Diosgenin relieves oxaliplatin-induced pain by affecting TLR4/NF-κB inflammatory signaling and the gut microbiota

Man, Shuli; Xie, Lu; Liu, Xuanshuo; Wang, Genbei; Liu, Changxiao; Gao, Wensheng

doi:10.1039/d2fo02877h

Cited by 10 publications

(3 citation statements)

References 42 publications

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“…This, diosgenin has neuroprotective and antioxidant activity, modulates neurotransmitters, is antiapoptotic and anti-inflammatory, attenuates Ca 2+ influx modulating neurotrophic factors, inhibits tau phosphorylation, and can regenerate neural networks (Sun et al, 2015). Some of these activities may well stem from the repression of TNF-α, IL-1β, and IL-6 levels and the NF-κB pathway (Zhang et al, 2017;Man et al, 2023) in addition to the aforementioned actions. Because of these diverse properties, diosgenin can generate mnemonic/ antidepressant/anxiolytic outcomes in our behavioral paradigms following SPS exposure.…”

Section: Discussionmentioning

confidence: 99%

Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress

Malik,

Usman,

Arif

et al. 2023

Front. Pharmacol.

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Introduction: Post-traumatic stress disorder (PTSD) is a chronic mental illness triggered by traumatic experiences such as wars, natural disasters, or catastrophes, and it is characterized by anxiety, depression and cognitive impairment. Diosgenin is a steroidal sapogenin with known neuroprotective and antioxidant properties. This study aimed to assess the pharmacological potential of diosgenin in a single prolonged stress (SPS) model of PTSD, plus other behavioral models along with any consequent alterations in brain neurochemistry in male mice.Methodology: SPS was induced by restraining animals for 2 h, followed by 20 min of forced swim, recuperation for 15 min, and finally, exposure to ether to induce anesthesia. The SPS-exposed animals were treated with diosgenin (20, 40, and 60 mg/kg) and compared with the positive controls, fluoxetine or donepezil, then they were observed for any changes in anxiety/depression-like behaviors, and cognitive impairment. After behavioral screening, postmortem serotonin, noradrenaline, dopamine, vitamin C, adenosine and its metabolites inosine and hypoxanthine were quantified in the frontal cortex, hippocampus, and striatum by high-performance liquid chromatography. Additionally, animal serum was screened for changes in corticosterone levels.Results: The results showed that diosgenin reversed anxiety- and depression-like behaviors, and ameliorated cognitive impairment in a dose-dependent manner. Additionally, diosgenin restored monoamine and vitamin C levels dose-dependently and modulated adenosine and its metabolites in the brain regions. Diosgenin also reinstated otherwise increased serum corticosterone levels in SPS mice.Conclusion: The findings suggest that diosgenin may be a potential candidate for improving symptoms of PTSD.

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Section: Discussionmentioning

confidence: 99%

Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress

Malik,

Usman,

Arif

et al. 2023

Front. Pharmacol.

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“…These observations are in accordance with the fact that in vivo treatment in mice with the phytosteroid diosgenin reversed oxaliplatininduced peripheral neuropathy parameter values (e.g., mechanical withdrawal threshold and cold hyperalgesia). Again, treatment of the animals with FMT indicated that the pain ameliorating effect of diosgenin is GM-dependent [138].…”

Section: Trauma-induced Neuropathic Painmentioning

confidence: 95%

Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions

Calabro

Kankowski

Cescon

et al. 2023

IJMS

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It has been widely demonstrated that the gut microbiota is responsible for essential functions in human health and that its perturbation is implicated in the development and progression of a growing list of diseases. The number of studies evaluating how the gut microbiota interacts with and influences other organs and systems in the body and vice versa is constantly increasing and several ‘gut–organ axes’ have already been defined. Recently, the view on the link between the gut microbiota (GM) and the peripheral nervous system (PNS) has become broader by exceeding the fact that the PNS can serve as a systemic carrier of GM-derived metabolites and products to other organs. The PNS as the communication network between the central nervous system and the periphery of the body and internal organs can rather be affected itself by GM perturbation. In this review, we summarize the current knowledge about the impact of gut microbiota on the PNS, with regard to its somatic and autonomic divisions, in physiological, regenerative and pathological conditions.

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“…In another study in mice, it was proven that diosgenin, a steroid sapogenin found in fenugreek seeds and yam, could exert an analgesic effect in oxaliplatin-induced pain. The analgesic effect can be attributed to its influence on the TLR-4/NF-jB inflammatory signalling pathway [74].…”

Section: Chemotherapy-induced Peripheral Neuropathymentioning

confidence: 99%

Gut Microbiota Modulation and Its Implications on Neuropathic Pain: A Comprehensive Literature Review

Corriero,

Giglio,

Inchingolo

et al. 2023

Pain Ther

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Neuropathic pain (NP) is a chronic pain disorder arising from somatosensory nervous system impairment. Extensive evidence supports the notion that the gut microbiota (GM) is crucial in maintaining human health by performing vital tasks. At the same time, its disruption has been linked to the emergence and advancement of an expanding range of disorders, including NP, in which GM could play a role in its pathophysiology. The crosstalk between the nervous system and GM happens through immune mediators, metabolites, and nervous structures and involves both central and peripheral nervous systems. This literature review aims to thoroughly investigate the function of modulating GM in the treatment of NP. It will achieve this by integrating existing knowledge, identifying underlying mechanisms, and evaluating the possible clinical consequences of exploiting the gut-brain axis. We will cover the main therapeutic applications of the described GM-modulators, such as probiotics, faecal microbiota transplantation, dietary supplements and emotional support, to the main kinds of NP in which any evidence, even if only pre-clinical, has been unravelled in recent years. The explored NP areas include chemotherapy-induced peripheral neuropathy, diabetic neuropathy, trauma-induced neuropathic pain, trigeminal neuralgia, postherpetic neuralgia and low back pain.

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Diosgenin relieves oxaliplatin-induced pain by affecting TLR4/NF-κB inflammatory signaling and the gut microbiota

Abstract: Diosgenin extracted from fenugreek, yam and other foods has a wide range of pharmacological activities especial for the treatment of pain and other nervous system diseases. However, its role in...

Cited by 10 publications

References 42 publications

Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress

Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress

Impact of Gut Microbiota on the Peripheral Nervous System in Physiological, Regenerative and Pathological Conditions

Gut Microbiota Modulation and Its Implications on Neuropathic Pain: A Comprehensive Literature Review

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