Tissue Engineering Strategies for Myocardial Regeneration: Acellular Versus Cellular Scaffolds?

Domenech, Maribella; Polo-Corrales, Lilliana; Ramı́rez-Vick, Jaime E.; Freytes, Donald O.

doi:10.1089/ten.teb.2015.0523

Cited by 87 publications

(72 citation statements)

References 184 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, sutures may cause tissue damage and hemorrhage, and glues may hinder cell migration from the patch to defected tissue . Natural polymer‐based cardiac patches (e.g., collagen, gelatin, and fibrin) usually have poor mechanical properties and fast degradation rate, which can inhibit long‐term therapeutic effects . Cell sheet transplantation is another important stem cell–based technique for treating myocardial infarction.…”

Section: Resultsmentioning

confidence: 99%

“…This scaffold‐free cell therapy has been widely applied to deliver diverse types of stem cells onto infarcted heart . However, cell death often occurs immediately after transplantation into ischemic myocardium with intensive inflammation and tissue necrosis, leading to graft failure . More critically, cell sheets do not possess high enough mechanical stability to withstand the contractile forces of a beating heart .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off‐the‐Shelf Therapy

Shin

Choi

Kim

et al. 2019

Adv Funct Materials

106

102

View full text Add to dashboard Cite

Hydrogels have been applied to improve stem cell therapy and drug delivery, but current hydrogel-based delivery methods are inefficient in clinical settings due to difficulty in handling and treatment processes, and low off-the-shelf availability. To overcome these limitations, an adhesive hyaluronic acid (HA) hydrogel patch is developed that acts as a ready-to-use tissue tape for therapeutic application. The HA hydrogel patches functionalized with phenolic moieties (e.g., catechol, pyrogallol) exhibit stronger tissue adhesiveness, greater elastic modulus, and increased off-the-shelf availability, compared with their bulk solution gel form. With this strategy, stem cells are efficiently engrafted onto beating ischemic hearts without injection, resulting in enhanced angiogenesis in ischemic regions and improving cardiac functions. HA hydrogel patches facilitate the in vivo engraftment of stem cell-derived organoids. The off-the-shelf availability of the hydrogel patch is also demonstrated as a drug-loaded ready-made tissue tape for topical drug delivery to promote wound healing. Importantly, the applicability of the cross-linker-free HA patch is validated for therapeutic cell and drug delivery. The study suggests that bioinspired phenolic adhesive hydrogel patches can provide an innovative method for simple but highly effective cell and drug delivery, increasing the off-the-shelf availability-a critically important component for translation to clinical settings.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off‐the‐Shelf Therapy

Shin

Choi

Kim

et al. 2019

Adv Funct Materials

106

102

View full text Add to dashboard Cite

show abstract

“…151 The ideal properties of these biomaterials include, but are not limited to, high porosity, high surface area-to-cell volume ratio, microenvironment similar to natural ECM, good mechanical properties, biodegradability, and biocompatibility. 152 Despite the tremendous advances in engineered cardiac tissue, the complete restoration of myocardial function remains elusive, and work needs to be done in order to potentiate the biological activity of these biomaterials to offer biophysical support to the damaged heart.…”

Section: Mscs For Cardiac Repair Preclinical Studiesmentioning

confidence: 99%

Mesenchymal Stem Cell-Based Therapy for Cardiovascular Disease: Progress and Challenges

et al. 2018

View full text Add to dashboard Cite

Administration of mesenchymal stem cells (MSCs) to diseased hearts improves cardiac function and reduces scar size. These effects occur via the stimulation of endogenous repair mechanisms, including regulation of immune responses, tissue perfusion, inhibition of fibrosis, and proliferation of resident cardiac cells, although rare events of transdifferentiation into cardiomyocytes and vascular components are also described in animal models. While these improvements demonstrate the potential of stem cell therapy, the goal of full cardiac recovery has yet to be realized in either preclinical or clinical studies. To reach this goal, novel cell-based therapeutic approaches are needed. Ongoing studies include cell combinations, incorporation of MSCs into biomaterials, or pre-conditioning or genetic manipulation of MSCs to boost their release of paracrine factors, such as exosomes, growth factors, microRNAs, etc. All of these approaches can augment therapeutic efficacy. Further study of the optimal route of administration, the correct dose, the best cell population(s), and timing for treatment are parameters that still need to be addressed in order to achieve the goal of complete cardiac regeneration. Despite significant progress, many challenges remain.

show abstract

“…Heart attack or myocardial infarction (MI) which is defined as myocardial cell death is caused by occlusion of a coronary artery. 1,2 As the mammalian heart has limited regenerative capacity, cardiac damage can lead to some critical pathological symptoms and even catastrophic heart failure. 3,4 Regeneration of the damaged heart tissue is the primary goal of myocardial tissue engineering (MTE).…”

Section: Introductionmentioning

confidence: 99%

Application of minimally invasive injectable conductive hydrogels as stimulating scaffolds for myocardial tissue engineering

Ketabat

Khorshidi

Karkhaneh

2018

Polymer International

View full text Add to dashboard Cite

So far, several methods for myocardial tissue engineering have been developed to regenerate myocardium and even create contractile heart muscles. Among these approaches, hydrogel based methods have attracted much attention due to their ability to mimic the architecture of native extracellular matrix. Injectable hydrogels are a specific class of hydrogels which can be formed in situ by physical and/or chemical crosslinking. Generally, using these hydrogels is more advantageous because they are minimally (less) invasive in comparison with open surgery. Moreover, with respect to the fact that ‘myocardium is a conductive tissue’, utilization of conductive polymers for myocardial tissue engineering has demonstrated promising results. Both the injectable hydrogels and conductive polymers have some merits and demerits, but studies show that using a combination of them has prominently enhanced regeneration of the myocardium. In this review, the focus is on injectable hydrogels, conductive polymers and injectable conductive hydrogels for myocardial tissue engineering. © 2018 Society of Chemical Industry

show abstract

Tissue Engineering Strategies for Myocardial Regeneration: Acellular Versus Cellular Scaffolds?

Cited by 87 publications

References 184 publications

Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off‐the‐Shelf Therapy

Tissue Tapes—Phenolic Hyaluronic Acid Hydrogel Patches for Off‐the‐Shelf Therapy

Mesenchymal Stem Cell-Based Therapy for Cardiovascular Disease: Progress and Challenges

Application of minimally invasive injectable conductive hydrogels as stimulating scaffolds for myocardial tissue engineering

Contact Info

Product

Resources

About