Tissue distribution, metabolism and absorption of Rhizoma Paridis Saponins in the rats

Wang, Genbei; Hao, Ruijia; Liu, Yu; Wang, Yu; Man, Shuli; Gao, Wenyuan

doi:10.1016/j.jep.2021.114038

Cited by 11 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, it was also found to undergo hydrolysis by intestinal flora and was mainly distributed in the lungs and liver, suggesting limited target tissue delivery, [81] and a study reported that gracillin was consistently absorbed through the intestine (jejunum and ileum). [82] Various investigations expressed that gracillin is distributed in the heart, spleen, liver, lungs, and kidneys, [81,83,84] and has the capability to cross the blood-brain barrier (BBB) as it was found in brain tissues. [83]…”

Section: Physicochemical Properties and Biopharmaceutical Profile Of ...mentioning

confidence: 99%

See 1 more Smart Citation

Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches

Bhuia,

Chowdhury,

Sonia

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

With the increasing prevalence of cancer and the toxic side effects of synthetic drugs, natural products are being developed as promising therapeutic approaches. Gracillin is a naturally occurring triterpenoid steroidal saponin with several therapeutic activities. It is obtained as a major compound from different Dioscorea species. This review was designated to summarize the research progress on the anti‐cancer activities of gracillin focusing on the underlying cellular and molecular mechanisms, as well as its pharmacokinetic features. The data were collected (up to date as of May 1, 2023) from various reliable and authentic literatures comprising PubMed, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar. The findings demonstrated that gracillin displays promising anticancer effects through various molecular mechanisms, including anti‐inflammatory effects, apoptotic cell death, induction of oxidative stress, cytotoxicity, induction of genotoxicity, cell cycle arrest, anti‐proliferative effect, autophagy, inhibition of glycolysis, and blocking of cancer cell migration. Additionally, this review highlighted the pharmacokinetic features of gracillin, indicating its lower oral bioavailability. As a conclusion, it can be proposed that gracillin could serve as a hopeful chemotherapeutic agent. However, further extensive clinical research is recommended to establish its safety, efficacy, and therapeutic potential in cancer treatment.

show abstract

Section: Physicochemical Properties and Biopharmaceutical Profile Of ...mentioning

confidence: 99%

“…[82] Various investigations expressed that gracillin is distributed in the heart, spleen, liver, lungs, and kidneys, [81,83,84] and has the capability to cross the blood-brain barrier (BBB) as it was found in brain tissues. [83]…”

Section: Physicochemical Properties and Biopharmaceutical Profile Of ...mentioning

confidence: 99%

Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches

Bhuia,

Chowdhury,

Sonia

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…Finally, the gradient was rapidly decreased to its initial condition for 0.1 min then maintained at 10% B for the next 2.9 min. Samples of a 5 ml volume were injected for analysis (Wang et al, 2021).…”

Section: Determination Of Sucrose Glucose and Fructose Concentrationmentioning

confidence: 99%

The synthesis of Paris saponin VII mainly occurs in leaves and is promoted by light intensity

et al. 2023

View full text Add to dashboard Cite

Unraveling the specific organs and tissues involved in saponin synthesis, as well as the light regulatory mechanisms, is crucial for improving the quality of artificially cultivated medicinal materials of Paris plants. Paris saponin VII (PS VII), a high-value active ingredient, is found in almost all organs of Paris plant species. In this study, we focused on Paris polyphylla var. yunnanensis (Franch.) Hand. - Mzt. (PPY) and found that PS VII synthesis predominantly occurs in leaves and is increased by high light intensity. This intriguing discovery has unveiled the potential for manipulating non-traditional medicinal organ leaves to improve the quality of medicinal organ rhizomes. The analysis of the impact of organ differences on saponin concentration in P. polyphylla var. chinensis (Franch.) Hara (PPC), P. fargesii Franch. (PF), and PPY revealed consistency among the three Paris species and was mainly dominated by PS VII. Notably, the leaves and stems exhibited much higher proportions of PS VII than other organs, accounting for 80–90% of the four main saponins. Among the three Paris species, PPY had the highest concentration of PS VII and was selected for subsequent experiments. Further investigations on saponin subcellular localization, temporal variation, and stem wound fluid composition demonstrated that PS VII is synthesized in mesophyll cells, released into the intercellular space through exocytosis, and then transported to the rhizome via vascular tissue. These findings confirm the significant role of leaves in PS VII synthesis. Additionally, a 13C-glucose feeding to trace PS VII biosynthesis revealed that only PS VII in the leaves exhibited incorporation of the labeled carbon, despite conducting 13C-glucose feeding in leaves, stems, rhizomes, and roots. Thus, the leaves are indeed the primary organ for PS VII synthesis in PPY. Furthermore, compared with plants under 100 μmol m−2 s−1, plants under 400 μmol m−2 s−1 exhibited a higher PS VII concentration, particularly in the upper epidermal cells of the leaves. We propose that high light intensity promotes PS VII synthesis in leaves through three mechanisms: (1) increased availability of substrates for saponin synthesis; (2) protection of leaves from high light damage through enhanced saponin synthesis; and (3) enhanced compartmentalization of saponins within the leaves, which in turn feedback regulates saponin synthesis.

show abstract

“…Due to its wide range of pharmacological activities and medicinal properties, it has been used in the prevention and treatment of neurological diseases, 7 such as Alzheimer's disease, 8 spinal cord injury, 9 cerebral ischemia reperfusion 10 and neuropathic pain. 11 It has been reported that oral diosgenin can be retained in the intestine for a long time and can be detected in the brain, 12 suggesting that diosgenin can penetrate the blood-brain barrier and may regulate the gut microbiota. However, the effect of diosgenin on neuropathic pain caused by OXA and whether it is involved in the regulation of gut microbiota are unclear.…”

Section: Introductionmentioning

confidence: 99%

Diosgenin relieves oxaliplatin-induced pain by affecting TLR4/NF-κB inflammatory signaling and the gut microbiota

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

Tissue distribution, metabolism and absorption of Rhizoma Paridis Saponins in the rats

Cited by 11 publications

References 27 publications

Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches

Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches

The synthesis of Paris saponin VII mainly occurs in leaves and is promoted by light intensity

Diosgenin relieves oxaliplatin-induced pain by affecting TLR4/NF-κB inflammatory signaling and the gut microbiota

Contact Info

Product

Resources

About