Low-grade risk of hypercoagulable state in patients suffering from diabetes mellitus type 2

Ruszkowska-Ciastek, Barbara; Sokup, Alina; Wernik, Tomasz; Rhone, Piotr; Góralczyk, Krzysztof; Bielawski, Kornel; Fijałkowska, Agata; Nowakowska, Aleksandra; Rhone, Elżbieta; Rość, Danuta

doi:10.1631/jzus.b1500066

Cited by 9 publications

(8 citation statements)

References 25 publications

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“…The finding in our study of elevated TF levels in both diabetic groups, compares favourably with other studies where high TF levels are found in type 2 diabetic subjects (El-Hagracy et al, 2010, Ruszkowska-Ciastek et al, 2015, Boden et al, 2007. We additionally show that cardiovascular complications in diabetes further increase TF levels.…”

Section: Discussionsupporting

confidence: 86%

Tissue factor levels in type 2 diabetes mellitus

et al. 2017

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Section: Discussionsupporting

confidence: 86%

Tissue factor levels in type 2 diabetes mellitus

et al. 2017

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“…VEGF is an angiogenic protein which contributes to the angiogenesis and endothelial cell proliferation . Serum VEGF‐A levels were significantly higher in uncontrolled type 2 DM group than in well‐controlled DM group and healthy volunteers . Kubisz et al reported serum VEGF could be a sensitive predictor of endothelial dysfunction in type 2 DM.…”

Section: Discussionmentioning

confidence: 99%

Expression of Natural Cytotoxicity Receptors on and Intracellular Cytokine Production by NK Cells in Women with Gestational Diabetes Mellitus

Chiba

Fukui

Fuchinoue

et al. 2016

American J Rep Immunol

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Gestational diabetes mellitus (GDM) is characterized by glucose intolerance that is caused by metabolic changes during pregnancy, and is considered a risk factor for the occurrence of DM in future. There are studies that reported changes in the cytokine in women with GDM. The concentration of serum IFN-γ and adiponectin decreased, while serum leptin, IL-6, IL-10, and TNF-α increased in GDM women when compared to that in healthy pregnant women. 16 17 Placenta and adipose tissues from patients with GDM released higher amounts of TNF-α in response to high glucose than that from normal pregnant women.18 Plasma TNF-α were reported to be low during the first and second trimester, but it increased during late pregnancy, and was inversely correlated with the insulin sensitivity. 19, 20 However, the relationship between GDM and the functions of NK cells in pregnant women has not been clarified so far. The purpose of this study was to evaluate the expression of peripheral blood NK (pNK) cell surface markers (CD16, NKp46, and NKp30) and the percentage of cytokine (IFN-γ, TNF-α, TGF-β, and VEGF) producing pNK cells in women with / without GDM at 12 weeks of pregnancy. 2 Materials and Methods Study SubjectsWe designed a prospective study and patients from Hirosaki University Hospital were recruited for this study between July 2014 and March 2015. This study was approved by the local ethics committee, and signed informed consent forms were obtained from all study subjects. Blood samples were collected during routine blood tests for prenatal check-up at 12weeks of gestation.Thirty-four Japanese women (GDM (n=7), non-GDM (n=27)) with singleton pregnancy were included. All GDM patients were diagnosed at 12 to 16 weeks of gestation. Pregnant women with multi-fetal gestations, pre-gestational diabetes, and overt diabetes were excluded, while pregnant women with impaired glucose tolerance before the onset of pregnancy were included in this study. Maternal and neonatal characteristics are shown in Table 1. Two-hour-glucose level of 75-g OGTT in GDM group was significantly higher than that in the non-GDM group.There were no complications reported in the newborn infants (such as macrosomia, shoulder dystocia, and hypoglycemia) in both the GDM and non-GDM groups and there were no pregnant women suffering from PE in both the GDM and non-GDM groups. Screening of GDMAll pregnant women were subjected to a two-step screening method for GDM. This screening method is based on the Guideline for Obstetrical Practice in Japan 2014. 21 Briefly, women who had a random plasma glucose level of ≥95mg/dl at 12 weeks of gestation were subjected to 75-g OGTT after fasting overnight. Diagnosis of GDM was based on the criteria of one or more abnormal values [fasting ≥92mg/dl (5.1mmol/l), such as 1 hour ≥180mg/dl (10.0mmol/l) or 2 hour ≥153mg / dl (8.5mmol/l)] reported for the subjects. Pregnant women, not diagnosed as GDM at 12 weeks of screening, were again subjected to random blood glucose measurement at 3 28 weeks of gestation. Women with random...

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“…It has been recognized that many biomarkers play potential roles in diagnosis and prognosis of diabetic nephropathy [ 11 ]. Moreover, patients with diabetes could show hypercoagulability and high levels of coagulation factors [ 12 ], and diabetes mellitus, including type 1 and type 2, is associated with the hypercoagulable state through increased thrombotic tendencies [ 13 ], even exhibiting prothrombotic milieu which is due to upregulation of coagulation factors and prolongation of clot lysis [ 14 ]. Increased concentration of coagulation factors is widely reported in type 2 diabetes mellitus [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance of Hemostatic Parameters in the Prediction for Type 2 Diabetes Mellitus and Diabetic Nephropathy

Pan¹,

et al. 2018

Disease Markers

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It would be important to predict type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN). This study was aimed at evaluating the predicting significance of hemostatic parameters for T2DM and DN. Plasma coagulation and hematologic parameters before treatment were measured in 297 T2DM patients. The risk factors and their predicting power were evaluated. T2DM patients without complications exhibited significantly different activated partial thromboplastin time (aPTT), platelet (PLT), and D-dimer (D-D) levels compared with controls (P < 0.01). Fibrinogen (FIB), PLT, and D-D increased in DN patients compared with those without complications (P < 0.001). Both aPTT and PLT were the independent risk factors for T2DM (OR: 1.320 and 1.211, P < 0.01, resp.), and FIB and PLT were the independent risk factors for DN (OR: 1.611 and 1.194, P < 0.01, resp.). The area under ROC curve (AUC) of aPTT and PLT was 0.592 and 0.647, respectively, with low sensitivity in predicting T2DM. AUC of FIB was 0.874 with high sensitivity (85%) and specificity (76%) for DN, and that of PLT was 0.564, with sensitivity (60%) and specificity (89%) based on the cutoff values of 3.15 g/L and 245 × 109/L, respectively. This study suggests that hemostatic parameters have a low predicting value for T2DM, whereas fibrinogen is a powerful predictor for DN.

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Low-grade risk of hypercoagulable state in patients suffering from diabetes mellitus type 2

Cited by 9 publications

References 25 publications

Tissue factor levels in type 2 diabetes mellitus

Tissue factor levels in type 2 diabetes mellitus

Expression of Natural Cytotoxicity Receptors on and Intracellular Cytokine Production by NK Cells in Women with Gestational Diabetes Mellitus

Clinical Significance of Hemostatic Parameters in the Prediction for Type 2 Diabetes Mellitus and Diabetic Nephropathy

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