TIPE1 Inhibits Breast Cancer Proliferation by Downregulating ERK Phosphorylation and Predicts a Favorable Prognosis

Hu, Wei; Chen, Feng; Liu, Ling-yun; Li, Na; Tian, Feng; Du, Jie; Zhao, Yi; Xiang, Xinxin; Liu, Kui; Zhao, Peiqing

doi:10.3389/fonc.2019.00400

Cited by 17 publications

(14 citation statements)

References 28 publications

(36 reference statements)

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“…Our previous studies found that TIPE1 was downregulated in hepatocellular carcinoma which could induce caspase-mediated apoptosis and inhibit HCC cell growth both in vitro and in vivo [ 6 ]. Similar results were confirmed and presented in lung cancer [ 7 ], gastric cancer [ 8 ], osteosarcoma [ 9 ], breast cancer [ 10 , 11 ], and colorectal cancer [ 12 ]. A recent study reported that TIPE1 was decreased in tissue microarrays and inhibited proliferation through inducing apoptosis in ovarian cancer cells [ 13 ], but whether TIPE1 related to tumor metastasis was not mentioned.…”

Section: Introductionsupporting

confidence: 81%

TIPE1 Suppresses Growth and Metastasis of Ovarian Cancer

Zhang

Chang

Song

et al. 2021

Journal of Oncology

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TIPE1, a newly identified member in TIPE (TNFAIP8) family, plays an important role in tumorigenesis and immune regulation, but its role in ovarian cancer, especially in tumor metastasis, remains unknown. In the current study, we aimed to reveal the protein expression spectrum of TIPE1 in normal human tissues and explored its relationship with metastasis in ovarian cancer. The results of IHC staining showed that TIPE1 protein was not only detected in cytoplasm in most human tissues but also expressed in both cytoplasm and nucleus in squamous epithelium and some epithelial-derived cells with secretory functions, such as esophagus, cervix uteri and ovary, and thyroid gland. Moreover, TIPE1 protein was downregulated in ovarian cancer tissues compared with that in the paracancerous. More importantly, TIPE1 suppressed tumorigenesis and metastasis of ovarian cancer in vitro and in vivo, as evidence shows its ability to suppress growth, colony formation, migration, and epithelial-mesenchymal transition (EMT) of ovarian cancer. Taken together, our results demonstrate the suppressor role of TIPE1 in ovarian cancer metastasis, indicating TIPE1 might be a metastasis predictor and a novel therapeutic target for ovarian cancer.

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Section: Introductionsupporting

confidence: 81%

TIPE1 Suppresses Growth and Metastasis of Ovarian Cancer

Zhang

Chang

Song

et al. 2021

Journal of Oncology

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“…Recently, Ye et al ( 26 ) reported that ectopic TIPE1 expression efficiently impairs stemness in colorectal cancer both in vitro and in vivo . TIPE1 also inhibits breast cancer cell proliferation, both in vivo and in vitro ( 27 ), whereas it serves as an oncogene in the pathogenesis of cervical cancer ( 17 ). Furthermore, TIPE1 overexpression effectively inhibits osteosarcoma tumor growth in vivo , which may contribute to the inhibition of macrophage infiltration in osteosarcoma ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

Deng

et al. 2020

Oncol Lett

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Tumor necrosis factor-α-induced protein 8-like 1 (TIPE1) functions as a tumor suppressor in several types of cancer, including lung and breast cancer. The present study aimed to determine the level of expression and the function of TIPE1 in ovarian cancer. TIPE1 expression was determined in tissue microarrays and ovarian cancer cells, and these data were analyzed to assess the association between TIPE1 expression and prognosis in patients with ovarian cancer. The potential antitumor effects of TIPE1 were investigated in vitro and in a xenograft mouse model. Furthermore, the underlying molecular mechanism by which TIPE1 regulates ovarian cancer growth was determined via flow cytometric analysis, western blotting and rescue experiments. The results of the present study indicated that TIPE1 levels were markedly decreased in ovarian cancer tissues, and its level of expression was associated with a favorable prognosis of patients with ovarian cancer. In addition, ectopic TIPE1 expression significantly impaired A2780 and SKOV3 cell proliferation and colony formation in vitro , which was accompanied by efficient inhibition of xenograft tumor growth in mice. Investigations into the underlying molecular mechanism demonstrated that TIPE1 induced ovarian cancer cell apoptosis by promoting caspase protein expression. Inhibition of caspase-dependent apoptosis by z-VAD blocked TIPE1-mediated inhibition of the proliferation and induction of apoptosis in ovarian cancer cells. Collectively, the results of the present study suggest that TIPE1 may be a potential prognostic predictor and therapeutic target for patients with ovarian cancer.

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“…Previous studies have shown that TIPE1 can inhibit cell growth and induce cell death in several types of cancer. Supporting this, our group also found that TIPE1 inhibits breast cancer proliferation by inhibiting the ERK pathway ( 7 ). However, we recently demonstrated that TIPE1 significantly induces cell proliferation and tumor burden in cervical cancer ( 6 ).…”

Section: Tipe1 Enhances Cervical Cancer Chemoresistance In a Wild-typmentioning

confidence: 70%

TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner

et al. 2021

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Previous studies have revealed that TIPE1 serves as a tumor suppressor gene in several tumor types. However, we demonstrated that TIPE1 can promote cervical cancer proliferation by suppressing p53 activity. Here, we showed that TIPE1 inhibits cervical cancer cell apoptosis both in vivo and in vitro. Mechanistically, we revealed that TIPE1 facilitates chemoresistance in a wild-type p53-dependent manner. The results indicated that TIPE1 is responsible for the transition from chemosensitivity to chemoresistance, and that it can serve as a promising target in cervical cancer chemotherapy.

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TIPE1 Inhibits Breast Cancer Proliferation by Downregulating ERK Phosphorylation and Predicts a Favorable Prognosis

Cited by 17 publications

References 28 publications

TIPE1 Suppresses Growth and Metastasis of Ovarian Cancer

TIPE1 Suppresses Growth and Metastasis of Ovarian Cancer

TIPE1 impairs ovarian tumor growth by promoting caspase-dependent apoptosis

TIPE1 Promotes Cervical Cancer Cell Chemoresistance to Cisplatin in a Wild-Type p53-Dependent Manner

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