Tissue Engineering and Stem Cell Therapy in Neurogenic Bladder Dysfunction: Current and Future Perspectives

Abstract

Tissue engineering (TE) is a rapidly evolving biomedical discipline that can play an important role in treating neurogenic bladder dysfunction and compensating for current conventional options’ shortcomings. This review aims to analyze the current status of preclinical and clinical trials and discuss what could be expected in the future based on the current state of the art. Although most preclinical studies provide promising results on the effectiveness of TE and stem cell therapies, the main limitations are mainly the very slow translation of preclinical trials to clinical trials, lack of quality research on neurogenic preconditions of neurogenic bladder dysfunction outside of the spinal cord injury and varying therapeutic methods of the existing research that lacks a standardized approach.

Incontinencia Urinaria en La Mujer: Enfoque Terapeutico Actual

“…Además de las nuevas tecnologías, se están explorando terapias innovadoras para el tratamiento de la incontinencia urinaria en la mujer. Estas terapias incluyen enfoques como la terapia con células madre para la regeneración de los tejidos dañados en el tracto urinario (28), la terapia con láser para el fortalecimiento de los tejidos y músculos del suelo pélvico(29), así como la terapia con ondas de choque para mejorar la función de la vejiga y reducir los síntomas de la incontinencia (30).…”

Editorial: From single stem cells to organoids, organ repair, and public health Volume II

“…Nevertheless, the mechanisms of recovery of apparently normal smooth muscle cell contractility in microtissues remains to be determined. Moreover, such muscle cells seem unlikely to benefit patients with neurogenic bladder dysfunction ( Topoliova et al, 2023 ) as is the case also for smooth muscle cells associated with the neurogenic disorders discussed above.…”

Adipose-Derived Stem Cells: Angiogenetic Potential and Utility in Tissue Engineering

“…These processes largely depend on factors such as cell types and sources, cell-seeding techniques, cell signaling, growth factors, scaffold-based approaches, bioreactors, vascularization strategies, etc. [5,[7][8][9][10]. Finding the proper source of stem cells for TE is one of the most attractive prospects for biologists and bioengineers.…”