TIPE1 suppresses osteosarcoma tumor growth by regulating macrophage infiltration

Chen, P.; Zhou, Jin‐Yong; Li, J.; Zhang, Q.; Zuo, Qiang

doi:10.1007/s12094-018-1927-z

Cited by 24 publications

(22 citation statements)

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“…TIPE1 also inhibits breast cancer cell proliferation, both in vivo and in vitro ( 27 ), whereas it serves as an oncogene in the pathogenesis of cervical cancer ( 17 ). Furthermore, TIPE1 overexpression effectively inhibits osteosarcoma tumor growth in vivo , which may contribute to the inhibition of macrophage infiltration in osteosarcoma ( 18 ). In the present study, the tumor suppressor role of TIPE1 in ovarian cancer was confirmed by promoting apoptosis in vitro and in vivo .…”

Section: Discussionmentioning

confidence: 99%

“…Ectopic TIPE1 expression promotes apoptosis and inhibits cell invasion and migration in several types of cancer ( 14 – 16 ); however, in cervical cancer, TIPE1 facilitates cell proliferation and suppresses the susceptibility of cells to cisplatin chemotherapy ( 17 ). Furthermore, ectopic TIPE1 expression significantly impairs osteosarcoma tumor growth in vivo by inhibiting macrophage infiltration ( 18 ). However, the role of TIPE1 in ovarian serous cancer remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

Deng

et al. 2020

Oncol Lett

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Tumor necrosis factor-α-induced protein 8-like 1 (TIPE1) functions as a tumor suppressor in several types of cancer, including lung and breast cancer. The present study aimed to determine the level of expression and the function of TIPE1 in ovarian cancer. TIPE1 expression was determined in tissue microarrays and ovarian cancer cells, and these data were analyzed to assess the association between TIPE1 expression and prognosis in patients with ovarian cancer. The potential antitumor effects of TIPE1 were investigated in vitro and in a xenograft mouse model. Furthermore, the underlying molecular mechanism by which TIPE1 regulates ovarian cancer growth was determined via flow cytometric analysis, western blotting and rescue experiments. The results of the present study indicated that TIPE1 levels were markedly decreased in ovarian cancer tissues, and its level of expression was associated with a favorable prognosis of patients with ovarian cancer. In addition, ectopic TIPE1 expression significantly impaired A2780 and SKOV3 cell proliferation and colony formation in vitro , which was accompanied by efficient inhibition of xenograft tumor growth in mice. Investigations into the underlying molecular mechanism demonstrated that TIPE1 induced ovarian cancer cell apoptosis by promoting caspase protein expression. Inhibition of caspase-dependent apoptosis by z-VAD blocked TIPE1-mediated inhibition of the proliferation and induction of apoptosis in ovarian cancer cells. Collectively, the results of the present study suggest that TIPE1 may be a potential prognostic predictor and therapeutic target for patients with ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

Deng

et al. 2020

Oncol Lett

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“…Tumor-associated macrophages (TAMs) serve as crucial modulators of the complicated interactions between tumors and the immune system 8. Treatment approaches that affect the bioactivity and/or existence of macrophages have been proved to be promising preclinically and are currently being assessed clinically 9,10. Stimulated macrophages are able to phagocytose malignant cells by hindering the interaction between CD47 and signal regulatory protein alpha (SIRPa), which has been con-temporarily applied to cancer treatment in various clinical trials 11–13.…”

Section: Introductionmentioning

confidence: 99%

<p>SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-κB pathway</p>

Zhou¹,

Yang²,

Li³

2019

OTT

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Background Tumor-associated macrophages (TAMs) serve as crucial modulators of the complicated interaction between cancer cells and immune microenvironment. Sirtuin 1 (SIRT1) has an impact on immune reactions in cancer progression. Current knowledge of the role of SIRT1 in the regulation of M1-like macrophages as well as in hepatocellular carcinoma (HCC) is insufficient. Methods SIRT1 expression in HCC tissues was detected using quantitative reverse transcriptase PCR (qRT-PCR) and Western blot. M1 markers were detected by qRT-PCR and flow cytometry assay. Moreover, the influence of SIRT1 on HCC cell apoptosis, migration, and invasion was studied using transwell assay, flow cytometry assay, and TUNEL assays, respectively. Results In this study, it was revealed that SIRT1 was upregulated in patients suffering from HCC; these patients were also shown to have elevated levels of M1-like TAM infiltration. SIRT1 was able to reinforce M1-like macrophage infiltration and inhibit HCC metastasis. Furthermore, SIRT1 enhanced NF-κB stimulation, promoting phosphorylation of p65, IκB, and IκB kinase. It was further demonstrated in our study that SIRT1 had an impact on polarization of M1 through the NF-κB pathway. NF-κB repression downregulated M1 markers in macrophages, which excessively expressed SIRT1 and counteracted the influence of SIRT1 on migration of HCC cells. Conclusion Taken together, these results offer proof that SIRT1 is an essential regulator of the immune reaction that counteracts malignant HCC cell migration as well as growth, indicating that macrophage SIRT1 could serve as an innovative target to treat HCC.

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“…Zhang et al showed that TIPE1 can induce hepatocellular carcinoma cells to undergo apoptosis by negatively regulating Rac1 activation (12). Moreover, very recent studies indicated that TIPE1 suppresses tumor growth, invasion, and migration in osteosarcoma, lung cancer, and gastric carcinoma (13–15). However, our recent research demonstrated that TIPE1 could promote cervical cancer proliferation, and thus preserves it as a poor prognostic factor for patients with cervical cancer (16), indicating that its biological functions for tumorigenesis remain ambiguous.…”

Section: Introductionmentioning

confidence: 99%

TIPE1 Inhibits Breast Cancer Proliferation by Downregulating ERK Phosphorylation and Predicts a Favorable Prognosis

Chen

Liu

et al. 2019

Front. Oncol.

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TIPE1, which acts as a cell death regulator, has emerged as a tumor suppressor in the process of carcinogenesis. However, our recent research demonstrated that it serves as an oncogene in the pathogenesis of cervical cancer, indicating that the role of TIPE1 in carcinogenesis needs to be further evaluated. In this study, we show that TIPE1 is able to inhibit breast cancer cell growth both in vivo and in vitro . Functionally, TIPE1 inhibits cancer cell proliferation preferentially by downregulating ERK phosphorylation. Furthermore, the expression of TIPE1 is decreased in breast cancer tissues compared to matched adjacent tissues, and its expression is positively correlated with patients' lifespan. These data indicate that TIPE1 suppresses breast cancer proliferation by inhibiting the ERK signaling pathway. This study also suggests that TIPE1 could serve as a potential therapeutic target and a diagnostic biomarker for breast cancer.

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TIPE1 suppresses osteosarcoma tumor growth by regulating macrophage infiltration

Abstract: Collectively, our results demonstrate the anti-tumor role of TIPE1 in osteosarcoma and reveal a novel therapy target for osteosarcoma.

Cited by 24 publications

References 24 publications

TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

<p>SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-κB pathway</p>

TIPE1 Inhibits Breast Cancer Proliferation by Downregulating ERK Phosphorylation and Predicts a Favorable Prognosis

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TIPE1 suppresses osteosarcoma tumor growth by regulating macrophage infiltration

Abstract: Collectively, our results demonstrate the anti-tumor role of TIPE1 in osteosarcoma and reveal a novel therapy target for osteosarcoma.

Cited by 24 publications

References 24 publications

TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

<p>SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-&kappa;B pathway</p>

TIPE1 Inhibits Breast Cancer Proliferation by Downregulating ERK Phosphorylation and Predicts a Favorable Prognosis

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<p>SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-κB pathway</p>