TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway

Chen, Huiyu; Ye, Yuhan; Yang, Yan; Zhong, Min; Gu, Lei; Han, Zhaopu; Qiu, Jianxian; Liu, Zhongchen; Qiu, Xingfeng; Zhuang, Guohong

doi:10.1038/s41392-020-00276-7

Cited by 17 publications

(17 citation statements)

References 5 publications

(6 reference statements)

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“…Finally, also the upregulation of MMP-9 gene was associated with the advanced stage of CRC and suggested as a biomarker predictive of poor overall survival [ 41 , 76 ]. Chen et al indicated that the overexpression of MMP-9 gene promoted CRC metastasis through the MKK-3/p38/NF-κB pro-oncogenic pathway.…”

Section: The Function Of Mmps In Colorectal Polyps and Cancermentioning

confidence: 99%

Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer

Pezeshkian

Nobili

Peyravian

et al. 2021

Cancers

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Colorectal cancer (CRC) is the third and second cancer for incidence and mortality worldwide, respectively, and is becoming prevalent in developing countries. Most CRCs derive from polyps, especially adenomatous polyps, which can gradually transform into CRC. The family of Matrix Metalloproteinases (MMPs) plays a critical role in the initiation and progression of CRC. Prominent MMPs, including MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, and MMP-21, have been detected in CRC patients, and the expression of most of them correlates with a poor prognosis. Moreover, many studies have explored the inhibition of MMPs and targeted therapy for CRC, but there is not enough information about the role of MMPs in polyp malignancy. In this review, we discuss the role of MMPs in colorectal cancer and its pathogenesis

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Section: The Function Of Mmps In Colorectal Polyps and Cancermentioning

confidence: 99%

Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer

Pezeshkian

Nobili

Peyravian

et al. 2021

Cancers

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“…MiR-539 is expressed at low levels in CRC, while TIPE is expressed at high levels in CRC [ 14 ]. Therefore, we wanted to determine whether miR-539 regulates the transcription of TIPE.…”

Section: Resultsmentioning

confidence: 99%

“…Interestingly, we found that TIPE is highly expressed in CRC tissues by bioinformatics and qRT-PCR analyses. Based on our previous research, we hypothesized that TIPE, as an important molecule in the development and progression of CRC, could be a target molecule of miR-539 [ 13 , 14 , 33 ]. Then, as expected, we demonstrated that TIPE was a novel target gene of miR-539 in CRC and that miR-539 promotes ferroptosis by binding to TIPE and inhibiting its expression; additionally, TIPE had no effect on apoptosis (Supplementary Fig.…”

Section: Discussionmentioning

confidence: 99%

“…MiRNAs are implicated in gene regulation through imperfect or perfect binding to the 3ʹ-untranslated regions (UTRs) of their target genes, resulting in translation inhibition and/or corresponding transcript degradation [ 12 ]. In our previous studies, we found TIPE can promote CRC angiogenesis, invasion and metastasis [ 13 , 14 ]. Thus, we suspect that miR-539 functions by binding to TIPE.…”

Section: Introductionmentioning

confidence: 99%

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miR-539 activates the SAPK/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPE

et al. 2021

Self Cite

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Colorectal cancer (CRC) is a common tumor that harms human health with a high recurrence rate. It has been reported that the expression of microRNA-539 (miR-539) is low in several types of cancer, including CRC. Tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8/TIPE) is highly expressed in CRC and promotes the proliferation, migration and angiogenesis of CRC. However, the relationship between miR-539 and TIPE and the mechanisms by which they regulate the proliferation of CRC remain to be explored. We aimed to investigate the functions and mechanisms of miR-539 in CRC proliferation. Functionally, miR-539 can bind to and regulate the expression of TIPE, and miR-539 activates SAPK/JNK to downregulate the expression of glutathione peroxidase 4 (GPX4) and promote ferroptosis. Our data reveal the novel role of miR-539 in regulating ferroptosis in CRC via activation of the SAPK/JNK axis, providing new insight into the mechanism of abnormal proliferation in CRC and a novel potential therapeutic target for advanced CRC.

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“…[ 28 ] The overproliferated cancer‐associated fibroblasts (CAFs) [ 29 ] can promote ECM generation as well as induce tumor metastasis through endothelial–mesenchymal transition and elevating expression of the matrix metalloproteinases (MMPs). [ 30 ] Moreover, intratumoral secretion of the proinflammatory cytokine transforming growth factor‐β (TGF‐β) [ 31 ] can increase the aggressiveness of tumor cells.…”

Section: Tumor Microenvironment and Therapeutic Barriersmentioning

confidence: 99%

Endogenous Stimuli‐Activatable Nanomedicine for Immune Theranostics for Cancer

Wang

Jin

Liu

et al. 2021

Adv Funct Materials

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Cancer immunotherapy has witnessed significant advances in the past decade, however challenges associated with immune‐related adverse effects and immunosuppressive tumor microenvironment, have hindered their clinical application. Stimuli‐activatable nanomedicines hold great potential for improving the efficiency of cancer immunotherapy and minimizing the side effects via tumor‐specific accumulation, controllable drug release profile, and combinational therapy by integrating multiple therapeutic regimens. In this review, the recent advances of stimuli‐activatable nanomedicines for cancer immunotherapy are first described, with particular focus on endogenous stimuli including pH, glutathione, reactive oxygen species, and excessive enzymes within the tumor microenvironment. Then, the endogenous stimuli‐activatable nanomedicines that target tumor cells, immune cells, or periphery immune systems for eliciting sustained systemic immune activation and modulating the immunosuppressive tumor microenvironment, are described. Next, the general mechanisms underlying nanomedicine‐based immunotherapy by eliciting anti‐tumor immune responses and overcoming immunologic tolerance are described. Further, the emerging application of bioimaging techniques for monitoring immune response and evaluating therapy performance is described. Finally, the authors’ perspectives are provided for the clinical translation of nanomedicine‐based cancer immunotherapy.

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TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway

Cited by 17 publications

References 5 publications

Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer

Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer

miR-539 activates the SAPK/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPE

Endogenous Stimuli‐Activatable Nanomedicine for Immune Theranostics for Cancer

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