Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

Cintra, Luciano Tavares Ângelo; Estrela, Carlos; Azuma, Mariane Maffei; Queiroz, Índia Olinta de Azevedo; Kawai, Toshihisa; Gomes‐Filho, João Eduardo

doi:10.1590/1807-3107bor-2018.vol32.0068

Cited by 35 publications

(34 citation statements)

References 100 publications

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“…Even though people with diabetes do not necessarily have more caries [12], except possibly if diabetes is poorly controlled [33,35], they experience greater risk of periapical lesions in the jaw bone that seem to be present more often and to be larger in size and take longer to heal compared to normo-glycemic people [38][39][40][41], especially when poorly controlled [42]. The result of untreated caries is eventually the necrosis of the pulp (''nerve") inside the tooth, upon which the various substances from the breakdown of the dead nerves, blood, and connective tissue discharge out through the end of the root of the tooth (apex) and into the surrounding jaw bone and into the systemic blood stream.…”

Section: Periapical Lesionsmentioning

confidence: 99%

IDF Diabetes Atlas: Diabetes and oral health – A two-way relationship of clinical importance

Borgnakke

2019

Diabetes Research and Clinical Practice

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The current scientific evidence for the bi-directional associations between oral health and diabetes is summarized. The universal biologic mechanisms and demographic and behavioral risk drivers underlying these associations in both directions are also described. Dysglycemia, even slightly elevated blood sugar levels, adversely affects oral health, manifesting itself in several oral diseases and conditions. In the opposite direction, any oral infection with its subsequent local and systemic inflammatory responses adversely affects blood glucose levels. Moreover, painful, mobile, or missing teeth may lead to intake of soft food items representing a sub-optimal diet and hence poor nutrition, and thereby contribute to incident type 2 diabetes or to poorer glucose control in existing diabetes. Treatment of inflammation related oral conditions, such as non-surgical periodontal treatment and extraction of infected teeth, can lead to a clinically significant decrease in blood glucose levels. Attention to infectious oral diseases and referral to dental care professionals for treatment can therefore be an important novel tool for medical care professionals in preventing and managing diabetes mellitus. Dental professionals can detect unrecognized potential dysglycemia and refer for medical examination. Such interprofessional, patient centered care may contribute to improved health, wellbeing, and quality of life in people with diabetes.

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Section: Periapical Lesionsmentioning

confidence: 99%

IDF Diabetes Atlas: Diabetes and oral health – A two-way relationship of clinical importance

Borgnakke

2019

Diabetes Research and Clinical Practice

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“…Endodontic medicine has developed, with increasing numbers of reports describing the association between periapical inflammation and systemic diseases [8,9]. Numerous studies in animals and humans suggest the existence of a link between apical periodontitis and some systemic diseases [8,9,[12][13][14][15][16]. The possible connection between diabetes and apical periodontitis have been widely investigated in the last decade [8,[17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis

Pérez‐Losada

Estrugo‐Devesa

Castellanos-Cosano

et al. 2020

JCM

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Objective: Investigate if there is an association between apical periodontitis and diabetes mellitus. Material and methods: A bibliographic search was performed on Medline/PubMed, Scopus and Cochrane databases using the keywords apical periodontitis and diabetes mellitus. Published papers written in English and performed on animals or humans were included. Meta-analysis was performed using the OpenMeta (analyst) tool for the statistical analysis. The variables analyzed were the prevalence of Apical Periodontitis (AP) among teeth and patients with Diabetes Mellitus (DM). Results: Of the total studies found, only 21 met the inclusion criteria. Ten clinical studies on animals, ten studies on humans and a systematic review were included. Meta-analysis shows that the prevalence of teeth with apical periodontitis among patients with diabetes mellitus has an odds ratio of 1.166 corresponding to 507 teeth with AP + DM and 534 teeth with AP without DM. The prevalence of patients with AP and DM shows an odds ratio of 1.552 where 91 patients had AP + DM and 582 patients AP without DM. Conclusion: Scientific evidence suggests that there could be a common physiopathological factor between apical periodontitis and diabetes mellitus but more prospective studies are needed to investigate the association between these two diseases.

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“…2015, Cintra et al . 2018) and one did not address the aim of the present umbrella review (Aminoshariae et al . 2017).…”

Section: Resultsmentioning

confidence: 97%

Association between cardiovascular diseases and apical periodontitis: an umbrella review

et al. 2020

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Background The existence of an association between cardiovascular diseases (CVDs) and apical periodontitis (AP) remains unclear because results obtained from previous clinical studies and reviews are inconsistent or inconclusive. Objective To conduct an umbrella review to determine whether there is an association between CVDs and the prevalence of AP in adults. Methods The protocol of the review was registered in the PROSPERO database (CRD42020185753). The literature search was conducted using the following electronic databases: Clarivate Analytics’ Web of Science Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to May, 2020, with no language restrictions. Systematic reviews with or without meta‐analysis that evaluated the association between CVDs and AP were included. Other types of studies, including narrative reviews, were excluded. Two reviewers independently performed a literature search, data extraction and quality assessment of included studies. Any disagreements or doubts were resolved by a third reviewer. The quality of the reviews was assessed using the AMSTAR 2 tool (A measurement tool to assess systematic reviews), with 16 items. A final categorization of the systematic reviews classified each as of ‘high’, ‘moderate’, ‘low’ or ‘critically low’ quality. Results Four systematic reviews were included in the current review. Three reviews were graded by AMSTAR 2 as ‘moderate’ quality, whereas one review was graded as ‘critically low’ quality. Discussion Only one systematic review included a meta‐analysis. Substantial heterogeneity amongst the primary studies included within each systematic review was notable in preventing a pooled analysis. Conclusions From the limited ‘moderate’ to ‘critically low’ quality evidence available, the current umbrella review concluded that a weak association exists between CVDs and AP. In the future, well‐designed, longitudinal clinical studies with long‐term follow‐up are required.

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Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

Cited by 35 publications

References 100 publications

IDF Diabetes Atlas: Diabetes and oral health – A two-way relationship of clinical importance

IDF Diabetes Atlas: Diabetes and oral health – A two-way relationship of clinical importance

Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis

Association between cardiovascular diseases and apical periodontitis: an umbrella review

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