Timing of nimodipine therapy for the treatment of vocal fold paralysis

Sridharan, Shaum; Rosen, Clark A.; Smith, Libby J.; Young, VyVy N.; Munin, Michael C.

doi:10.1002/lary.24903

Cited by 26 publications

(22 citation statements)

References 26 publications

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“…). 9 articles were included in the final systematic review: Of these 9 studies, 3 examined cochleovestibular nerve function, including 1 study investigating subjective tinnitus and 2 studies examining vertigo severity 3 studies investigated RLN injury as represented by vocal fold paralysis and the remaining 3 articles studied facial nerve injury as represented by facial muscle paralysis . Study characteristics including study design, number of subjects, intervention, comparison, primary outcome measure, follow‐up duration, adverse events, and summary of results were tabulated in Table .…”

Section: Resultsmentioning

confidence: 99%

“…The efficacy of nimodipine on vocal fold motion recovery following RLN injury was assessed in three studies (Table ) . Of the three studies, two were of a case‐controlled design, both of which scored 6 out of 9 asterisks on the Newcastle‐Ottawa Scale, indicating fair quality.…”

Section: Resultsmentioning

confidence: 99%

“…For Rosen et al, institutional historical control data were used as a comparison group, and these data were reported previously in a separate study . The third study was a case series without a comparison group . We were able to find a meta‐analysis on the natural recovery rate of vocal fold motion in patients with poor prognosis of vocal fold motion recovery based on LEMG criteria and used these data as a comparison group for the third study .…”

Section: Resultsmentioning

confidence: 99%

“… The remaining included studies, including Davies et al, Scheller et al, 2012 and Sridharan et al, were case series. …”

Section: Resultsmentioning

confidence: 99%

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Nimodipine improves vocal fold and facial motion recovery after injury: A systematic review and meta‐analysis

2018

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Introduction Nimodipine is a calcium channel blocker that has been used to treat hypertension and vasospasm. Emerging evidence in the literature suggests that it is neuroprotective by reducing cellular apoptosis after neuronal injury and promoting axonal sprouting at the nodes of Ranvier. Objectives To conduct a systematic review of the usage of nimodipine in cranial nerve injury and to perform a meta‐analysis to estimate the efficacy of nimodipine on functional recovery of the injured cranial nerves. Methods Literature search was performed in eight databases using preferred reporting items for systematic reviews and meta analyses (PRISMA) guidelines. Human studies that used nimodipine as a monotherapy for treating cranial nerve injury were included for review. Cranial nerve function recovery was the primary outcome measure. Results 672 records were screened and 58 full texts in English were assessed. Nine studies were included in the final review. 5 of these, including 110 participants who received nimodipine for either recurrent laryngeal nerve or facial nerve injury and 556 controls, were used for meta‐analysis. Nimodipine significantly increased the odds of vocal fold motion recovery (odds ratio [OR] 13.73, 95% confidence interval [CI] 6.21, 30.38, P < .01), and the odds of facial motion recovery (OR 2.78, 95% CI 1.20, 6.44, P = .02). Overall, nimodipine‐treated patients had significantly higher odds of recovering vocal fold or facial motion compared with controls (OR 6.09, 95% CI 3.41, 10.87, P < .01). Conclusion Existing evidence supports the positive effect of nimodipine on vocal fold and facial motion recovery after injury. Future research should focus on randomized clinical trials comparing recovery rates between nimodipine‐ and placebo‐treated groups. Laryngoscope, 129:943–951, 2019

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“… The remaining included studies, including Davies et al, Scheller et al, 2012 and Sridharan et al, were case series. …”

Section: Resultsmentioning

confidence: 99%

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Nimodipine improves vocal fold and facial motion recovery after injury: A systematic review and meta‐analysis

2018

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“…These additional citations are important contributions to the literature regarding this medication and this topic. It may also be useful to note that we have had a follow‐up paper accepted for publication that looks at optimal timing for the administration of nimodipine for acute vocal fold paralysis …”

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Reply: Timing of nimodipine therapy for treatment of vocal fold paralysis

et al. 2014

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Surgical management of the recurrent laryngeal nerve in thyroidectomy: American Head and Neck Society Consensus Statement

et al. 2018

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"I have noticed in operations of this kind, which I have seen performed by others upon the living, and in a number of excisions, which I have myself performed on the dead body, that most of the difficulty in the separation of the tumor has occurred in the region of these ligaments…. This difficulty, I believe, to be a very frequent source of that accident, which so commonly occurs in removal of goiter, I mean division of the recurrent laryngeal nerve." Sir James Berry (1887).

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Timing of nimodipine therapy for the treatment of vocal fold paralysis

Abstract: Nimodipine treatment for acute VFP yielded equal VF motion recovery rates regardless of when the medication was initiated. Time to recovery of motion was not different between groups studied.

Cited by 26 publications

References 26 publications

Nimodipine improves vocal fold and facial motion recovery after injury: A systematic review and meta‐analysis

Nimodipine improves vocal fold and facial motion recovery after injury: A systematic review and meta‐analysis

Reply: Timing of nimodipine therapy for treatment of vocal fold paralysis

Surgical management of the recurrent laryngeal nerve in thyroidectomy: American Head and Neck Society Consensus Statement

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