TIPE2 acts as a biomarker for GIST risk category and suppresses the viability and invasiveness of GIST cells

Li, Zequn; Zhang, Wei; Li, Yang; Cao, Shougen; Liu, Shanglong; Liang, Ning; Jiao, Xuelong; Liu, Zimin; Xing, Xiaoming; Li, Yujun; Zhou, Yanbing

doi:10.1186/s13578-018-0261-z

Cited by 4 publications

(4 citation statements)

References 44 publications

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“…TIPE2 has been shown to exert an inhibitory effect on GIST cell proliferation and invasion by targeting Rac1 [22]. A study published in 2019 revealed that SNAI2 and CDH1 are associated with GIST metastasis.…”

Section: Other Relevant Mechanismsmentioning

confidence: 99%

Research Progress on the Mechanism Related to Recurrence and Metastasis of GIST

Liu,

Liu

2024

IJCEMR

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Gastrointestinal stromal tumors (GISTs) represent the most prevalent malignant mesenchymal tumors occurring in the gastrointestinal tract, with approximately 30% of GISTs classified as malignant. Despite the availability of various effective therapeutic regimens for early-stage treatment, approximately 50% of GIST patients experience recurrent metastasis following treatment and the underlying mechanism of this development remains poorly understood. Consequently, there is a pressing need to further investigate the mechanisms influencing GIST recurrence and metastasis. Such investigations hold great potential for improving patient survival rates. In this manuscript, we provide a comprehensive summary of recent research progress and the current understanding of the recurrence and metastasis mechanisms in GIST. We aim to establish a solid theoretical foundation that can better guide clinical therapeutic strategies.

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Section: Other Relevant Mechanismsmentioning

confidence: 99%

Research Progress on the Mechanism Related to Recurrence and Metastasis of GIST

Liu,

Liu

2024

IJCEMR

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“…Overexpression of TIPE2 in tumor cells induced cell apoptosis and significantly inhibited Ras-induced tumorigenesis through binding to Ras-interacting domain of RGL and inhibiting the activation of Ral ( 9 ). In addition, TIPE2 inhibited invasiveness and tumor development via reducing MMP9 expression by targeting Rac1 in hepatocellular carcinoma (HCC) and gastrointestinal stromal tumor ( 11 , 12 ). TIPE2 also inhibited HCC metastasis through suppressing Erk1/2 and NF-κB activation ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

TIPE2 Suppresses Malignancy of Pancreatic Cancer Through Inhibiting TGFβ1 Mediated Signaling Pathway

et al. 2021

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Pancreatic cancer is one of the major reasons of cancer-associated deaths due to poor diagnosis, high metastasis and drug resistance. Therefore, it is important to understand the cellular and molecular mechanisms of pancreatic cancer to identify new targets for the treatment. TIPE2 is an essential regulator of tumor apoptosis, inflammation and immune homeostasis. However, the role of TIPE2 is still not fully understood in pancreatic cancer. In this study, we found the expression of TIPE2 was decreased in pancreatic cancer tissues compare to paracancerous tissues, which was negatively correlated with tumor size in patients. Overexpression of TIPE2 significantly decreased cell proliferation, metastasis and increased apoptotic events in pancreatic cancer cell lines. Moreover, the results obtained from real time PCR and western blot revealed that TIPE2 was also involved in inhibiting MMPs and N-Cadherin expression while increasing Bax expression in pancreatic cancer cells. Similarly, TIPE2 could inhibit tumor growth in vivo, decrease the expression of Ki-67 and N-Cadherin, and increase the expression of Bax by IHC analysis in tumor tissues isolated from tumor-bearing mice. Mechanistic studies exhibited that TIPE2 might suppress pancreatic cancer development through inhibiting PI3K/AKT and Raf/MEK/ERK signaling pathways triggered by TGFβ1. Moreover, the tumor-infiltrating lymphocytes from tumor-bearing mice were analyzed by flow cytometry, and showed that TIPE2 could promote T cell activation to exert an anti-tumor effect possibly through activation of DCs in a TGFβ1 dependent manner. In general, we described the multiple regulatory mechanisms of TIPE2 in pancreatic tumorigenesis and tumor microenvironment, which suggested TIPE2 may act as a potential therapeutic target in pancreatic cancer.

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“…15,16 TIPE is the founding member of the TIPE -family which also includes the TNFAIP8-like 1 (TIPE1), TNFAIP8-like 2 (TIPE2), and TNFAIP8-like 3 (TIPE3) proteins and plays important roles in the development and progression of cancers. [17][18][19][20][21][22][23] Overexpression of TIPE is frequently observed in malignant cells and is strongly linked to excessive proliferation, reduced apoptosis, enhanced invasion and metastasis. 24 Studies have shown that TIPE overexpression was correlated with cancer progression and poor prognosis in patients with non-small cell lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Tumour Necrosis Factor-α-Induced Protein 8 is Associated with Prognosis in Colon Cancer

Zhang

Sun

et al. 2021

CMAR

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Purpose: The present study aimed to examine the association of tumour necrosis factor-αinduced protein 8 (TIPE) expression levels with clinicopathological features and prognosis of patients with colon cancer following surgery. Patients and Methods: The present study included 200 patients with colon cancer who underwent colon resection between June 2011 and October 2012. All follow-ups were censored in July 2020, with a median follow-up time of 62.25 months. Kaplan-Meier survival curve analysis and Cox regression analysis were used to determine predictors for the overall survival rate. Results: High expression of TIPE was associated with lymph node metastasis, higher Dukes' stage and right-sided colon cancer (RCC). An exploratory subgroup analysis found that high expression of TIPE was associated with age ≥65, lymphatic invasion and higher Dukes' stage only in the RCC group (P<0.05), whereas no similar trend was observed in the left-sided colon cancer (LCC) subgroup. Age ≥65, differentiation, lymph node metastasis and TIPE expression levels were independent prognostic factors influencing the survival rate of patients with colon cancer following surgery in multivariate Cox analysis (P<0.05). ROC curve analysis showed that the immunoreactive score of TIPE had good predictive value for five-year survival rates (AUC=0.727) and lymph node metastasis (AUC=0.760) among patients with RCC. Survival analysis revealed that the expression of TIPE had a significant impact on survival, and higher expression levels suggested a worse prognosis. Conclusion:This study demonstrated that TIPE may be a novel biomarker for predicting the survival outcome and lymph node metastasis. TIPE was overexpressed in colon cancer tissue and significantly associated with poor patient survival, especially in patients with RCC.

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TIPE2 acts as a biomarker for GIST risk category and suppresses the viability and invasiveness of GIST cells

Cited by 4 publications

References 44 publications

Research Progress on the Mechanism Related to Recurrence and Metastasis of GIST

Research Progress on the Mechanism Related to Recurrence and Metastasis of GIST

TIPE2 Suppresses Malignancy of Pancreatic Cancer Through Inhibiting TGFβ1 Mediated Signaling Pathway

Overexpression of Tumour Necrosis Factor-α-Induced Protein 8 is Associated with Prognosis in Colon Cancer

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