Tinospora cordifolia (Willd.) Hook.f. &amp; Thomson polysaccharides: A review on extraction, characterization, and bioactivities

Kumar, Manoj; Hasan, Muzaffar; Sharma, Anshu; Suhag, Rajat; Maheshwari, Chirag; Radha, .; Chandran, Deepak; Sharma, Kanika; Dhumal, Sangram; Senapathy, Marisennayya; Natarajan, Krishnaprabu; Punniyamoorthy, Sheela; Mohankumar, Pran; Dey, Abhijit; Deshmukh, Vishal; Anitha, T.; Balamurugan, V; Pandiselvam, R.; Lorenzo, José M.; Kennedy, John F.

doi:10.1016/j.ijbiomac.2022.12.181

Cited by 10 publications

(5 citation statements)

References 53 publications

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“…Contaminants in crude sea buckthorn polysaccharides typically include pigments, proteins, and small molecule impurities. While different crude sea buckthorn polysaccharides may require targeted measures, the general impurity removal process involves decolorization, deproteinization, and dialysis [43][44] .…”

Section: Purification Methodsmentioning

confidence: 99%

Prospects of sea buckthorn ( Hippophae rhamnoides L.) polysaccharides: preparation, structural characterization, and bioactivities diversity

Shi,

Wu,

Han

et al. 2024

Food Science and Human Wellness

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Sea buckthorn (Hippophae rhamnoides L.) is a natural homologous substance of medicine and food. Polysaccharide, as one of its primary active components, has very superior biological activity and can be used as a dietary supplement for functional foods, with good commercial prospects. Although initial progress has been made in the study of sea buckthorn polysaccharides, related studies have been fragmented and lacked systematic and generalization. This manuscript presents a critical analysis and systematic summary of the extraction and purification methods, structural characterization and physicochemical properties, biological activity and potential mechanisms, and structure-activity relationships of sea buckthorn polysaccharides. Accumulating evidence has indicated that sea buckthorn polysaccharides, which were widely prepared by water extraction and column chromatography purifications, exhibited exhibit superior biological activities in vitro and in vivo, including antioxidant, immunomodulatory, anti-inflammatory, hepatorenal protective, antibacterial, antiviral, and prebiotic activities. After analysis, it was concluded that there is a correlation between the relevant activities of sea buckthorn polysaccharides and that the structure of sea buckthorn polysaccharides has a great influence on their biological activity. We reviewed the challenges and limitations of sea buckthorn polysaccharides, summarized the critical aspects, and provided suggestions for potential breakthroughs in the research and application of sea buckthorn polysaccharide.

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Section: Purification Methodsmentioning

confidence: 99%

Prospects of sea buckthorn ( Hippophae rhamnoides L.) polysaccharides: preparation, structural characterization, and bioactivities diversity

Shi,

Wu,

Han

et al. 2024

Food Science and Human Wellness

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show abstract

“…First, the exploration scope of extraction technology is too narrow and lacks innovation. Therefore, it is necessary to explore new extraction methods for C. speciosa polysaccharides, such as supercritical fluid extraction, subcritical water extraction, ultrasonic-assisted extraction, and enzyme-assisted extraction, which can be considered in the future [90,91]. In addition, in most cases, the first consideration when evaluating a suitable extraction method is the extraction rate, but attention has not been paid to the strength of polysaccharide activity.…”

Section: Conclusion and Prospectmentioning

confidence: 99%

Recent Advances in Polysaccharides from Chaenomeles speciosa (Sweet) Nakai.: Extraction, Purification, Structural Characteristics, Health Benefits, and Applications

Yu,

Hu,

et al. 2024

Molecules

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This article systematically reviews the extraction and purification methods, structural characteristics, structure–activity relationship, and health benefits of C. speciosa polysaccharides, and their potential application in food, medicine, functional products, and feed, in order to provide a useful reference for future research. Chaenomeles speciosa (Sweet) Nakai. has attracted the attention of health consumers and medical researchers as a traditional Chinese medicine with edible, medicinal, and nutritional benefits. According to this study, C. speciosa polysaccharides have significant health benefits, such as anti-diaetic, anti-inflammatory and analgesic, anti-tumor, and immunomodulatory effects. Researchers determined the molecular weight, structural characteristics, and monosaccharide composition and ratio of C. speciosa polysaccharides by water extraction and alcohol precipitation. This study will lay a solid foundation for further optimization of the extraction process of C. speciosa polysaccharides and the development of their products. As an active ingredient with high value, C. speciosa polysaccharides are worthy of further study and full development. C. speciosa polysaccharides should be further explored in the future, to innovate their extraction methods, enrich their types and biological activities, and lay a solid foundation for further research and development of products containing polysaccharides that are beneficial to the human body.

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“…These bioactive constituents have been associated with a range of physiological effects, making Tinospora cordifolia an intriguing candidate for drug discovery and complementary therapeutic interventions. [ 2 3 4 5 ]…”

Section: Introductionmentioning

confidence: 99%

In vitro Biological Properties and in Silico Studies on Tinospora Cordifolia Stem Aqueous Extract

Nithin Krishna,

Krishnamoorthy,

Veeraraghavan

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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Tinospora cordifolia, commonly known as “Giloy” or “Guduchi,” is a medicinal plant with a rich history in traditional medicine systems. The aqueous extract of Tinospora cordifolia stems has garnered attention due to its reported pharmacological activities. This study aimed to investigate the in vitro biological properties of the aqueous extract and complement the findings with in silico studies to gain insights into potential molecular interactions. The Tinospora cordifolia stem aqueous extract was subjected to a battery of in vitro assays to assess its biological properties. Anti-inflammatory activity was evaluated using invitro assay. To complement the in vitro findings, in silico studies involving molecular docking analyses were conducted to predict potential interactions between the extract’s constituents and relevant biomolecular targets. The in vitro evaluation revealed significant anti-inflammatory activity of the Tinospora cordifolia stem aqueous extract, as evidenced by its ability to suppress the production of pro-inflammatory cytokines. In silico studies provided insights into the molecular interactions between the extract’s bioactive constituents and key inflammatory and antioxidant targets, further supporting the observed biological properties. The combined in vitro biological assays and in silico studies offer a comprehensive assessment of the Tinospora cordifolia stem aqueous extract’s potential therapeutic properties. The demonstrated anti-inflammatory activities align with the traditional use of Tinospora cordifolia and suggest its potential in managing inflammatory and oxidative stress-related disorders. The in silico insights provide a molecular understanding of the extract’s mode of action, strengthening the rationale for further investigation and development of natural products derived from Tinospora cordifolia for pharmaceutical and medicinal applications.

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Tinospora cordifolia (Willd.) Hook.f. & Thomson polysaccharides: A review on extraction, characterization, and bioactivities

Cited by 10 publications

References 53 publications

Prospects of sea buckthorn ( Hippophae rhamnoides L.) polysaccharides: preparation, structural characterization, and bioactivities diversity

Prospects of sea buckthorn ( Hippophae rhamnoides L.) polysaccharides: preparation, structural characterization, and bioactivities diversity

Recent Advances in Polysaccharides from Chaenomeles speciosa (Sweet) Nakai.: Extraction, Purification, Structural Characteristics, Health Benefits, and Applications

In vitro Biological Properties and in Silico Studies on Tinospora Cordifolia Stem Aqueous Extract

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