Tissue eosinophilia: a morphologic marker for assessing stromal invasion in laryngeal squamous neoplasms

Said, Mohamed M.; Wiseman, Sam M.; Yang, Jun; Alrawi, Sadir; Douglas, Wade G.; Cheney, Richard; Hicks, Wesley L.; Rigual, Néstor R.; Loree, Thom R.; Spiegel, Gregory; Tan, Dongfeng

doi:10.1186/1472-6890-5-1

Cited by 37 publications

(45 citation statements)

References 14 publications

(10 reference statements)

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“…The mechanisms underlying eosinophilic accumulation in invasive SCC are not fully known [9]. It was suggested that lesion-derived eosinophil chemotactic factors induce eosinophilic infiltration.…”

Section: Discussionmentioning

confidence: 99%

“…Agarwal et al [8] reported findings similar to those of Spiegel et al and suggested that the presence of stromal eosinophils should result in a search for invasion in deeper sections in lesions of cervical intraepithelial neoplasia II and III Alrawi et al [2] reported higher eosinophilic counts in laryngeal SCC lesions than in SCCIS, concluding that tissue eosinophilia might be a pathological feature associated with stromal invasion. Similarly, Said et al [9] reported that an elevated eosinophil count in squamous neoplasia of the larynx is associated with stromal invasion, and recommended a thorough search for invasion when the number of infiltrating eosinophils is > 10 eosinophils HPF-1 and/or 20 eosinophils 10 HPFs-1. More recently, Jain et al [1] observed higher eosinophil counts in oral SCC than those in oral dysplasia, suggesting they play a role in stromal invasion.…”

Section: Discussionmentioning

confidence: 99%

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Tissue eosinophilia: a histopathological marker associated with stromal invasion but not histopathological grade in cutaneous squamous neoplasia

2015

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Tumor-associated tissue eosinophilia was first described in 1896 in cervical carcinoma and is defined as eosinophilic infiltration in a tumor that is not associated with necrosis or ulceration. Its functional role remains unclear [1]. Eosinophilic infiltration has been reported in carcinomas located in the oral cavity, larynx, pharynx, gastrointestinal tract, lungs, cervix, and external genitalia; however, the literature includes limited data on eosinophilic infiltration in cutaneous squamous cell carcinoma (SCC) [1,2].Objectives. The literature does not include any comparative study on the eosinophil count in premalignant and malignant cutaneous squamous neoplasias. Our aim was to compare the tissue eosinophilic count in actinic keratosis (AK) and cutaneous squamous cell carcinoma (SCC). Methods. The study included 20 AK and 20 invasive SCC patients. Age, gender, and lesion location were retrospectively evaluated as clinical parameters. Histopathological parameters included density of inflammation score, lesion grade, and the lesion-associated eosinophil count per 10 high-power (40×) microscopic fields, all of which were compared between groups. Results. In all, 65% of the AK group had lesions with moderate inflammation, whereas 85% of the SCC group had lesions with dense inflammation (p=0.001). The mean eosinophil count in the SCC group was significantly higher than that in the AK group, independent of the density of inflammation (p=0.000). In addition, lesion grade was not associated with the eosinophil count in either group (AK group: p=0.601; SCC group: p=0.416). Conclusions. Cutaneous SCC lesions had higher eosinophil counts than AK lesions, indicating the role of the eosinophil count as a histopathological marker of stromal invasion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Tissue eosinophilia: a histopathological marker associated with stromal invasion but not histopathological grade in cutaneous squamous neoplasia

2015

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“…Infiltrados de eosinófilos foram observados anteriormente em CCEs do TAS de bovinos intoxicados por samambaia (Polack 1990), porém sua presença não foi discutida. Eosinófilos têm sido constantemente observados em CCEs de laringe em humanos (Ercan et al 2005, Said et al 2005) e foram correlacionados com um maior potencial de invasão tumoral (Said et al 2005) ou com a idade dos pacientes, sendo mais freqüentes em pessoas acima de 60 anos (Ercan et al 2005). O papel dos eosinófilos nos CCEs de bovinos intoxicados por samambaia não está definido e poderá vir a ser investigado.…”

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Neoplasias do trato alimentar superior de bovinos associadas ao consumo espontâneo de samambaia (Pteridium aquilinum)

et al. 2006

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Foram estudados 30 bovinos com neoplasias no trato alimentar superior (TAS) associadas ao consumo espontâneo de samambaia (Pteridium aquilinum) provenientes de 27 propriedades rurais, sendo 23 no município de Jaguari e quatro em Nova Esperança do Sul, Rio Grande do Sul. A população bovina total das 27 propriedades em que ocorreram os casos era de 1.090 bovinos e havia quantidade abundante de samambaia nas áreas de pastoreio dos animais. Vinte e seis bovinos eram vacas e 4 eram machos castrados. A idade variou de 3 a 13 anos, sendo o maior número de casos entre 7 e 8 anos (46,6%). Os sinais clínicos observados incluíram emagrecimento progressivo, atonia ruminal, tosse, disfagia, regurgitação, halitose, diarréia e timpanismo. Outros sinais clínicos menos freqüentes foram apetite seletivo, dispnéia e salivação. Dois bovinos tiveram morte espontânea e 28 foram submetidos à eutanásia em estágios avançados da doença e necropsiados. Os principais achados macroscópicos e histológicos observados nos 30 bovinos localizavam-se nos mesmos locais do TAS e consistiram de papilomas, papilomas em transformação para carcinomas de células escamosas (CCEs) e CCEs. Metástases de CCEs para linfonodos regionais e outros órgãos (como fígado e pulmões) foram também observadas (18/30). Vinte e nove bovinos tinham papilomas de diversos tamanhos, sendo a quantidade variável entre leve (45%), moderada (38%) e acentuada (17%). Nos papilomas examinados microscopicamente, foram observadas três fases de desenvolvimento: a) fase de inicial de crescimento, b) fase de desenvolvimento, e c) fase de regressão. Em 16 bovinos, observou-se a transformação maligna de papilomas em CCEs. Os CCEs eram únicos (12/30) ou múltiplos (18/30) e variaram quanto ao grau de diferenciação celular entre bem, moderadamente ou pouco diferenciados. Quando a distribuição dos CCEs de maior extensão foi agrupada em regiões cranial (base da língua, faringe/orofaringe, epiglote), média (terços cranial, médio e caudal do esôfago) e caudal (entrada do rúmen e rúmen) do TAS, observou-se que a localização era cranial em 39% dos casos, média em 16%, e caudal em 45%. Utilizando-se esse mesmo critério de agrupamento, porém considerando o número total de vezes em que CCEs (de tamanhos variados) foram diagnosticados nas regiões cranial, média e caudal, os números alteraram-se para 34, 26 e 40%, respectivamente. As evidências epidemiológicas e histomorfológicas relatadas neste estudo reforçam as observações de uma estreita correlação entre a infecção pelo papiloma-vírus bovino tipo 4, causador da papilomatose digestiva, e a co-carcinogênese química dos princípios tóxicos da samambaia na patogênese dos CCEs do TAS de bovinos. Entretanto, a presença de alterações pré-neoplásicas (áreas de displasia), áreas de CCE in situ ou CCEs em estágios iniciais de desenvolvimento, independentemente da presença de papilomas no local, mostram claramente ser possível o desenvolvimento de CCEs diretamente do epitélio normal, possivelmente por uma ação direta dos carcinó-genos químicos da samambaia.

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“…Recently, eosinophilia has been investigated in head and neck carcinomas, especially the oral cavity carcinomas [7][8][9][10][11]. Although it has been shown that the relationship between eosinophil count and prognosis is statistically significant, it still remains controversial [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Tumor-Associated Tissue Eosinophilia as a Prognostic Factor in Squamous Cell Carcinoma of the Larynx

Etıt

Yardim

Arslanoğlu

et al. 2011

Indian J Otolaryngol Head Neck Surg

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Inflammatory infiltration with eosinophilia in or around the tumoral tissue varies among the cases with invasive squamous cell carcinoma of the larynx. The aim of this study was to investigate the possible role of the tumor-associated tissue eosinophilia (TATE) as a predictive factor for the metastatic status in laryngeal squamous cell carcinoma in patients who had neck dissections. One hundred consecutive specimens from the patients who had been treated surgically for invasive squamous cell carcinoma of the larynx were re-evaluated in terms of TATE.

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Tissue eosinophilia: a morphologic marker for assessing stromal invasion in laryngeal squamous neoplasms

Cited by 37 publications

References 14 publications

Tissue eosinophilia: a histopathological marker associated with stromal invasion but not histopathological grade in cutaneous squamous neoplasia

Tissue eosinophilia: a histopathological marker associated with stromal invasion but not histopathological grade in cutaneous squamous neoplasia

Neoplasias do trato alimentar superior de bovinos associadas ao consumo espontâneo de samambaia (Pteridium aquilinum)

Tumor-Associated Tissue Eosinophilia as a Prognostic Factor in Squamous Cell Carcinoma of the Larynx

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