Tissue distribution and pulmonary damage in rats following acute inhaiation of methylmethacrylate

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

“…In addition, higher concentrations of methyl methacrylate are also related to alterations or lesions in several organs, such as the liver, kidney, brain, and lung. 69,70 Furthermore, Ballestri et al 62 assessed the presence of granulomatosis in the liver and kidney of patients with malocclusion, bruxism, and worn dental prostheses and suggested that the systemic foreign body granulomatosis found in these patients can be associated with worn dental prostheses, since the particles isolated from the liver-kidney granulomas contained feldspars, the main component of porcelain.…”

Airborne Exposure of Methyl Methacrylate During Simulated Total Hip Arthroplasty and Fabrication of Antibiotic Beads

“…An exposure to MMA at 15,000 ppm for 8 hours resulted in death of rats [12]. Lesser exposure levels have been associated with mucosal irritation, liver necrosis, brain damage, and lung complications [3,[13][14][15]. Pulmonary toxicity has been noted in animal models at levels as low as 100 ppm for one hour [14] and has been observed in industrial workers with chronic MMA exposure [16,17].…”

“…Lesser exposure levels have been associated with mucosal irritation, liver necrosis, brain damage, and lung complications [3,[13][14][15]. Pulmonary toxicity has been noted in animal models at levels as low as 100 ppm for one hour [14] and has been observed in industrial workers with chronic MMA exposure [16,17]. The carcinogenic potential and gestational effects of MMA remain uncertain [18][19][20].…”

Richtwerte für Methylmethacrylat in der Innenraumluft

“…Nach inhalativer Exposition von Ratten gegen 395,9 mg/ 3 MMA für 1, 2, 3, und 4 h, wurden unabhängig von Expositionsdauer 114 mg/L im Blut, 20,6 µg/g in der Lunge und 25,24 µg/g im Gehirn gefunden [17], was auf eine Sättigung in allen drei Geweben hinweist.…”