Tissue eosinophilia: A valuable marker in assessing stromal invasion, locoregional recurrence &amp; distant metastasis in head &amp; neck squamous cell carcinomas

Alrawi, Sadir; Tan, Dongfeng; Douglas, Wade G.; Hicks, Wesley L.; Loree, Thom R.; Rigual, Néstor R.

doi:10.1007/bf02524010

Cited by 20 publications

(45 citation statements)

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“…In other words, these are gallbladder counterparts of pancreatic intraductal papillary mucinous neoplasms, 1 biliary intraductal papillary neoplasms, 1 and intraampullary papillary tubular neoplasms. 1,[38][39][40][41] In addition, both the study group and a control group (composed of 50 cases randomly selected from the excluded cases without any squamous differentiation) were analyzed for the following parameters: histological grade (well, moderate or poor, as determined by conventional approach), vascular invasion, perineural invasion, tumor giant cells and the amount of 'tumor-infiltrating' inflammatory cells (eosinophils and lymphocytes) as defined in other studies; [42][43][44] ie, those associated preferentially with the tumor (in the vicinity of the tumor, in between the tumor cells or immediately adjacent to tumor cell clusters). The inflammation was semiquantitatively scored as 0 ¼ none, 1 ¼ minimal, 2 ¼ moderate and 3 ¼ marked, and subsequently grouped for comparison purposes as negligible (0 and 1) and significant (2 and 3).…”

Section: Histopathological Analysismentioning

confidence: 99%

Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas

et al. 2011

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The information in the literature on squamous cell and adenosquamous carcinomas of the gallbladder is highly limited. In this study, 606 resected invasive gallbladder carcinoma cases were analyzed. Squamous differentiation was identified in 41 cases (7%). Those without any identifiable glandular-type invasive component were classified as pure squamous cell carcinomas (8 cases) and those with the squamous component constituting 25-99% of the tumors were classified as adenosquamous carcinomas (26 cases) and included into the analysis. The remaining 7 that had o25% squamous component were classified as adenocarcinoma with focal squamous change and excluded. The clinicopathological characteristics of adenosquamous carcinoma/squamous cell carcinomas were documented and contrasted with that of ordinary gallbladder adenocarcinomas. The average patient age was 65 years (range 26-81); female/male ratio, 3.8. In only 13%, there was a preoperative clinical suspicion of malignancy. Grossly, 58% presented as thickening and hardening of the wall and 6% were polypoid. In 12%, mucosa adjacent to the tumor revealed squamous metaplasia. All pure squamous cell carcinomas had prominent keratinization. Giant cells and tumor-infiltrating eosinophils were observed in 29 and 51% of the squamous cell carcinomas/adenosquamous carcinomas versus 10% (P ¼ 0.02) and 6% (P ¼ 0.001) in gallbladder adenocarcinomas, respectively. All but three cases had 'advanced' (pT2 and above) carcinomas. Follow-up was available in 31 patients: 25 died of disease (median ¼ 5 months, range 0-20), and 6 were alive (median ¼ 64 months, range 5-112.5). The survival of patients with squamous cell carcinomas/adenosquamous carcinomas was significantly worse than that of gallbladder adenocarcinomas (P ¼ 0.003), and this adverse prognosis persisted when compared with stage-matched advanced gallbladder adenocarcinoma cases (median ¼ 11.4 months, P ¼ 0.01). In conclusion, squamous differentiation was noted in 7% of gallbladder carcinomas. The incidence of adenosquamous carcinoma (defined as 25-99% of the tumor being squamous) was 4%, and that of pure squamous cell carcinoma (without any documented invasive glandular component) was 1%. Pure squamous cell carcinomas often showed prominent keratinization. The overall prognosis of adenosquamous carcinoma/squamous cell carcinoma appears to be even worse than that of ordinary adenocarcinomas. Most patients died within a few months; however, those few who were alive beyond 2 years in this cohort experienced long-term survival.

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Section: Histopathological Analysismentioning

confidence: 99%

Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas

et al. 2011

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“…[12] Similarly, Alrawi et al established amplified eosinophil number in aggressive tumor compared to noninvasive tumors of head and neck region. [13] Hence, TATE shows dual nature of tumor promoting and tumor inhibiting activity.…”

Section: Eosinophils In Diseases Role Of Eosinophils In Precancer Andmentioning

confidence: 99%

Eosinophils in health and diseases

Mumtaz¹,

Hegde²,

Khan³

2016

JMRPS

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Eosinophils are multifunctional cells whose activities are associated with a single gene and have a diverse role in inflammation as well as in immunity (both innate and adaptive). Our understanding of this multifunctional leukocyte over the past two decades has enhanced from a definitely damaging cell to a cell actively participating in many physiological and pathological processes. Eosinophils are different from other granulocytes by their dense population of cytoplasmic crystalloid granules also known as secretory granules. These secretory granules contain full-bodied stores of various preformed cationic proteins. Numerous functions of eosinophils have been identified over the years, and there capabilities to synthesize, accumulate, and express a varied range of cytokines. The machineries leading to selective formation of preformed cytokines are especially beneficial targets when treatment is concerned. The present review discusses the recent and upcoming notion about the complexities in the structure of human eosinophils and also discusses its role in health and diseases, especially in precancer and cancer. Furthermore, an update on our knowledge of various stains and markers has been discussed in this review.

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“…Некоторые авторы отмечают наличие связи тканевой эозинофилии с благопри-ятным прогнозом заболевания и увеличе-нием 5-летней выживаемости пациентов с опухолевой патологией [2,3]. Вместе с тем, в литературе есть сведения о способ-ности эозинофилов обеспечивать процесс ремоделирования тканей и, напротив, со-действовать развитию и прогрессированию опухоли [4,5].…”

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Molecular genetic and morphological features of malignant neoplasms of the stomach and colon with tissue eosinophilia

et al. 2017

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Aim. To study molecular genetic and morphological features of neoplasms in stomach and colon cancer associated with tissue eosinophilia. Methods. Study material was the tissue samples of malignant neoplasms of the stomach and colon obtained from the surgical procedures. Study groups were identified depending on the presence or absence of eosinophilic infiltration of the tumour tissue as well as on neoplasm localization. Medical records and outpatient patient cards were analyzed, presence of matastases in regional lymph nodes and grade of differentiation of malignant cells were evaluated. In tumour tissue expression of p53 and p21 proteins was evaluated by means of immunohistochemical technique. To study the distribution of polymorphic variants of р53 (G215C) and р21 (A1026G) genes, deoxyribonucleic acid extraction was performed from formalin-fixed and paraffin-embedded tissue samples obtained from the resection margins. Polymorphism genotyping of deoxyribonucleic acid samples was performed by restriction fragment length polymorphism analysis of amplification products with the use of polymerase chain reaction of specific genome regions with further visualization with ultraviolet light. Results. In patients with colon cancer associated with tissue eosinophilia tumour cells were shown to have higher grade of differentiation than in patients without eosinophilia. In stomach cancer associated with eosinophilic infiltration low expression of mutant p53 protein was revealed significantly more frequently as opposed to cancer without eosinophilia. Also in patients with stomach and colon cancer, association of tissue eosinophilia with carriage of G allele of р53 (G215C) gene polymorphism was found. Conclusion. Tissue eosinophilia in stomach and colon cancer is associated with favourable morphological cancer characteristics, low expression of mutant p53 protein and carriage of G allele of р53 (G215C) polymorphism.

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Tissue eosinophilia: A valuable marker in assessing stromal invasion, locoregional recurrence & distant metastasis in head & neck squamous cell carcinomas

Cited by 20 publications

References 0 publications

Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas

Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas

Eosinophils in health and diseases

Molecular genetic and morphological features of malignant neoplasms of the stomach and colon with tissue eosinophilia

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