Tissue Culture in Pharmacology

Metabolism of carbaryl (1-naphthyl N-methylcarbamate) in human embryonic lung cell cultures

“…Presently, however, only one paper on the metabolism of carbaryl in cell cultures has been published, indicating that investigators in insecticide toxicology and chemistry have just begun to use tissue or cell culture systems as a research tool. Cell cultures provide a means for investigating the direct action of pesticides on cells or tissues in the absence of the complex system of a whole organism (Rosenoer, 1966). Baron and Locke (1970) first published work on the metabolism of carbaryl in a cell culture system using an established cell line, L-132 human embryonic lung cells.…”

Metabolism in human embryonic lung cell cultures of three phenylurea herbicides: chlorotoluron, fluometuron, and metobromuron

“…Cell culture systems provide a very useful method for investigating the direct actions of xenobiotics on cells and tissues in the absence of the complex system in a whole organism (Rosenoer, 1966). Cultured mammalian cells have been used to study metabolism of pesticides.…”