Tissue engineering of human ear pinna

Bhamare, Nilesh; Tardalkar, Kishor; Khadilkar, Archana; Parulekar, Pratima; Joshi, Meghnad

doi:10.1007/s10561-022-09991-7

Cited by 14 publications

(9 citation statements)

References 63 publications

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“…24 Bioprinted ears have been shown to develop new chondrocytes in animal models, and there is ongoing investigations for application in a human model. 25…”

Section: Use Of Three-dimensional Printing and Future Directionsmentioning

confidence: 99%

Contemporary Management of Microtia

et al. 2022

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Microtia techniques have evolved to improve aesthetic outcomes, reduce donor site morbidities, and reduce complications. Patients with microtia commonly have aural atresia associated with conductive hearing loss. We present the evolution of our technique for microtia reconstruction and considerations for hearing management in these patients. Keywords: Microtia, aural atresia, autologous rib reconstruction, contemporary management

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“…24 Bioprinted ears have been shown to develop new chondrocytes in animal models, and there is ongoing investigations for application in a human model. 25…”

Section: Use Of Three-dimensional Printing and Future Directionsmentioning

confidence: 99%

Contemporary Management of Microtia

et al. 2022

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“…Materials used for this purpose must be easy to shape and must maintain their shape stably over time. Some biomaterials combining scaffolds and cells have been used successfully in animal experiments and clinical trials [14,15,38]; however, when using such materials, it is difficult to achieve a balance between scaffold degradation and tissue organization, and foreign body reactions can also occur. In the field of facial plastic surgery, these events can pose a serious problem because they can lead to morphologic deformities and implant component exposure.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of shape-designable cartilage from human induced pluripotent stem cell-derived chondroprogenitors using a cell self-aggregation technique

Ota,

Takao,

Iwai

et al. 2023

Biomed. Mater.

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With the advancement of tissue engineering technologies, implantable materials have been developed for use in facial plastic surgery, including auriculoplasty and rhinoplasty. Tissue-engineered cartilage comprising only cells and cell-produced extracellular matrix is considered valuable as there is no need to consider problems associated with the absorption of scaffold materials and the generation of immune responses. However, it is exceedingly difficult to produce large-sized complex shapes of cartilage without the use of scaffolds. In this study, we describe the production of shape-designable cartilage using a novel cell self-aggregation technique (CAT) and chondroprogenitor cells derived from human induced pluripotent stem cells as the source. The method described does not require special equipment such as bio-3D printers, and the produced tissue can be induced into well-matured cartilage with abundant cartilage matrix in vitro. Using CAT, we were able to generate cartilage in the form of rings or tubes with adjustable inner diameter and curvature, over a range of several centimeters, without the use of scaffolds. The in vitro fabrication of shape-designable cartilage using CAT will undoubtedly contribute to developments in the field of facial plastic surgery.

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“…More and more people suffer from sensorineural hearing loss (SNHL) due to the aging of the population, long-term exposure to noise, genetics, diseases, drugs, trauma, and other factors. It has become a major medical problem affecting millions of people around the world. − At present, decellularized cochlear scaffolds have gradually become a research hotspot.…”

Section: The Application Of Decellularized Scaffolds In Tissue Engine...mentioning

confidence: 99%

Biomedical Application of Decellularized Scaffolds

Zhang,

Gao,

Jiang

et al. 2023

ACS Appl. Bio Mater.

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Tissue engineering of human ear pinna

Cited by 14 publications

References 63 publications

Contemporary Management of Microtia

Contemporary Management of Microtia

Fabrication of shape-designable cartilage from human induced pluripotent stem cell-derived chondroprogenitors using a cell self-aggregation technique

Biomedical Application of Decellularized Scaffolds

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