Tissue Factor, Tissue Factor Pathway Inhibitor and Factor VII Activity in Cardiovascular Complicated Type 2 Diabetes Mellitus

Elhagracy, Rehab S; Kamal, Gihan M.; Sabry, Inas Mohamed; Saad, Abeer A.; Ezz, Nahla F. Abou El; Nasr, H

doi:10.5001/omj.2010.52

Cited by 22 publications

(29 citation statements)

References 42 publications

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“…The studies by Chu et al (2011) and El-Hagracy et al (2010) and the current study confirmed the role of TF in microvascular diabetic complications. However, the results revealed an endothelial dysfunction instead of the procoagulant state.…”

Section: Discussionsupporting

confidence: 66%

“…It was observed that TF could dependently be associated with age and independently with triglycerides and total cholesterol. An increased TF level with age was observed by El-Hagracy et al (2010), which confirms a higher risk of the hypercoagulable state or endothelium damage with age. However, an inverse relationship between TF and triglycerides and total cholesterol is problematic to explain on the basis of the present results, perhaps the patients' treatment might have had a strong influence on the outcomes.…”

Section: Discussionsupporting

confidence: 58%

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Low-grade risk of hypercoagulable state in patients suffering from diabetes mellitus type 2

Ruszkowska-Ciastek

Sokup

Wernik

et al. 2015

J. Zhejiang Univ. Sci. B

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Abstract:Objective: Diabetes, including type 1 and type 2, is associated with the hypercoagulable state. The aim of this study is to evaluate the concentration of selected hemostatic parameters and vascular endothelial growth factor-A (VEGF-A) in diabetic subjects. Methods: The study was conducted in 62 patients with diabetes. Group I consisted of 27 patients having uncontrolled diabetes with microalbuminuria and Group II included 35 well-controlled diabetic patients. The control group was made up of 25 healthy volunteers. In the citrate plasma, the concentrations of tissue factor (TF), tissue factor pathway inhibitor (TFPI), thrombin-antithrombin (TAT) complexes, and D-dimer were assayed. Serum concentrations of VEGF-A, lipid profile, creatinine, and plasma fasting glucose were measured and in the versene plasma the concentration of HbA1c was determined. Results: In the patients with uncontrolled diabetes, higher concentrations of TF, TFPI, and VEGF-A were observed, as compared with the well-controlled diabetics group and the control group. A significantly lower activity of antiplasmin was reported in patients from Group I as compared with the control group. In Group I, using the multivariate regression analysis, the glomerular filtration rate was independently associated with VEGF-A and dependently associated with total cholesterol. Conclusions: The study showed higher concentrations of TF and TFPI in the patients with uncontrolled diabetes with microalbuminuria, which is associated with rapid neutralization of the thrombin formation, since TFPI inhibits the complex of TF/VIIa/Ca 2+ . The manifestation of the above suggestions is the correct TAT complexes and D-dimer, which indicates a low grade of prothrombotic risk in this group of patients, but a higher risk of vascular complications.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionsupporting

confidence: 58%

Low-grade risk of hypercoagulable state in patients suffering from diabetes mellitus type 2

Ruszkowska-Ciastek

Sokup

Wernik

et al. 2015

J. Zhejiang Univ. Sci. B

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“…This observation is consistent with the studies of Ay et al [10] and Darvall et al [11], which may indicate the activation of the coagulation system, leading to an increase in thrombin generation. El-Hagracy et al presented a positive correlation between TF and BMI, elevating thrombotic tendency [12].…”

Section: Discussionmentioning

confidence: 97%

“…Lipids have a strong affinity for binding TFPI. Lipoprotein-associated TFPI presents fewer anticoagulant properties than free TFPI [12,17]. On the other hand, an increase in the expression of pro-inflammatory adipocytokines stimulates the release of TF-PI [17].…”

Section: Discussionmentioning

confidence: 99%

Effect of a 3-Week Low-Calorie Diet and Balneological Treatment on Selected Coagulation Parameters in Morbidly Obese Patients

et al. 2016

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is greater than energy expenditure, causing both the hyperplasia and the hypertrophy of adipocytes. Adipocyte hypertrophy has negative consequences connected with insulin resistance and chronAccording to the World Health Organization (WHO), obesity is related to an excessive accumulation of adipose tissue, which may result in health deterioration [1]. This occurs when energy input AbstractBackground. The most common cause of death among people with obesity are cardiovascular complications as a result of a hypercoagulability state. Objectives. The purpose of the study was to assess the potential of coagulation system activation depending on the tissue factor and to analyze of the influence of a 3-week low-calorie diet and balneological treatment on selected coagulation parameters in morbidly obese patients. Material and Methods. The study included 36 patients (28 females and 8 males; mean age 46) with the value of BMI > 40 kg/m 2 . The study was designed in two stages: baseline and after 21-days. The evaluation of tissue factor (TF), tissue factor pathway inhibitor (TFPI), von Willebrand factor (vWF), fibrinogen, D-dimer, thrombin--antithrombin complexes (TAT), and the activity of antithrombin (AT) was performed in patients before and after the treatment. The control group consisted of 24 healthy volunteers (16 females and 8 males) at a mean age of 39 with BMI ≤ 24.9 kg/m 2 . Results. There were significantly higher levels of TF, TFPI, fibrinogen, TAT complexes and D-dimer in the study group as compared to the controls. Moreover, there were no significant changes in the parameters studied before and after the treatment. In the group of obese patients, there were significant positive correlations between the concentrations of vWF and BMI and BMI changes and a significant negative correlation between the WHR changes and TFPI concentration. Conclusions. The study confirmed that morbidly obese patients represent a high risk of hypercoagulability state, despite no clinical evidence, which could be due to the great inhibitory potential of TFPI in suppressing the extrinsic pathway of the coagulation system. However, the lack of effect of the 3-week exposure to the LCD and balneological treatment in morbidly obese subjects indicates that substantial fat mass must be reduced before adequate hemostasis is re-established (Adv Clin Exp Med 2016, 25, 4, 755-761).

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“…be the result of endothelial damage or increased procoagulant activity of TF. 15 The analysis of TFPI depending on the JAK2 V617F mutation revealed differences in the activity of TFPI between the subgroups with and without the mutation. We found a significantly reduced TFPI activity in patients with ET with the JAK2 V617F mutation, compared with patients without the mutation.…”

Section: Abbreviations: Ns Nonsignificantmentioning

confidence: 99%

Extrinsic blood coagulation pathway and risk factors for thrombotic events in patients with essential thrombocythemia

Stankowska¹,

Gadomska²,

Boińska³

et al. 2016

Polish Archives of Internal Medicine

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IntroductIon The clinical course of essential thrombocythemia (ET) is varied, and some patients do not exhibit any clinical signs of the disease at the time of diagnosis. The most frequent complications that occur during the course of ET are hemostasis abnormalities manifesting as hemorrhagic or thrombotic events. The mechanism of thrombotic events in patients with ET is complex and not fully understood.objectIves The aim of the study was to evaluate the concentration and activity of tissue factor (TF) and tissue factor pathway inhibitor (TFPI), depending on the most important risk factors of thrombotic complications (age >60 years, history of thrombotic episodes, presence or absence of the JAK2 V617F mutation, and increased leukocyte count).PAtIents And methods The study group included 113 patients with diagnosed ET, and the control group, 30 healthy volunteers matched for age and sex. The concentration and activity of TF and TFPI were measured using enzyme-linked immunosorbent assays.results Patients with ET had a significantly higher activity and concentration of TF and increased activity of TFPI, as compared with controls. The analysis of the studied parameters in relation to risk factors revealed that patients with ET with a history of thrombotic events had a significantly higher concentration of TF, and patients with the JAK2 V617F mutation had a lower TFPI activity, as compared with patients without the mutation.conclusIons Our study showed that in patients with ET who have a history of thrombosis or the JAK2 V617F mutation, the enhanced risk of thrombosis may result from an increased TF concentration or decreased TFPI activity.

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Tissue Factor, Tissue Factor Pathway Inhibitor and Factor VII Activity in Cardiovascular Complicated Type 2 Diabetes Mellitus

Cited by 22 publications

References 42 publications

Low-grade risk of hypercoagulable state in patients suffering from diabetes mellitus type 2

Low-grade risk of hypercoagulable state in patients suffering from diabetes mellitus type 2

Effect of a 3-Week Low-Calorie Diet and Balneological Treatment on Selected Coagulation Parameters in Morbidly Obese Patients

Extrinsic blood coagulation pathway and risk factors for thrombotic events in patients with essential thrombocythemia

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