Tissue Engineering in Gynecology

Brownell, David; Chabaud, Stéphane; Bolduc, Stéphane

doi:10.3390/ijms232012319

Cited by 8 publications

(5 citation statements)

References 114 publications

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“…The vaginal epithelium is a stratified squamous layer that is stimulated by estrogen to produce glycogen. When these cells desquamate, the released glycogen is converted into lactic acid, resulting in a relatively low pH environment in the vagina [2,7,46]. This environment is impermissible for pathogenic bacteria growth and is crucial for vaginal health.…”

Section: Brief Histology Of Vagina and Biology Of Ecmmentioning

confidence: 99%

“…Congenital vaginal anomalies (CVA) significantly affect patients' quality of life, affect fertility, and have psychological impacts [1][2][3][4][5][6]. While surgical and non-surgical treatment options are available for treating vaginal defects, the low efficacy and long-term complications of these treatments necessitate developing alternative treatment options [7,8]. For example, repeated vaginal dilation is not convenient for the patients, and the surgical development of neovagina using tissue grafting is challenged by the unavailability of suitable donor tissues, graft failure, and the need for additional surgery for graft harvesting [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction

et al. 2023

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Congenital vaginal anomalies and pelvic organ prolapse affect different age groups of women and both have significant negative impacts on patients’ psychological well-being and quality of life. While surgical and non-surgical treatments are available for vaginal defects, their efficacy is limited, and they often result in long-term complications. Therefore, alternative treatment options are urgently needed. Fortunately, tissue-engineered scaffolds are promising new treatment modalities that provide an extracellular matrix (ECM)-like environment for vaginal cells to adhere, secrete ECM, and be remodeled by host cells. To this end, ECM-based scaffolds or the constructs that resemble ECM, generated by self-assembly, decellularization, or electrospinning techniques, have gained attention from both clinicians and researchers. These biomimetic scaffolds are highly similar to the native vaginal ECM and have great potential for clinical translation. This review article aims to discuss recent applications, challenges, and future perspectives of these scaffolds in vaginal reconstruction or repair strategies.

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Section: Brief Histology Of Vagina and Biology Of Ecmmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction

et al. 2023

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“…TE could eventually serve as a solution for persons with intersex disorders or trans-women. Full review articles have recently been published and will interest readers [65,274]. The glycogenated stratified squamous epithelium lines the vaginal lumen, sitting on a stroma.…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…Numbers describe procedure order. This figure was created with BioRender.com and modified from Brownell et al [274].…”

Section: Tissue Engineeringmentioning

confidence: 99%

Tissue Engineering for Gastrointestinal and Genitourinary Tracts

Elia¹,

Brownell²,

Chabaud³

et al. 2022

Preprint

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The gastrointestinal and genitourinary tracts share several similarities. Primarily, these tissues are composed of hollow structures lined by an epithelium through which materials need to flow with the help of peristalsis brought by muscle contraction. In the case of the gastrointestinal tract, solid or liquid food must circulate to be digested and absorbed and the waste products eliminated. In the case of the urinary tract, the urine produced by the kidneys must flow to the bladder, where it is stored until its elimination from the body. Finally, in the case of the vagina, it must allow the evacuation of blood during menstruation, accommodate the male sexual organ during coitus, and is the natural way to birth a child. The present review describes the anatomy, pathologies and treatments of such organs, emphasizing tissue engineering strategies.

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“…Tissue engineering has been shown to be a promising approach to repair damaged tissues/organs in the body by using biological substitutes through combining three-dimensional (3D) scaffolds, cells/stem cells and biomolecules and therefore overcome the hurdles in tissue or organ transplantation [5] . Tissue engineering has already made great success in treating problems for various tissues and organs, including bone [6] , blood vessel [7] , skin [8] , and bladder [9] .…”

Section: Introductionmentioning

confidence: 99%

Biomimicking Trilayer Scaffolds with Controlled Estradiol Release for Uterine Tissue Regeneration

Chen,

Li,

Zheng

et al. 2023

Preprint

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Scaffold-based tissue engineering provides an efficient approach for repairing uterine tissue defects and restoring fertility. In the current study, a novel trilayer tissue engineering scaffold with high similarity to the uterine tissue in structure was designed and fabricated via 4D printing, electrospinning and 3D bioprinting for uterine regeneration. Highly stretchable poly(L-lactide-co-trimethylene carbonate) (PLLA-co-TMC, “PTMC” in short)/thermoplastic polyurethane (TPU) polymer blend scaffolds were firstly made via 4D printing. To improve the biocompatibility, porous poly(lactic acid-co-glycolic acid) (PLGA)/gelatin methacryloyl (GelMA) fibers incorporated with polydopamine (PDA) particles were produced on PTMC/TPU scaffolds via electrospinning. Importantly, estradiol (E2) was encapsulated in PDA particles. The bilayer scaffolds thus produced could provide controlled and sustained release of E2. Subsequently, bone marrow derived mesenchymal stem cells (BMSCs) were mixed with gelatin methacryloyl (GelMA)-based inks and the formulated bioinks were used to fabricate a cell-laden hydrogel layer on the bilayer scaffolds via 3D bioprinting, forming ultimately biomimicking trilayer scaffolds for uterine tissue regeneration. The trilayer tissue engineering scaffolds thus formed exhibited a shape morphing ability by transforming from the planar shape to tubular structures when immersed in the culture medium at 37 ℃. The developed trilayer tissue engineering scaffolds would provide a new insight for uterine tissue regeneration.

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Tissue Engineering in Gynecology

Cited by 8 publications

References 114 publications

Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction

Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction

Tissue Engineering for Gastrointestinal and Genitourinary Tracts

Biomimicking Trilayer Scaffolds with Controlled Estradiol Release for Uterine Tissue Regeneration

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