Tissue Electrolyte Alteration in Disseminated Myocardial Necrosis*

Role of Magnesium in Cardiac Disease

“…In experiments with rats and dogs injection of high doses of the ß-agonist isoproterenol or of the -agonist phenylephrine and also of the a-and ß-active adrenalin produced a loss of cardiac Mg 2+ in the ränge of 12-39% (23,(65)(66)(67)(68). The loss of Mg 2+ was complete within 0.5-1 hours (67) and was shown to be "cardiospecific" since in skeletal muscle, liver, erythrocytes and bone no effect could be observed (23,67).…”

“…In experiments with rats and dogs injection of high doses of the ß-agonist isoproterenol or of the -agonist phenylephrine and also of the a-and ß-active adrenalin produced a loss of cardiac Mg 2+ in the ränge of 12-39% (23,(65)(66)(67)(68). The loss of Mg 2+ was complete within 0.5-1 hours (67) and was shown to be "cardiospecific" since in skeletal muscle, liver, erythrocytes and bone no effect could be observed (23,67). The cardiac Ca 2+ content showed a more pronounced increase of 2-3 fold (23,68,69) but the time course was different for loss of Mg 2+ and gain of Ca 2+ ,.indicating that these two effects are not coupled, äs already known from experiments on 28 …”

“…The loss of Mg 2+ was complete within 0.5-1 hours (67) and was shown to be "cardiospecific" since in skeletal muscle, liver, erythrocytes and bone no effect could be observed (23,67). The cardiac Ca 2+ content showed a more pronounced increase of 2-3 fold (23,68,69) but the time course was different for loss of Mg 2+ and gain of Ca 2+ ,.indicating that these two effects are not coupled, äs already known from experiments on 28 …”

“…It should be noted that these changes in electrolyte content could be prevented by the specific a-or ß-antagonists (23,24,65 (31).…”

“…In animal experiments, injection b'f catecholamines also rapidly produced disseminated myocardial necroses (23,24,65) and/or cardiac hypertfophy (for review see I.e. (71)).…”