Tiny 2D silicon quantum sheets: a brain photonic nanoagent for orthotopic glioma theranostics

Miao, Zhaohua; Hu, Dehong; Gao, Duyang; Fan, Linxin; Ma, Yan; Ma, Teng; Liu, Xin; Zheng, Hairong; Zha, Zhengbao; Xu, Chunjian

doi:10.1016/j.scib.2020.09.027

Cited by 19 publications

(14 citation statements)

References 49 publications

(79 reference statements)

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“…In this work, first, 2D Si NSs were synthesized via a simple approach coupling chemical delithiation following the previously reported method. [ 35 ] And then, the layered Si NSs were liquid exfoliation by PVP‐capped. Subsequently, the 2D 5‐Fu‐Si NSs were synthesized by a classical physical electrostatic forces adsorption mechanism following the previous studies.…”

Section: Resultsmentioning

confidence: 99%

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Intravital Whole‐Process Monitoring Thermo‐Chemotherapy Via 2D Silicon Nanoplatform: A Macro Guidance and Long‐Term Microscopic Precise Imaging Strategy

et al. 2021

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Tumor angiogenesis is a complex process that is unamenable to intravital whole‐process monitoring, especially on microscopic assessment of tumor microvessel and quantifying microvascular hemodynamics before and after the nanotherapeutics, which hinder the understanding of nanotheranostics outcomes in tumor treatment. Herein, a new photoacoustic (PA) imaging‐optical coherence tomography angiography (OCTA)‐laser speckle (LS) multimodal imaging strategy is first proposed, which is not only able to precisely macro guide the thermo‐chemotherapy of tumor by monitoring blood oxygen saturation (SaO2) and hemoglobin content (HbT), but also capable of long‐term microscopic investigating the microvessel morphology (microvascular density) and hemodynamics changes (relative blood flow) before and after the nanotherapeutics in vivo. Moreover, to realize the tumor thermo‐chemotherapy treatment based on this novel multimodal imaging strategy, a 2D 5‐fluorouracil silicon nanosheets (5‐Fu‐Si NSs) therapeutic agent is designed. Furthermore, 2D high‐resolution tumor microvascular images in different stage display that tendency of the thermo‐chemotherapy effect is closely associated with tumor angiogenesis. Taken together, the investigations establish the fundamental base in theory and technology for further tailoring the novel specific diagnosis and treatment strategy in tumor. More importantly, this technique will be beneficial to evaluate the tumor microvascular response to nanotherapeutics at microscale.

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Section: Resultsmentioning

confidence: 99%

“…The surface charge of Si NSs is negative. [ 35 ] And the surface charge of 5‐Fu is positive. This is further evidence of the presence of electrostatic interaction between the 5‐Fu molecules and Si NSs.…”

Section: Resultsmentioning

confidence: 99%

Intravital Whole‐Process Monitoring Thermo‐Chemotherapy Via 2D Silicon Nanoplatform: A Macro Guidance and Long‐Term Microscopic Precise Imaging Strategy

et al. 2021

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“…S6), which was calculated based on the Beer-Lambert law (A/L = βC, A is the absorption of SnNSs@PEG at the wavelength of 808 nm, C is the concentration of SnNSs@ PEG, and L is the path length) [45,47,55]. Notably, both the obtained PTCE (η) and NIR extinction coefficient (β) of SnNSs@PEG are much higher than other similar nanomaterials such as BP quantum dots (QDs) [61], germanene QDs [47], boron nanosheet [62], antimonene QDs [45], and silicon quantum sheets [63], demonstrating that SnNSs@ PEG have great potential to serve as promising photothermal agents. Afterward, the photothermal stability of SnNSs@ PEG was evaluated and an FDA-approved photothermal agent, ICG, was used as a comparison.…”

Section: Photothermal Performance Of Snnss@pegmentioning

confidence: 99%

Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics

Ouyang

Zhang

et al. 2021

Nano-Micro Lett.

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Stanene (Sn)-based materials have been extensively applied in industrial production and daily life, but their potential biomedical application remains largely unexplored, which is due to the absence of the appropriate and effective methods for fabricating Sn-based biomaterials. Herein, we explored a new approach combining cryogenic exfoliation and liquid-phase exfoliation to successfully manufacture two-dimensional (2D) Sn nanosheets (SnNSs). The obtained SnNSs exhibited a typical sheet-like structure with an average size of ~ 100 nm and a thickness of ~ 5.1 nm. After PEGylation, the resulting PEGylated SnNSs (SnNSs@PEG) exhibited good stability, superior biocompatibility, and excellent photothermal performance, which could serve as robust photothermal agents for multi-modal imaging (fluorescence/photoacoustic/photothermal imaging)-guided photothermal elimination of cancer. Furthermore, we also used first-principles density functional theory calculations to investigate the photothermal mechanism of SnNSs, revealing that the free electrons in upper and lower layers of SnNSs contribute to the conversion of the photo to thermal. This work not only introduces a new approach to fabricate 2D SnNSs but also establishes the SnNSs-based nanomedicines for photonic cancer theranostics. This new type of SnNSs with great potential in the field of nanomedicines may spur a wave of developing Sn-based biological materials to benefit biomedical applications.

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“…Li 13 Si 4 alloy particles were chosen for the initial reaction with alcohol to produce layered Si particles, which were then immersed into liquid nitrogen and exfoliated by sonication for producing uniform and dispersed 2D Si QSs. [ 99 ] Similarly, 2D silicon nanosheets (SiNSs) with 13 nm thickness were fabricated by probe sonication of octahedron silicon (oct‐Si) microcrystals in N ‐methyl‐2‐pyrrolidone for Raman imaging and photothermal ablation of cancer cells. [ 100 ] The selective delamination of pristine silicon crystals resulted in 2D SiNSs with antibacterial bioactivity via membrane destruction of the bacteria.…”

Section: Synthesis and Surface Engineering Of Two‐dimensional Silicene/silicon Nanosheetsmentioning

confidence: 99%

“…[ 84 ] In addition, polyvinyl pyrrolidone (PVP) was coated onto the surface of 2D Si QSs for in vivo treatment of orthotopic glioma. [ 99 ] For Pt‐functionalized 2D silicene composite nanosheets, biocompatible soybean phospholipid (SP) was effective in surface modification of these composite nanosheets for guaranteeing the subsequent biomedical use with high stability in physiological condition. [ 107 ]…”

Section: Synthesis and Surface Engineering Of Two‐dimensional Silicen...mentioning

confidence: 99%

Two‐Dimensional Silicene/Silicon Nanosheets: An Emerging Silicon‐Composed Nanostructure in Biomedicine

Song

et al. 2021

Advanced Materials

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Silicon‐composed nanomedicines are one of the most representative inorganic nanosystems in theranostic biomedicine. The emerging of new family members of silicon‐composed nanosystems substantially contributes to their further clinical translation. 2D silicene/silicon nanosheets have recently been developed as an emerging topology of silicon‐composed nanoparticles, which features unique planar nanostructure with large surface area, abundant surface chemistry, specific physiochemical property, and desirable biological effects. This progress report highlights and discusses the state‐of‐art developments of the elaborate construction of 2D silicene/silicon nanosheets for versatile biomedical applications, including top–down fabrication, multifunctionalization, surface engineering, and their available biomedical applications in tumor theranostics (e.g., bioimaging, photothermal ablation, chemotherapy, chemoreactive nanotherapy, radiotherapy, and synergistic nanotherapy) and antibacteria. Their large surface area originating from 2D nanostructure not only enables efficient loading and delivery of chemotherapeutic drugs, but also guarantees the multifunctionalization. Especially, 2D silicene/silicon nanosheets harness desirable photothermal‐conversion performance for photonic hyperthermia and photoacoustic imaging in the near infrared biowindow, accompanied with the desirable biodegradability and biocompatibility, which is typically not possessed in other silicon‐composed counterparts. The multivariate analysis on the facing challenges and future developments of these 2D silicene/silicon nanosheets have also been conducted and outlooked for further underpinning their clinical translations.

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Tiny 2D silicon quantum sheets: a brain photonic nanoagent for orthotopic glioma theranostics

Cited by 19 publications

References 49 publications

Intravital Whole‐Process Monitoring Thermo‐Chemotherapy Via 2D Silicon Nanoplatform: A Macro Guidance and Long‐Term Microscopic Precise Imaging Strategy

Intravital Whole‐Process Monitoring Thermo‐Chemotherapy Via 2D Silicon Nanoplatform: A Macro Guidance and Long‐Term Microscopic Precise Imaging Strategy

Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics

Two‐Dimensional Silicene/Silicon Nanosheets: An Emerging Silicon‐Composed Nanostructure in Biomedicine

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