Tinea Versicolor in Steroid-Treated Patients

Boardman, Charles R.; Malkinson, Frederick D.

doi:10.1001/archderm.1962.01590010050007

Cited by 34 publications

(6 citation statements)

References 35 publications

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“…Tinea versicolor infection was observed in 13.3% of our patients compared to 0.5% in the general population. Boardman and Malkinson [15] and Koranda ct al. [2] observed tinea versicolor infection in 9.4 and 18% of patients, respectively.…”

Section: Discussionmentioning

confidence: 96%

Spectrum of Dermatological Lesions in Renal Allograft Recipients in a Tropical Environment

Sharma

Singh

et al. 1994

Dermatology

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A total of 157 renal allograft recipients were followed for over 1–23 months for the development of dermatological lesions. The non-infective lesions related to immunosuppressive drugs included cushingoid features in 133 (84.7%), xerosis in 120 (76.4%), striae in 69 (43.9%), hypertrichosis in 65 (21.6%), facial erythema in 42 (26.7%) and friable skin in 34 (21.4%) patients. Of the infective lesions, cutaneous mycoses were the most frequent (82.6%) and included tinea corporisand cruris in 82 (52.2%), tinea versicolor in 21 (13.3%), candidiasis in 7 (4%), onychomycosis in 4 (2%) and cryptococcosis in 2 (1.2%) patients. Viral infections included those due to herpes zoster in 17 (10.8%), herpes simplex in 5 (3.1%) and viral warts in 13 (8.2%) patients. Cutaneous malignancy was seen in 1 patient only.

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Section: Discussionmentioning

confidence: 96%

Spectrum of Dermatological Lesions in Renal Allograft Recipients in a Tropical Environment

Sharma

Singh

et al. 1994

Dermatology

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“…The condition occurs mainly between adolescence and middle age, when the sebaceous glands are more active (134), although it has also been reported in children (11,93,284,479) and the elderly (109,285). Predisposing factors include a "genetic susceptibility" (77,175), illness or malnutrition (77), increased plasma cortisol level (57,77,237), and high ambient temperature and humidity (127). The incidence in temperate climates is around 1% (134,183), but incidences as high as 40 to 60% have been reported in tropical climates (209).…”

Section: Pityriasis Versicolormentioning

confidence: 99%

Immunology of Diseases Associated withMalasseziaSpecies

2002

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SUMMARY Malassezia species are members of the human cutaneous commensal flora, in addition to causing a wide range of cutaneous and systemic diseases in suitably predisposed individuals. Studies examining cellular and humoral immune responses specific to Malassezia species in patients with Malassezia-associated diseases and healthy controls have generally been unable to define significant differences in their immune response. The use of varied antigenic preparations and strains from different Malassezia classifications may partly be responsible for this, although these problems can now be overcome by using techniques based on recent work defining some important antigens and also a new taxonomy for the genus. The finding that the genus Malassezia is immunomodulatory is important in understanding its ability to cause disease. Stimulation of the reticuloendothelial system and activation of the complement cascade contrasts with its ability to suppress cytokine release and downregulate phagocytic uptake and killing. The lipid-rich layer around the yeast appears to be pivotal in this alteration of phenotype. Defining the nonspecific immune response to Malassezia species and the way in which the organisms modulate it may well be the key to understanding how Malassezia species can exist as both commensals and pathogens.

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“…Since some conjugal cases of tinea versicolor do occur (215), there may be some degree of infectivity of the responsible organism for normal persons. This infection has been reported to be more frequent in steroidtreated patients, those with Cushing's disease, those undergoing immunosuppression for renal transplantation, and persons who are severely malnourished (29,46,77,156). Genetic susceptibility has also been postulated for tinea versicolor in that infections in relatives occur at a higher than expected rate (35,108,215).…”

Section: Tinea Versicolormentioning

confidence: 99%

Cutaneous defenses against dermatophytes and yeasts

1995

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Predispositions to the superficial mycoses include warmth and moisture, natural or iatrogenic immunosuppression, and perhaps some degree of inherited susceptibility. Some of these infections elicit a greater inflammatory response than others, and the noninflammatory ones are generally more chronic. The immune system is involved in the defense against these infections, and cell-mediated immunity appears to be particularly important. The mechanisms involved in generating immunologic reactions in the skin are complex, with epidermal Langerhans cells, other dendritic cells, lymphocytes, microvascular endothelial cells, and the keratinocytes themselves all participating in one way or another. A variety of defects in the immunologic response to the superficial mycoses have been described. In some cases the defect may be preexistent, whereas in others the infection itself may interfere with protective cell-mediated immune responses against the organisms. A number of different mechanisms may underlie these immunologic defects and lead to the development of chronic superficial fungal infection in individual patients. Although the immunologic defects appear to be involved in the chronicity of certain types of cutaneous fungal infections, treatment of these defects remains experimental at the present time.

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Tinea Versicolor in Steroid-Treated Patients

Cited by 34 publications

References 35 publications

Spectrum of Dermatological Lesions in Renal Allograft Recipients in a Tropical Environment

Spectrum of Dermatological Lesions in Renal Allograft Recipients in a Tropical Environment

Immunology of Diseases Associated withMalasseziaSpecies

Cutaneous defenses against dermatophytes and yeasts

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