Tissue adhesives and hemostasis‐inducing compounds: The alkyl cyanoacrylates

Leonard, Fred; Kulkarni, R. K.; Nelson, Joshua; Brandes, George R.

doi:10.1002/jbm.820010103

Cited by 41 publications

(18 citation statements)

References 3 publications

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“…Cyanoacrylate adhesives degrade into formaldehyde and cyanoacetate, which may cause tissue irritation . Shorter chain cyanoacrylate adhesives such as the Loctite® positive control used here are known to be more toxic than longer alkyl chain adhesives such as OCA …”

Section: Discussionsupporting

confidence: 87%

“…There are numerous studies dedicated to analyses of toxicity of cyanoacrylate adhesives for clinical applications, albeit not in the context of a SHM. Cyanoacrylate adhesives degrade into formaldehyde and cyanoacetate, which may cause tissue irritation . Shorter chain cyanoacrylate adhesives such as the Loctite® positive control used here are known to be more toxic than longer alkyl chain adhesives such as OCA …”

Section: Discussionmentioning

confidence: 99%

“…31,[54][55][56][57][58] Shorter chain cyanoacrylate adhesives such as the LoctiteV R positive control used here are known to be more toxic than longer alkyl chain adhesives such as OCA. 31,[54][55][56][57][58][59] Proliferation and viability testing of OCA extracts [Figures 5B and 6(D-F)] clearly showed the OCA was toxic to the MG63 cells in culture, and extracts from the LoctiteV R positive control killed virtually all of the cells. Similar to the work of others with various cyanoacrylates, these results showed both time-and dose-dependent effects on cell proliferation and viability.…”

Section: Discussionmentioning

confidence: 99%

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Mechanical and cytotoxicity testing of acrylic bone cement embedded with microencapsulated 2‐octyl cyanoacrylate

2013

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The water-reactive tissue adhesive 2-octyl cyanoacrylate (OCA) was microencapsulated in polyurethane shells and incorporated into Palacos R bone cement. The tensile and compressive properties of the composite material were investigated in accordance with commercial standards, and fracture toughness of the capsule-embedded bone cement was measured using the tapered double-cantilever beam geometry. Viability and proliferation of MG63 human osteosarcoma cells after culture with extracts from Palacos R bone cement, capsule-embedded Palacos R bone cement, and OCA were also analyzed. Incorporating up to 5 wt % capsules had little effect on the compressive and tensile properties of the composite, but greater than 5 wt % capsules reduced these values below commercial standards. Fracture toughness was increased by 13% through the incorporation of 3 wt % capsules and eventually decreased below the toughness of the capsule-free controls at capsule contents of 15 wt % and higher. The effect on cell proliferation and viability in response to extracts prepared from capsule-embedded and commercial bone cements were not significantly different from each other, whereas extracts from OCA were moderately toxic to cells. Overall, the addition of lower wt % of OCA-containing microcapsules to commercial bone cement was found to moderately increase static mechanical properties without increasing the toxicity of the material.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Mechanical and cytotoxicity testing of acrylic bone cement embedded with microencapsulated 2‐octyl cyanoacrylate

2013

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“…In addition, it should be easily sterilizable and ization to an inherently high modulus crust; their low vissimple to apply. [1][2][3] Of the existing adhesives used in the cosity renders them too fluid for controlled application at biomedical industry, generally these criteria cannot be met the surgical site. 3,15,18 Thus, a new absorbable composition by most of them.…”

Section: Introductionmentioning

confidence: 99%

Performance of modified cyanoacrylate composition as tissue adhesives for soft and hard tissues

Linden

Shalaby

1997

J. Biomed. Mater. Res.

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A suspected absorbable cyanoacrylate, methoxypropyl cyanoacrylate (MPC), was investigated as a component of a new modified cyanoacrylate system. Reactive modifiers based on absorbable polymeric oxalates, which act as plasticizers as well as thickening agents, were incorporated into this system. It was found that the MPC with an oxalate modifier resulted in a higher adhesive strength than isobutyl cyanoacrylate (IBC) when used to approximate soft tissue. However, the IBC was superior in hard tissue applications. This coincides with the conclusion that modulus matching of the adhesive and substrate is a key contributor to joint strength.

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“…8 In contrast with the rate of heterogeneous in vitro degradation of IACA are the results of this study in which no appreciable biodegradation of IACA from topically applied or subcutaneously implanted IACA occurred during a 1 or 2 week period, respectively. The difference in the role of degradation of IACA can be explained by either different mechanism of in vitro and in vivo degradation as suggested by Lehman,9 or topically applied and subcutaneously implanted IACA are not analogous to the simulated in vivo conditions in which IACA is in immediate contact with an aqueous environment.…”

Section: Discussionmentioning

confidence: 70%