Tissue-Engineered Bone With 3-Dimensionally Printed β-Tricalcium Phosphate and Polycaprolactone Scaffolds and Early Implantation: An In Vivo Pilot Study in a Porcine Mandible Model

Konopnicki, S.; Sharaf, Basel; Resnick, Cory M.; Patenaude, Adam; Pogal-Sussman, Tracy; Hwang, Kyung‐Gyun; Abukawa, Harutsugi; Troulis, Maria J.

doi:10.1016/j.joms.2015.01.021

Cited by 61 publications

(84 citation statements)

References 32 publications

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“…The weight ratio of polymer/mineral charge differed from one study to another: usually the amount of mineral remained under 40% of the final material weight, except in eight studies among 62 . The most used polymer/mineral weight ratio was 80/20.…”

Section: Resultsmentioning

confidence: 98%

“…PCL, PLA, and PLGA were the most used polymers. PCL was the most used polymer as it was found in 29 articles . PLA was used in 13 studies and PLGA in 14 studies .…”

Section: Resultsmentioning

confidence: 99%

“…Several minerals can be used to increase polymer bioactivity. TCP was the most frequent and it was used in 32 studies . HA was the second most used mineral, in its non‐modified form in 25 studies, its carbonated form in two studies, its sintered form in one study or just as an apatite coating in two studies .…”

Section: Resultsmentioning

confidence: 99%

“…Rats were used in three studies with a calvaria defect or a femoral defect . Pig was used in three studies, with a mandibular defect or a temporal defect . Goat were used in two publications, with a femoral defect and once with a calvaria defect .…”

Section: Resultsmentioning

confidence: 99%

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3D printed polymer–mineral composite biomaterials for bone tissue engineering: Fabrication and characterization

et al. 2019

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Applications in additive manufacturing technologies for bone tissue engineering applications requires the development of new biomaterials formulations. Different three‐dimensional (3D) printing technologies can be used and polymers are commonly employed to fabricate 3D printed bone scaffolds. However, these materials used alone do not possess an effective osteopromotive potential for bone regeneration. A growing number of studies report the combination of polymers with minerals in order to improve their bioactivity. This review exposes the state‐of‐the‐art of existing 3D printed composite biomaterials combining polymers and minerals for bone tissue engineering. Characterization techniques to assess scaffold properties are also discussed. Several parameters must be considered to fabricate a 3D printed material for bone repair (3D printing method, type of polymer/mineral combination and ratio) because all of them affect final properties of the material. Each polymer and mineral has its own advantages and drawbacks and numerous composites are described in the literature. Each component of these composite materials brings specific properties and their combination can improve the biological integration of the 3D printed scaffold. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2579–2595, 2019.

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Section: Resultsmentioning

confidence: 98%

“…PCL, PLA, and PLGA were the most used polymers. PCL was the most used polymer as it was found in 29 articles . PLA was used in 13 studies and PLGA in 14 studies .…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

3D printed polymer–mineral composite biomaterials for bone tissue engineering: Fabrication and characterization

et al. 2019

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“…This illustrates the influence of phase composition on resorption of ceramic 3D scaffolds. 41 Furthermore, Konopnicki et al 42 fabricated 3DP 50 % PCL and 50 % TCP composite scaffolds seeded with porcine bone marrow progenitor cells (pBMP) and implanted them for 8 weeks into mandibular defects in minipigs. Unseeded scaffolds were used as controls.…”

Section: In Vitro and In Vivo Testing Of 3dp Bone Scaffoldsmentioning

confidence: 99%

3D Printing of Personalized Artificial Bone Scaffolds

Jariwala

Lewis

Bushman

et al. 2015

3D Printing and Additive Manufacturing

127

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Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics

Garot

Bettega

Picart

2020

Adv Funct Materials

115

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Additive manufacturing (AM) allows the fabrication of customized bone scaffolds in terms of shape, pore size, material type, and mechanical properties. Combined with the possibility to obtain a precise 3D image of the bone defects using computed tomography or magnetic resonance imaging, it is now possible to manufacture implants for patient‐specific bone regeneration. This paper reviews the state‐of‐the‐art of the different materials and AM techniques used for the fabrication of 3D‐printed scaffolds in the field of bone tissue engineering. Their advantages and drawbacks are highlighted. For materials, specific criteria, are extracted from a literature study: biomimetism to native bone, mechanical properties, biodegradability, ability to be imaged (implantation and follow‐up period), histological performances, and sterilization process. AM techniques can be classified in three major categories: extrusion‐based, powder‐based, and vat photopolymerization. Their price, ease of use, and space requirement are analyzed. Different combinations of materials/AM techniques appear to be the most relevant depending on the targeted clinical applications (implantation site, presence of mechanical constraints, temporary or permanent implant). Finally, some barriers impeding the translation to human clinics are identified, notably the sterilization process.

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Tissue-Engineered Bone With 3-Dimensionally Printed β-Tricalcium Phosphate and Polycaprolactone Scaffolds and Early Implantation: An In Vivo Pilot Study in a Porcine Mandible Model

Cited by 61 publications

References 32 publications

3D printed polymer–mineral composite biomaterials for bone tissue engineering: Fabrication and characterization

3D printed polymer–mineral composite biomaterials for bone tissue engineering: Fabrication and characterization

3D Printing of Personalized Artificial Bone Scaffolds

Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics

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