Tissue-adhesive and highly mechanical double-network hydrogel for cryopreservation and sustained release of anti-cancer drugs

Zeng, Liangdan; He, Jingjing; Cao, Yang; Wang, Jiaxian; Qiao, Ziwen; Jiang, Xiancai; Hou, Linxi; Zhang, Jin

doi:10.1016/j.smaim.2021.07.005

Cited by 17 publications

(9 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 29 ] Hydrogels have also been identified as promising candidates for chemotherapeutic drug delivery as an alternative to conventional methods. [ 30 ] Overall, these findings strongly support the development and application of hydrogels as delivery systems. In fact, the ability of hydrogels to act as release systems is directly related to their ability to integrate at lesion sites, support tissue regeneration, and load and release a wide range of small molecules or biological compounds.…”

Section: Introductionsupporting

confidence: 57%

Sustained Release of Human Adipose Tissue Stem Cell Secretome from Star‐Shaped Poly(ethylene glycol) Glycosaminoglycan Hydrogels Promotes Motor Improvements after Complete Transection in Spinal Cord Injury Rat Model

Silva

Schirmer

Pinho

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Adipose tissue‐derived stem cells (ASCs) have been shown to assist regenerative processes after spinal cord injury (SCI) through their secretome, which promotes several regenerative mechanisms, such as inducing axonal growth, reducing inflammation, promoting cell survival, and vascular remodeling, thus ultimately leading to functional recovery. However, while systemic delivery (e.g., i.v. [intravenous]) may cause off‐target effects in different organs, the local administration has low efficiency due to fast clearance by body fluids. Herein, a delivery system for human ASCs secretome based on a hydrogel formed of star‐shaped poly(ethylene glycol) (starPEG) and the glycosaminoglycan heparin (Hep) that is suitable to continuously release pro‐regenerative signaling mediators such as interleukin (IL)‐4, IL‐6, brain‐derived neurotrophic factor, glial‐cell neurotrophic factor, and beta‐nerve growth factor over 10 days, is reported. The released secretome is shown to induce differentiation of human neural progenitor cells and neurite outgrowth in organotypic spinal cord slices. In a complete transection SCI rat model, the secretome‐loaded hydrogel significantly improves motor function by reducing the percentage of ameboid microglia and systemically elevates levels of anti‐inflammatory cytokines. Delivery of ASC‐derived secretome from starPEG‐Hep hydrogels may therefore offer unprecedented options for regenerative therapy of SCI.

show abstract

Section: Introductionsupporting

confidence: 57%

Sustained Release of Human Adipose Tissue Stem Cell Secretome from Star‐Shaped Poly(ethylene glycol) Glycosaminoglycan Hydrogels Promotes Motor Improvements after Complete Transection in Spinal Cord Injury Rat Model

Silva

Schirmer

Pinho

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…The porous structure and swelling property enabled hydrogels as important drug-sustained released platforms [ 22 ]. Nonetheless, these conventional structures might lose the ability to control the drug-release rate because the low crosslinking density leads to a high percentage of drug leakage before arriving at the disease site [ 23 ]. As for the microgel-in-gel structures, the microgel could be used as the first impounding reservoir of the drugs before they diffused into the network of the bulk gel, thereby providing a more meticulous drug-release-rate control [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

Precise Design of Alginate Hydrogels Crosslinked with Microgels for Diabetic Wound Healing

Yan

Ren

et al. 2022

Biomolecules

View full text Add to dashboard Cite

Alginate hydrogel has received great attention in diabetic wound healing. However, the limited tunability of the ionic crosslinking method prevents the delicate management of physical properties in response to diverse wound conditions. We addressed this issue by using a microgel particle (fabricated by zinc ions and coordinated through the complex of carboxymethyl chitosan and aldehyde hyaluronic acid) as a novel crosslinker. Then the cation was introduced as a second crosslinker to create a double crosslinked network. The method leads to the precise regulation of the hydrogel characters, including the biodegradation rate and the controlled release rate of the drug. As a result, the optimized hydrogels facilitated the live-cell infiltration in vitro and boosted the tissue regeneration of diabetic wounds in vivo. The results indicated that the addition of the microgel as a new crosslinker created flexibility during the construction of the alginate hydrogel, adapting for diverse applications during diabetic-induced wound therapy.

show abstract

“…At low pH, the CS network would dissipate, whereas the multilayer architecture still kept stable, resulting in a barrier diffusion of the target drug from the Agar network. Zeng et al 223 used Alg-Ca 2+ /PAAm hydrogel to achieve cryopreservation and sustained release of lomustine (anti-cancer drugs for glioblastoma). The hydrogel had a pH sensitivity, resulting in the difference in swelling behavior between pH 5 and 7.…”

Section: Drug Deliverymentioning

confidence: 99%

Recent developments of polysaccharide‐based double‐network hydrogels

Zhang

Shi

Zhou

2022

Journal of Polymer Science

View full text Add to dashboard Cite

Polysaccharides possessing distinctive properties, such as biocompatibility, biodegradability, and nontoxicity, are promising matrices for hydrogels. However, the polysaccharides‐based hydrogels have poor mechanical properties, which is a major limitation for their applications. In recent years, researches on double‐network (DN) hydrogels with outstanding mechanical properties have gained increasing attention. Therefore, the main research orientation is to combine the benefits of both materials and broaden their applications in various fields. This paper reviews the recent progress of polysaccharide‐based DN (PDN) hydrogels that show great advantages in mechanical, physiochemical properties, biocompatibility, biodegradability and so on. The preparation, structure, and unique properties of different PDN hydrogels are discussed in detail. Moreover, we summarize the applications of PDN hydrogels in biomedical and energy storage and conversion fields. This research progress is breaking through the limitations of PDN hydrogels and opening a new avenue for their future development.

show abstract

Tissue-adhesive and highly mechanical double-network hydrogel for cryopreservation and sustained release of anti-cancer drugs

Cited by 17 publications

References 50 publications

Sustained Release of Human Adipose Tissue Stem Cell Secretome from Star‐Shaped Poly(ethylene glycol) Glycosaminoglycan Hydrogels Promotes Motor Improvements after Complete Transection in Spinal Cord Injury Rat Model

Sustained Release of Human Adipose Tissue Stem Cell Secretome from Star‐Shaped Poly(ethylene glycol) Glycosaminoglycan Hydrogels Promotes Motor Improvements after Complete Transection in Spinal Cord Injury Rat Model

Precise Design of Alginate Hydrogels Crosslinked with Microgels for Diabetic Wound Healing

Recent developments of polysaccharide‐based double‐network hydrogels

Contact Info

Product

Resources

About