such as vitiligo, could be treated with this plant [20].…”