Tinospora cordifolia (Giloy): Phytochemistry, Ethnopharmacology, Clinical Application and Conservation Strategies

Kumar, Pradeep; Kamle, Madhu; Mahato, Dipendra Kumar; Bora, Himashree; Sharma, Bharti; Rasane, Prasad; Bajpai, Vivek K.

doi:10.2174/1389201021666200430114547

Cited by 30 publications

(21 citation statements)

References 72 publications

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“…the activation of β-cells is thirty-ninth, T-cells one hundred and fifth, and NK cells is 331% severally. Throughout this result the result of the extract on the NK cells is high; this might be vital|a crucial|a vital|a very important feature as a result of the NK cells square measure important effectors of innate immune system [39].…”

Section: Tinospora Cordifoliamentioning

confidence: 89%

Ethnopharmacological review of traditional medicinal plants as immunomodulator

Parbat¹,

Malode²,

Shaikh³

et al. 2021

World J. Bio. Pharm. Health Sci.

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Medicinal plants play significant roles in the prevention of human beings from various pathogenic microorganisms and diseases. The immunomodulators are agents used to modulate the immune system and can be obtained from both natural as well as synthetic origin from plants and chemicals. Alteration within the system is often achieved by immunomodulatory agents from a plant source, low molecular weight compounds like alkaloids and other nitrogen-containing compounds, terpenes, phenols, and high molecular weight compounds like lectins, polysaccharides. The Immune system is a part of the body to detect the pathogen by using a specific receptor to produce an immediate response by the activation of immune components cells, cytokines, and chemokines and also release of an inflammatory mediator. This review also discusses various ethnopharmacological information of traditional medicinal plants being used as immunomodulators.

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Section: Tinospora Cordifoliamentioning

confidence: 89%

Ethnopharmacological review of traditional medicinal plants as immunomodulator

Parbat¹,

Malode²,

Shaikh³

et al. 2021

World J. Bio. Pharm. Health Sci.

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“…In Southeast Asia, the stems, leaves, and tubers of Stephania rotunda are used in the Cambodian, Lao, Indian, and Vietnamese folk medicine systems for years to treat a wide range of ailments [ 41 ], including asthma, headache, fever, and diarrhea. Tinospora cordifolia is used in folk and Ayurvedic medicines throughout India [ 42 ]. This plant contains many pharmaceutical compounds such as alkaloids, diterpenoid lactones, glycosides, steroids, sesquiterpenoid, and phenolics, which make it antidiabetic, antipyretic, anti-inflammatory, antioxidant, hepatoprotective, and immuno-modulatory.…”

Section: Discussionmentioning

confidence: 99%

Distribution of Therapeutic Efficacy of Ranunculales Plants Used by Ethnic Minorities on the Phylogenetic Tree of Chinese Species

Hao

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The medicinal properties of plants can be evolutionarily predicted by phylogeny-based methods, which, however, have not been used to explore the regularity of therapeutic effects of Chinese plants utilized by ethnic minorities. This study aims at exploring the distribution law of therapeutic efficacy of Ranunculales plants on the phylogenetic tree of Chinese species. We collected therapeutic efficacy data of 551 ethnomedicinal species belonging to five species-rich families of Ranunculales; these therapeutic data were divided into 15 categories according to the impacted tissues and organs. The phylogenetic tree of angiosperm species was used to analyze the phylogenetic signals of ethnomedicinal plants by calculating the net relatedness index (NRI) and nearest taxon index (NTI) in R language. The NRI results revealed a clustered structure for eight medicinal categories (poisoning/intoxication, circulatory, gastrointestinal, eyesight, oral, pediatric, skin, and urinary disorders) and overdispersion for the remaining seven (neurological, general, hepatobiliary, musculoskeletal, otolaryngologic, reproductive, and respiratory disorders), while the NTI metric identified the clustered structure for all. Statistically, NRI and NTI values were significant in 5 and 11 categories, respectively. It was found that Mahonia eurybracteata has therapeutic effects on all categories. iTOL was used to visualize the distribution of treatment efficacy on species phylogenetic trees. By figuring out the distribution of therapeutic effects of Ranunculales medicinal plants, the importance of phylogenetic methods in finding potential medicinal resources is highlighted; NRI, NTI, and similar indices can be calculated to help find taxonomic groups with medicinal efficacy based on the phylogenetic tree of flora in different geographic regions.

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“…In the present study, T. cordifolia was selected due to fact that this shrub is indigenous to India and its easy availability ( Virginia and Premila, 2006 ). It has found its medicinal use for the management of various diseases in traditional medicine ( Kumar et al, 2020 ). It has also been referred to as Guduchi (protector of diseases) in the most ancient books such as Sushruta Samhita and Charaka Samhita.…”

Section: Discussionmentioning

confidence: 99%

Tinospora cordifolia (Thunb.) Miers (Giloy) inhibits oral cancer cells in a dose-dependent manner by inducing apoptosis and attenuating epithelial-mesenchymal transition

Patil

Ashi

Hosmani

et al. 2021

Saudi Journal of Biological Sciences

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Background Tinospora cordifolia (Thunb.) Miers (Giloy) has been applied successfully as an anti-inflammatory, anti-diabetic, and even as an anti-cancer agent. Yet, to date, the application of Giloy has not been explored concerning oral cancer. Objectives To assess the effect of T cordifolia (Thunb.) Miers (Giloy) extract (TcE) on an oral cancer cell line. Methods AW13516 (oral cancer cell line) cells were treated with the prepared aqueous extract of TcE for 24 h at various concentrations ranging between 5 μg/ml and 100 μg/ml and compared with control (cells without treatment). Thee effect of the extracts on apoptosis was assessed by through Annexin V flow cytometry assay and Luminometry based assessment of Caspase 8, 9 and caspase 3/7 activity. RNA was isolated from treated cells and gene expression of selected metastatic genes (MMP1, MMP10, and CXCL8); epithelial-mesenchymal stem cell genes (TWIST1, SNAIL, ZEB1, Oct4) and stemness related genses (Nanog, Sox2) were analyzed by using a quantitative real-time PCR system. The experiments were performed in triplicates. Results Aqueous extract of TcE was found to induce apoptosis inducer in AW13516 cells in a concentration-dependent manner and was potent even at a low concentration of 5 μg/ml. The apoptosis induction was confirmed with the caspase activity assay. Treatment of the cells with the extract for 24 h exhibited a significant decrease in the expression of EMT genes in a dose-dependent manner without an effect on the metastatic genes. Conclusion Aqueous extract of TcE induces apoptosis-mediated cell death in the oral cancer cell line AW13516 while attenuating its potential for epithelial mesenchymal transition.

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Tinospora cordifolia (Giloy): Phytochemistry, Ethnopharmacology, Clinical Application and Conservation Strategies

Cited by 30 publications

References 72 publications

Ethnopharmacological review of traditional medicinal plants as immunomodulator

Ethnopharmacological review of traditional medicinal plants as immunomodulator

Distribution of Therapeutic Efficacy of Ranunculales Plants Used by Ethnic Minorities on the Phylogenetic Tree of Chinese Species

Tinospora cordifolia (Thunb.) Miers (Giloy) inhibits oral cancer cells in a dose-dependent manner by inducing apoptosis and attenuating epithelial-mesenchymal transition

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