Tissue engineering of the tympanic membrane using electrospun PEOT/PBT copolymer scaffolds: A morphological in vitro study

Abstract

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Design, fabrication and characterization of composite piezoelectric ultrafine fibers for cochlear stimulation

“…suggesting an efficient cellular interaction with the piezoelectric substrate (Figure 11 C, D). Enhanced viability and function during dynamic culture have been observed in other applications and are invoked as a proof of reliability of biomimetic culture systems [32]. Further studies will be necessary to precisely demonstrate the hypothesis that BTNP/PVDF fibers can enhance the auditory performance in animal models and if their ability of attracting resident neurites of the spiral ganglion neurons will be confirmed in vivo.…”

“…Finally, the direct piezoelectric coefficient g 31 was calculated as: A PVDF uniaxially-poled metallized film (from Goodfellow Cambridge Ltd. Huntingdon, UK) was used as a positive control, whereas poly(ethylene oxide terephthalate)/poly(butylene terephthalate) (PEOT/PBT) randomly electrospun fiber mesh was used as a negative control for the experiment [32]. Measurements on piezoelectric fiber strips were repeated at least three times.…”

Preparation of P3HB4HB/(Gelatin + PVA) Composite Scaffolds by Coaxial Electrospinning and Its Biocompatibility Evaluation

“…According to the principle of mercury intrusion [ 16 , 17 ], mercury has no wettability to most solid materials, and it needs additional pressure to enter the solid hole. For the pore model, the size of the hole that mercury can enter and pressure conforms to the Washburn equation.…”

PEOT/PBT Guides Enhance Nerve Regeneration in Long Gap Defects

“…Changing the copolymer ratio of PBT to PEOT allows the material properties to be uniquely tuned in order to elicit a desired biological response, meanwhile retaining satisfactory biocompatibility . In addition to having limited adverse effects on the surrounding tissue during implantation, PEOT/PBT is flexible in terms of processing methods and has been used in various strategies for repairing different tissues such as tympanic membrane replacement, cartilage regeneration, coatings on dental and hip implants, and as bone cement restrictor which has been approved by the US Food and Drug Administration for clinical use in humans.…”

“…The composition of PEOT/PBT 300 55/45 was employed because it has proven cell adhesive properties and long resorption time (>6 months), suitable for providing long‐term support for cell growth . Furthermore, the PA 300 55/45 polymer can be readily processed by electrospinning, a method of fabricating polymeric fibrous meshes that exhibit topographical guidance for neurite growth and glial cell migration and can produce tissue scaffolds with tailored porosity . The resulting conduit is comprised of an oriented fibrous mesh that incorporates topographical guidance and exhibits pores that are 8–10 µm in diameter.…”