Tissue distribution and elimination of florfenicol in crucian carp (Carassius auratus cuvieri) after a single dose intramuscular or oral administration

The pharmacokinetics of florfenicol (FF) and its metabolite, florfenicol amine (FFA), were studied in rice field eel (Monopterus albus) after a single dose (20 mg/kg) by intramuscular (i.m.) or oral gavage (p.o.) dose at 25 °C. The elimination half-lives (t1/2β ), peak concentration of FF (Cmax ), and time to reach FF peak concentration (Tmax ) in plasma were estimated as 18.39 h, 10.83 μg/mL, and 7.00 h, respectively, after i.m. injection and 13.46 h, 8.37 μg/mL, and 5 h, respectively, after p.o. administration. The Tmax values of FF in tissues (i.e., kidney, muscle, and liver) were larger for i.m. injection compared with those for p.o. administration. The t1/2β had the following order kidney>muscle>liver for i.m. administrated and kidney>liver>muscle for p.o. administrated. The largest area under the concentration-time curve (AUC) was calculated to be 384.29 mg·h/kg after i.m. dosing, and the mean residence time (MRT) was 42.46 h by oral administration in kidney. FFA was also found in all tissues with a lower concentration than FF for both i.m. and p.o. administrations throughout the study. The elimination of FFA was slow with a t1/2β between 18.19 and 47.80 h in plasma and tissues. The mean metabolic rate of FFA for i.m. and p.o. administrations was >23.30%.

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“…administration. This is consistent with the result found in crucian carp, Carassius auratus cuvieri (Sun et al. , 2010; Zhao et al.…”

Section: Discussionsupporting

confidence: 93%

“…In contrast, the order in crucian carp was liver > bile > gill > muscle > kidney after a single‐dose injection and bile > gill > kidney ≈ muscle > liver after p.o. administration (Sun et al. , 2010).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in rice field eel (Monopterus albus) after a single‐dose intramuscular or oral administration

Xie

Chen

et al. 2012

Vet Pharm & Therapeutics

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“…This is probably because the liver has digestive and metabolic functions and therefore, the drug enters first into the liver before it reaches the muscle, kidney, and other tissues. This was consistent with the results reported in previous studies (Elema, 1996;Bowser, 2009;Sun et al, 2010). The drug concentration in the liver declined, eventually peaking H: healthy; D: diseased; A and B: intercepts of the two phases; α and β: the rate constants of the distribution and elimination phases; K a : absorption rate constant; K 10 : the elimination rate constant from the central compartment; K 12 : the first-order rate constant of transporting from central to periphery compartment; K 21 : the first-order rate constant of transporting from periphery to central compartment; T 1/2α and T 1/2β : half-lives of the two phases; T 1/ 2Ka : half-lives of the absorption; C max : the peak concentration of a drug after administration; T peak: time to reach the maximum concentration; AUC: the area under the curve to infinity; CLs: total body clearance; Vd: volume of distribution at steady-state after 10 h oral administration owing to enterohepatic circulation.…”

Section: Discussionsupporting

confidence: 83%

“…There are some reports of its pharmacokinetics determined in Oncorhynchus mykiss, Piaractus brachypomus, P. crocea, Gadus morhua, Salmo salar, Acipenser baeri, Anguilla anguilla, Tilapia, Silurus asotus, and Crucian carp (Horsberg et al, 1996;Lunden and Bylund, 2000;Samuelsen et al, 2003;Lewbart et al, 2005;Park et al, 2006;Feng and Jia, 2008;Bowser, 2009;Sun et al, 2010;Qin et al, 2010;Xie et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Study of Florfenicol in Healthy and Vibriosis-infectedPseudosciaena croceaafter Oral Administration

Wang

Han

Jin

et al. 2015

JABC

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The pharmacokinetics of florfenicol were studied in healthy and vibriosis-infected large yellow croaker (Pseudosciaena crocea) following administration of a single oral dose of 20 mg·kg −1 at 25±2 o C. After oral administration, florfenicol levels in tissues (liver, kidney, muscle, serum, and skin) were analyzed using high-performance liquid chromatography. A two-compartment open model was used to describe the pharmacokinetics of florfenicol following oral administration. Compared to the healthy group, the absorption rate of vibriosis-infected fish significantly decreased, peak-time (T max ) delayed, maximum concentration (C max ) declined, total body clearance decreased, the elimination half-life (T 1/2β ) was extended, and the area under the curve increased. These results indicate that a 20 mg·kg −1 oral dose of florfenicol administered once daily continuously for 4 or 5 days can be used for the treatment of Vibrio alginolyticus infection in large yellow croaker (Pseudosciaena crocea).

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“…O florfenicol é um antibiótico sintético que apresenta largo espectro ativo contra diversas bactérias gram-negativas e gram-positivas (Schering-Plough Animal Health, 2005). No entanto, ainda não há recomendação para seu uso na incubação de ovos de peixes neotropicais, apenas relatos do produto adicionado à ração (Schering-Plough Animal Health, 2005;Soto et al, 2013), aplicado diretamente nos peixes (Sun et al, 2010) ou bioencapsulado a náuplios de Artemia sp. para ser oferecido às larvas (Roiha et al, 2010).…”

Section: Incubation Of "Pacamã" Eggs With Florfenicolunclassified

Incubação de ovos de pacamã com florfenicol

Batista

Filho

Takata

et al. 2014

Pesq. agropec. bras.

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Resumo -O objetivo deste trabalho foi avaliar o efeito de doses de florfenicol na incubação de ovos de pacamã (Lophiosilurus alexandri). Na primeira etapa, os ovos foram submetidos a concentrações de florfenicol entre 0 e 500 mg L -1 , durante 24 horas. Na segunda etapa, as larvas foram observadas até o sétimo dia após a eclosão. Na terceira etapa, as larvas foram alimentadas por dez dias. Peso e comprimento apresentaram respostas que variaram de acordo com a fase de desenvolvimento e as concentrações de florfenicol. Concentrações menores que 309 mg L -1 de florfenicol podem ser usadas sem afetar as larvas nas fases posteriores.Termos para indexação: Lophiosilurus alexandri, desenvolvimento inicial, tratamento preventivo. Incubation of "pacamã" eggs with florfenicolAbstract -The objective of this work was to evaluate the effect of florfenicol doses on the incubation of "pacamã" (Lophiosilurus alexandri) eggs. In the first phase, eggs were subjected to florfenicol doses between 0 and 500 mg L -1 , for 24 hours. In the second phase, larvae were observed until the seventh day after hatching. In the third phase, larvae were fed for ten days. Weight and length showed responses that varied according to the development stage and to florfenicol doses. Doses lower than 309 mg L -1 florfenicol can be used without affecting larvae in later stages.

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Tissue distribution and elimination of florfenicol in crucian carp (Carassius auratus cuvieri) after a single dose intramuscular or oral administration

Cited by 32 publications

References 20 publications

Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in rice field eel (Monopterus albus) after a single‐dose intramuscular or oral administration

Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in rice field eel (Monopterus albus) after a single‐dose intramuscular or oral administration

Pharmacokinetic Study of Florfenicol in Healthy and Vibriosis-infectedPseudosciaena croceaafter Oral Administration

Incubação de ovos de pacamã com florfenicol

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