Tissue Engineered Construct Design Principles

Reece, Gregory P.; Patrick, C.

doi:10.1016/b978-008042689-1/50012-1

Cited by 8 publications

(3 citation statements)

References 100 publications

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“…These design criteria are heavily influenced by the pore morphology in scaffolds. To help in the optimal design of scaffolds requires both accurately characterising the scaffold structure in 3D and an ability to characterise the bone regeneration process within the scaffold structure [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth

et al. 2009

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Section: Introductionmentioning

confidence: 99%

The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth

et al. 2009

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“…As the scaffolds for TE will be implanted in the human body, the scaffold materials should be non-antigenic, noncarcinogenic, non-toxic, and possess high cell/tissue biocompatibility so that they will not trigger any adverse cellular/tissue reactions after implantation. Besides material issues, the macro-and micro-structural properties of the scaffold are important, too (Reece and Patrick, 1998). Hence, a scaffold should fulfill a minimal set of properties, which are as follows: 1 be highly porous with a fully interconnected pore network for cell growth and neotissue formation as well as to allow for sufficient transport of nutrients and metabolic waste; 2 have suitable surface topography and material chemistry for cell attachment, proliferation, and differentiation; 3 possess mechanical properties which at least withstand the cell and wound contraction forces at the site of implantation; 4 be easily fabricated into a variety of shapes and sizes; and 5 possess interconnecting porosity so as to favor tissue integration and vascularity (Hutmacher et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Direct writing of chitosan scaffolds using a robotic system

Luo

Feng

Hutmacher

et al. 2005

Rapid Prototyping Journal

108

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Purpose -This paper aims to present a novel rapid prototyping (RP) fabrication methods and preliminary characterization for chitosan scaffolds. Design -A desktop rapid prototyping robot dispensing (RPBOD) system has been developed to fabricate scaffolds for tissue engineering (TE) applications. The system is a computer-controlled four-axis machine with a multiple-dispenser head. Neutralization of the acetic acid by the sodium hydroxide results in a precipitate to form a gel-like chitosan strand. The scaffold properties were characterized by scanning electron microscopy, porosity calculation and compression test. An example of fabrication of a freeform hydrogel scaffold is demonstrated. The required geometric data for the freeform scaffold were obtained from CT-scan images and the dispensing path control data were converted form its volume model. The applications of the scaffolds are discussed based on its potential for TE. Findings -It is shown that the RPBOD system can be interfaced with imaging techniques and computational modeling to produce scaffolds which can be customized in overall size and shape allowing tissue-engineered grafts to be tailored to specific applications or even for individual patients. Research limitations/implications -Important challenges for further research are the incorporation of growth factors, as well as cell seeding into the 3D dispensing plotting materials. Improvements regarding the mechanical properties of the scaffolds are also necessary. Originality/value -One of the important aspects of TE is the design scaffolds. For customized TE, it is essential to be able to fabricate 3D scaffolds of various geometric shapes, in order to repair tissue defects. RP or solid free-form fabrication techniques hold great promise for designing 3D customized scaffolds; yet traditional cell-seeding techniques may not provide enough cell mass for larger constructs. This paper presents a novel attempt to fabricate 3D scaffolds, using hydrogels which in the future can be combined with cells.

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“…Las muestras de tejido suelen ser tomadas del hueso trabecular de la cresta ilíaca y en algunos casos del hueso cortical [131,134]. No obstante, y aunque se ha empleado en muchos pacientes con un alto grado de eficacia, los casos en los que pueden ser utilizados es muy restrictivo debido a la cantidad de tejido autógrafo a extraer.…”

Section: Ingeniería Tisularunclassified

Síntesis, caracterización y aplicaciones biomédicas de redes de copolímeros basados en poliésteres.

Ivirico¹,

Luis²

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Tissue Engineered Construct Design Principles

Cited by 8 publications

References 100 publications

The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth

The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth

Direct writing of chitosan scaffolds using a robotic system

Síntesis, caracterización y aplicaciones biomédicas de redes de copolímeros basados en poliésteres.

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